Yumiao Liu,Yan Lei,Ming Li et al.
Yumiao Liu et al.
Background: This study explored the clinical phenotypic characteristics, auxiliary examination findings, and gene mutation features of a patient with an STK4 gene mutation to increase the ability of clinicians to identify...
L Marques Palma,S Schlaweck,C Flores et al.
L Marques Palma et al.
Aims: Since the COVID-19 pandemic, mRNA-based vaccines have gained prominence and opened up new opportunities for vaccine development. Rapid and long-lasting immune responses to antigens are crucial for the success of vac...
CD36/ANXA1/TLR4/NF-κB Axis Orchestrates Lipid Metabolism, Chronic Inflammation, and Insulin Resistance in Obese Children [0.03%]
CD36/ANXA1/TLR4/NF-κB轴在肥胖儿童脂质代谢、慢性炎症和胰岛素抵抗中发挥协调作用
Yiqing Yao,Weiming Yang,Feng Cheng et al.
Yiqing Yao et al.
Background: Childhood obesity is tightly linked to dyslipidemia, chronic low-grade inflammation, and insulin resistance (IR). CD36 has been implicated in metabolic disease, yet its pediatric mechanisms remain unclear. Thi...
Upregulated Macrophage-Inducible C-Type Lectin on Intermediate Monocytes Facilitates T Helper 17 Cell Differentiation in Systemic Lupus Erythematosus [0.03%]
系统性红斑狼疮中单核细胞上诱导型巨噬细胞C型凝集素的上调促进T辅助细胞17分化
Shuping Li,Jinhong Li,Yan Xiao et al.
Shuping Li et al.
Pattern recognition receptors are crucial for autoimmune responses. While C-type lectins play important roles in immune responses, their involvement in systemic lupus erythematosus (SLE) pathogenesis remains less understood. To investigate ...
FNDC1-driven macrophage polarization promotes breast cancer cell invasion [0.03%]
FNDC1驱动的巨噬细胞极化促进乳腺癌细胞侵袭
Bin Lian,Huihui Yang,Qinghong Qin et al.
Bin Lian et al.
Objectives: Fibronectin Type III Domain Containing 1 (FNDC1) has been linked to several cancers, but its role in breast cancer and its impact on the tumor microenvironment, particularly macrophage polarization, are poorly...
RanGAP1 plays a vital role in anti-infective functions of macrophages and sepsis progression [0.03%]
RanGAP1在巨噬细胞抗感染功能及脓毒症进展中的重要作用
Linlin Mao,Genming Liu,Jiahuan Zhang et al.
Linlin Mao et al.
Ran GTPase-activating protein 1 (RanGAP1) is a known regulator of nucleocytoplasmic transport; however, its specific function within innate immunity remains undefined. Here, we show that low RanGAP1 expression correlates with poor survival ...
Frédéric Rieux-Laucat
Frédéric Rieux-Laucat
It was in June 1995, that the first descriptions of FAS mutations in humans were published in Science[1] and then in Cell[2]. The patients presented with a non-malignant and non-infectious lymphoproliferative syndrome (splenomegaly and mult...
Age-dependent variations in circulating Tfh and Tfr cells following SARS-CoV-2 infection [0.03%]
SARS-CoV-2感染后的年龄依赖性循环Tfh和Tfr细胞变化
Andrey G Velichkov,Rumyana I Susurkova,Angelina I Trifonova et al.
Andrey G Velichkov et al.
Studies of the COVID-19 pandemic revealed differences in the clinical course between paediatric and adult patients. In-depth research on whether T follicular cells support these observations is still ongoing. Circulating Tfh and Tfr cells w...
FcγRIIb deficiency inhibits tumor development by attenuating the immunosuppressive phenotype of MDSCs [0.03%]
FcγRIIb缺乏通过减弱MDSCs免疫抑制表型来抑制肿瘤发生
Wenyan Chen,JiaHua Pan,Xiaomin Ning et al.
Wenyan Chen et al.
Regulation of myeloid-derived suppressor cell (MDSC) programming is critical for controlling tumor growth and anti-tumor immune responses. The role of FcγRIIb in MDSC programming was examined. FcγRIIb deficiency was found to promote MDSC ...
Appearing where it matters: Ectopic Germinal centers in the respiratory Tract after influenza infection [0.03%]
出现在重要位置：流感感染后呼吸道中的异位生发中心
Romain Gailleton,Davide Angeletti
Romain Gailleton
Influenza A virus infects the host through the respiratory mucosa, yet most vaccines are designed to elicit immune responses in secondary lymphoid organs that are anatomically distant from the site of infection. While efficient at generatin...