Cold-gated potentiation of mechanotransduction supports touch sensation below 5°C in a mammalian hibernator [0.03%]
低温门控的机械转导增强作用支持冬眠哺乳动物在5℃以下温度下的触觉感应
Rebecca A Greenberg,Elena O Gracheva,Sviatoslav N Bagriantsev
Rebecca A Greenberg
Peripheral sensory signaling in homeothermic mammals is a thermally constrained process where prolonged exposure to temperatures below 10°C disrupts neurotransmission and may incur irreversible nerve damage. The hibernating thirteen-lined ...
Pranav Misra,Yen-Cheng Shih,Hsiang-Yu Yu et al.
Pranav Misra et al.
Elucidating the internal representation of language in the brain has major implications for cognitive science, brain disorders, and artificial intelligence. A pillar of linguistic studies is the notion that words have defined functions, oft...
Global effectiveness of mountain protected areas for biodiversity conservation across elevational gradient [0.03%]
跨越海拔梯度全球山地保护区生物多样性保护的有效性分析
Tao Hu,Dongmei Xu,Xiaoyu Li et al.
Tao Hu et al.
Mountain regions support rich biodiversity,1 yet they are increasingly threatened by climate change and human activities.2,3 Although protected areas (PAs) are important for mountain biodiversity conservation,4,5 their effectiveness has bee...
Large carnivores shape road safety through effects on prey space use [0.03%]
大型食肉动物通过影响猎物的活动范围来影响道路安全
Justin P Suraci,L Mae Lacey,Arielle W Parsons et al.
Justin P Suraci et al.
Quantifying the ecosystem services provided by large carnivores through their top-down effects on prey1,2,3 is an important strategy for promoting human-carnivore coexistence.4,5,6,7 Such "predation services" may include reductions in wildl...
Philipp Kanis,Miriam Berreiter,Daniel Sieme et al.
Philipp Kanis et al.
Neanderthals had a robust build and distinctive skeletal features. The hypothalamic-pituitary-somatotropic (HPS) axis, with growth hormone (GH) as a central signaling molecule, plays a crucial role in regulating skeletal development. To exp...
Mimics of the chordate gut-brain hormone neurotensin in parasitic intestinal hookworms [0.03%]
肠道寄生钩虫中的神经紧张素同源分子模拟物
Thomas Lund Koch,Ho Yan Yeung,Iris Bea L Ramiro et al.
Thomas Lund Koch et al.
Hookworms of the family Ancylostomatidae are intestinal parasites that infect hundreds of millions of people worldwide, contributing to malnutrition, anemia, and impaired development. Although hookworms are known to secrete immunomodulatory...
Transmission heterogeneity emerges from uncoupled parasite shedding and spreading [0.03%]
解耦的寄生虫脱落和传播导致传输异质性
Luís M Silva,Dominik Vinopal,Victoria G Choi et al.
Luís M Silva et al.
Disease transmission is highly heterogeneous, yet hosts are often classified as high- or low-risk transmitters based on single metrics such as parasite load or shedding. Here, we test whether transmission-associated processes, which are com...
Concerted evolution reveals co-adapted amino acid substitutions in Na+K+-ATPase of frogs that prey on toxic toads [0.03%]
协同进化揭示了青蛙中捕食有毒蟾蜍的适应性氨基酸替代现象（以Na+K+-ATP酶为例）
Shabnam Mohammadi,Lu Yang,Arbel Harpak et al.
Shabnam Mohammadi et al.
Published Erratum
Current biology : CB. 2026 Aug 4:S0960-9822(26)00953-X. DOI:10.1016/j.cub.2026.07.054 2026
Bicaudal D acts as a sensor to enable dynein-kinesin co-dependence [0.03%]
双尾D充当传感器以实现动力蛋白-驱动蛋白相互依赖性的作用
Hailong Lu,M Yusuf Ali,Jill E Macfarlane et al.
Hailong Lu et al.
Cellular cargoes bind both the minus-end-directed motor dynein and the plus-end-directed motor kinesin, enabling bidirectional motion along microtubules. The molecular mechanism to explain why knocking down one motor abolishes motion in bot...
The E3 ubiquitin ligase LOP1 targets PIF4 to control plant morphogenesis [0.03%]
E3泛素连接酶LOP1通过靶向PIF4控制植物形态建成
Zhaoqing Song,Fengyue Zhao,Yeting Bian et al.
Zhaoqing Song et al.
Light signals orchestrate plant morphogenic development, yet the mechanisms linking photoreceptor signaling to growth regulation remain incompletely understood. Here, we report that the RING-finger E3 ubiquitin ligase long petiole 1 (LOP1) ...