Ines Lorga,Ximena Léon-Lara,Sarina Ravens
Ines Lorga
γδ T cells represent one of the earliest T cell lineages to develop and persist as long-lived cells after birth. During gestation, distinct developmental waves generate γδ T cells with restricted TCR diversity and pre-set effector funct...
Sana Esmaeeli
Sana Esmaeeli
Nipah virus (NiV) is a highly lethal zoonotic pathogen that continues to re-emerge, as highlighted by recent confirmed cases in India. Although available studies suggest that the virus can disrupt innate immune signaling and induce humoral ...
Src-family kinase control of CAR signaling: the paradoxical and multifaceted role of LCK [0.03%]
Src家族激酶对CAR信号转导的调控：LCK的多面性和矛盾作用
Luca Simeoni,Dimitrios Mougiakakos,Stephan Fricke
Luca Simeoni
Lymphocyte-specific protein tyrosine kinase (LCK) is central to early T-cell receptor (TCR) signaling and is tightly regulated by phosphorylation, protein-protein interactions, and spatial organization to control T-cell activation and fate....
Association of computed tomography densitometry with disease progression and spatial heterogeneity in rheumatoid arthritis-associated interstitial lung disease [0.03%]
基于计算机断层扫描密度测定的肺疾病进展及空间异质性与类风湿关节炎的相关性研究
Zhinan Guo,Yu Zhang,Guanheng Li et al.
Zhinan Guo et al.
Objectives: This study aimed to assess the efficacy of quantitative computed tomography (qCT) in distinguishing rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and monitoring its progression. ...
Vitamin D ameliorates NETosis and Th17/Treg imbalance in experimental autoimmune thyroiditis [0.03%]
维生素D改善实验性自身免疫性甲状腺炎中NETosis及Th17/Treg失衡的作用及其机制研究
Hai-Yan Yang,Xi-Zhen Wu,Yu-Ping Liu et al.
Hai-Yan Yang et al.
Background: Neutrophil extracellular traps (NETs) have been implicated in various autoimmune diseases; however, their role in Hashimoto's thyroiditis (HT) remains poorly understood. This study aimed to characterize NETs f...
Graham Anderson
Graham Anderson
αβT-cells are an essential cellular component of the vertebrate immune system. As the sole site of their production, the thymus represents a key orchestrator of the immune system. Despite this importance, intrathymic T-cell development is...
High expression of IRF8 in AChR-specific cells regulates the function of B cells [0.03%]
IRF8在AChR特异性细胞中的高表达调控B细胞功能
Wei Zhao,Geng Yan,Bo Wei et al.
Wei Zhao et al.
Myasthenia gravis (MG) is a kind of autoimmune disease. Interferon regulatory factor 8 (IRF8) is an interferon common sequence-binding protein. IRF8 is a key factor involved in the development, maturation, and antimicrobial activity of myel...
Immunometabolites and cancer: the role of 2-hydroxyglutarate, succinate, fumarate and itaconate in tumour development and anti-tumour immunity [0.03%]
免疫代谢产物和癌症：2-羟基谷氨酸、琥珀酸、延胡索酸和衣康酸在肿瘤发生和抗肿瘤免疫中的作用
Thomas Pfefer,Anna Hanga Bessenyei,Luke A O&#x;Neill
Thomas Pfefer
The field of immunometabolism has expanded substantially in recent years, with specific metabolic change becoming a key feature that defines the phenotype of immune cells. In cancer however, metabolic change has been investigated for much l...
Evaluation of the diagnostic and prognostic role of TSPAN32 in B-cell acute lymphoblastic leukemia [0.03%]
TSPAN32在B细胞急性淋巴细胞白血病中的诊断和预后作用评估
Grazia Scuderi,Loredana Cocomero,Eugenio Cavalli et al.
Grazia Scuderi et al.
B-cell acute lymphoblastic leukemia (B-ALL) is an aggressive hematologic malignancy characterized by the uncontrolled proliferation of immature B-cell precursors. Despite therapeutic advances, outcomes remain poor in adults and relapsed pat...
PD-L1 expression in cervical cancer tissue is strongly associated with the expression of CD73/TGF-β1, the percentage of CD8+/PD-1+ T cells and disease progression [0.03%]
宫颈癌组织中PD-L1表达与CD73/TGF-β1表达、CD8+/PD-1+T细胞比例及病情进展密切相关
Muñóz-Godínez Ricardo,Monroy-García Alberto,Hernández-Cueto Ángeles María et al.
Muñóz-Godínez Ricardo et al.
The PD-1/PD-L1 signaling pathway plays a pivotal role in dampening anti-tumor immune responses. We previously reported that adenosine (Ado) increases the expression of programmed death ligand 1 (PD-L1) in cervical cancer (CC) cells by induc...