Ferroptosis at high altitude: Interplay between hypobaric hypoxia and iron balance alteration in cells [0.03%]
高空缺氧致细胞铁死亡：低压缺氧与胞内铁稳态失衡的互作机制
Shikha Patil,Divya Singh
Shikha Patil
Ferroptosis is a regulated, non-apoptotic form of cell death, characterized by iron-dependent lipid peroxidation. It is typically driven by glutathione depletion and failure of antioxidant defenses such as glutathione peroxidase 4 (GPX4). T...
Sodium nitroprusside improves ischemia-induced neovascularization via the HO-1/NOX and AKT/eNOS signaling pathways in chronic kidney disease [0.03%]
钠硝普鲁士蓝改善慢性肾脏病缺血诱导的新生血管形成通过HO-1 / NOX和AKT / eNOS信号通路
Ching Chen,Min-Yu Yang,Feng-Yen Lin et al.
Ching Chen et al.
Aims: In chronic kidney disease (CKD), the incidence of peripheral arterial disease is elevated and is a major source of morbidity and mortality. Accumulated circulating uremic toxins, particularly asymmetric dimethylargi...
Interleukin-35 alleviates pulmonary arterial hypertension by suppressing the VEGFA/VEGFR2 signaling pathway [0.03%]
白细胞介素35通过抑制血管内皮生长因子途径治疗肺动脉高压
Jie Feng,Kai Li,Leilei Han et al.
Jie Feng et al.
Pulmonary arterial hypertension (PAH) is a serious circulatory disorder defined by elevated pulmonary arterial pressure (PAP) with normal pulmonary capillary wedge pressure (PCWP), driven by pathological remodeling of pulmonary arterioles. ...
Polystyrene microplastics exacerbate experimental chronic kidney disease via inflammatory and oxidative pathways involving NF-κB, ERK/p38 MAPK, and sirtuin-1 [0.03%]
聚苯乙烯微塑料通过炎症和氧化途径（涉及NF-κB，ERK / p38 MAPK和沉默信息调节因子-1）加重实验性慢性肾脏病
Sumaya Beegam,Suhail Al-Salam,Nur Elena Zaaba et al.
Sumaya Beegam et al.
Human exposure to microplastics (MPs) occurs primarily through ingestion, as they contaminate food and water sources and have been detected in biological samples, including urine. Polystyrene MPs (PSMPs), typically ranging from 80 nm to 2 ...
Mechanistic insights into PPARγ's role in suppressing collagen-driven platelet activation [0.03%]
PPARγ通过抑制胶原诱导的血小板活化发挥抗血栓作用的机制研究
Su Bin Wang,Eun Bee Oh,Solee Kim et al.
Su Bin Wang et al.
Aims: Platelets, despite being anucleate, express peroxisome proliferator-activated receptor γ (PPARγ), a nuclear receptor implicated in regulating platelet activation. While previous studies suggested that PPARγ ligan...
MEGF8-mediated GDF8 phosphorylation drives TGF-β hyperactivation in osteoarthritis cartilage degeneration: Mechanism and targeted intervention [0.03%]
MEGF8介导的GDF8磷酸化驱动骨关节炎软骨退变中TGF-β过度活化：机制与靶向干预措施
Weiwei Li,Jiameng Jia,Ruimou Xie et al.
Weiwei Li et al.
The progression of osteoarthritis (OA) is considered to be closely associated with abnormally activated transforming growth factor-beta (TGF-β) signaling. However, the underlying specific regulatory mechanisms remain unclear, and targeted ...
Xue-Long Sun
Xue-Long Sun
Sialic acids (Sias) are acidic 9‑carbon monosaccharides. Both free Sias and conjugated Sias (sialylation) exist in the human body and have decisive impacts on human health and disease. Cellular free Sias are made via de novo biosynthesis, ...
Jiali Jin,Jiaxin Wang,Chunhong Cui et al.
Jiali Jin et al.
Aims: Myogenic urinary retention is a common urological disorder characterized by diminished detrusor contractility, reduced muscle mass, and disorganized muscle bundles, yet its molecular mechanisms are poorly defined. T...
The PRMT-mediated arginine methylation: From molecular mechanisms to therapeutic targets in cardiovascular diseases [0.03%]
蛋白精氨酸甲基转移酶介导的精氨酸甲基化：从分子机制到心血管疾病治疗靶点
Jia-Qi Tang,Yang-Kai Wang,Qi Shen et al.
Jia-Qi Tang et al.
Cardiovascular diseases (CVDs) are the preeminent cause of mortality among non-communicable diseases globally, posing a significant threat to human health and placing a considerable socioeconomic burden on patients and healthcare systems. G...
Olubodun Michael Lateef,Sodiq Fakorede,Chanel Harris et al.
Olubodun Michael Lateef et al.
Mitochondrial dysfunction plays a critical role in cardiovascular aging and is a key player in the development of cardiovascular diseases (CVDs) such as hypertension, arteriosclerosis, aneurysms, and heart failure. Aging disrupts mitochondr...