Macrophages promote tumor growth by phagocytosis-mediated cytokine amplification in Drosophila [0.03%]
果蝇巨噬细胞通过介导细胞因子扩增促进肿瘤生长
Eri Hirooka,Ryo Hattori,Keisuke Ikawa et al.
Eri Hirooka et al.
Macrophages in the tumor microenvironment have been suggested to play a key role in driving tumor progression, but the underlying mechanism remains unclear. Here, we show in Drosophila imaginal discs that the phagocytic activity of mature p...
Photoreceptor degeneration induces homeostatic rewiring of rod bipolar cells [0.03%]
光感受器退行性变诱导rod双极细胞稳态重接
Paul J Bonezzi,Rikard Frederiksen,Annabelle N Tran et al.
Paul J Bonezzi et al.
Retinitis pigmentosa (RP) is a constellation of genetically inherited diseases, most often caused initially by mutation of a rod photoreceptor gene and leading eventually to blindness.1 Although the ultimate prognosis for RP is grim, many f...
Mechanical cues polarize ADIP protein complexes to control vertebrate morphogenesis and wound healing [0.03%]
机械线索极化ADIP蛋白复合物以控制脊椎动物形态建成和伤口愈合
Chih-Wen Chu,Satheeja Santhi Velayudhan,Jakob H Schauser et al.
Chih-Wen Chu et al.
Planar cell polarity (PCP) is a phenomenon of coordinated cell orientation in many epithelia and is required for early morphogenetic events, such as vertebrate gastrulation or neural tube closure, that place embryonic tissues in their prope...
Convergent reduction of olfactory genes and olfactory bulb size in mammalian species at altitude [0.03%]
哺乳动物种群在高原上嗅觉基因的汇聚收缩及嗅球体积减小现象
Allie M Graham,Elysia Saputra,Bogdan Kirilenko et al.
Allie M Graham et al.
The invasion of specialized ecological niches can cause drastic changes to selection regimes, resulting in genomic and phenotypic transformation.1 High-altitude habitats offer an excellent opportunity to investigate the genetic basis of loc...
A receptor-inactivation model for single-celled habituation in Stentor coeruleus [0.03%]
隐基藻单细胞习惯化受体失活模型
Deepa H Rajan,Wallace F Marshall
Deepa H Rajan
The single-celled ciliate Stentor coeruleus demonstrates habituation to mechanical stimuli, but the mechanism of learning in this single cell, which lacks a nervous system, is currently not known. Here, we propose a simple biochemistry-base...
Joseph Parker,Matt Pennell
Joseph Parker
A major challenge in biology is comprehending how complex multicellular novelties evolve. Central to this problem is explaining how qualitatively new phenotypic traits - typically the focus of comparative developmental and macroevolutionary...
Ecology: Genomic erosion of mountain grassland plants in greener pastures [0.03%]
生态学：山区草本植物在更茂密的牧场中的基因侵蚀
Maria Dance
Maria Dance
Mountain grasslands are home to important plant species but are threatened by land-use and climate change. A new study integrates satellite and genomic data, revealing how increased vegetation productivity threatens diversity in a grassland...
Victoria Louis,Patrick Emery
Victoria Louis
How marine species cope with both diurnal and tidal cycles is unclear. A new study in crustaceans identifies distinct brain cells that exhibit either 24- or 12.4-hour rhythms of gene expression, thus providing a mechanism for tracking multi...
Tara A Janes,Richard Kinkead
Tara A Janes
Homeostatic control of neural networks is based on monitoring the activity level of neurons and adjusting excitability. A recent study demonstrates that the physical environment per se (temperature) can directly regulate the neural circuits...
Dorothy Munkenbeck Fragaszy,Patricia Izar
Dorothy Munkenbeck Fragaszy
Apparently for their own enjoyment, young white-faced capuchin monkeys abducted dependent infant howler monkeys and kept them for days. This new tradition is the first identified in primates incorporating forcible abduction of another speci...