Mixed carbon substrates: a necessary nuisance or a missed opportunity? [0.03%]
混合碳质底物：一种难以避免的干扰因素还是一个被忽视的机会？
Nian Liu,Suvi Santala,Gregory Stephanopoulos
Nian Liu
Although fermentation with single carbon sources is the preferred mode of operation in current industrial biotechnology, the use of multiple substrates has been continuously investigated throughout the years. Generally, microbial metabolism...
Engineering cyanobacteria chassis cells toward more efficient photosynthesis [0.03%]
工程改造蓝藻细胞底盘技术以实现更高效的光合作用
Guodong Luan,Shanshan Zhang,Xuefeng Lu
Guodong Luan
Cyanobacteria photosynthetic biomanufacturing provides a promising technology route for green development, but an efficient photosynthesis system is required for economical competitive performance. Synthetic biology approaches have been ado...
Eveline Peeters,Marjan De Mey
Eveline Peeters
Jasmin E Fischer,Anton Glieder
Jasmin E Fischer
In the past two to five years innovative DNA tools and inventive methodologies accelerated the speed of engineering of Komagataella phaffii (Pichia pastoris) for the efficient expression of intracellular and secreted proteins. Going beyond ...
Editorial overview: Reprogramming biology: from biopolymers to complex systems [0.03%]
综述导读：重塑生物学：从生物聚合物到复杂系统
Giovanni Maglia,Wesley Browne
Giovanni Maglia
Editorial overview: Systems biology approaches in biomedicine and human therapy [0.03%]
综述导读：生物医学和人体治疗中的系统生物学方法
Maria I Klapa,Ioannis P Androulakis
Maria I Klapa
Synthetic methylotrophy: Strategies to assimilate methanol for growth and chemicals production [0.03%]
合成甲醇同化能力：增长和化学品生产的策略
Maciek R Antoniewicz
Maciek R Antoniewicz
Methanol is an attractive and broadly available substrate for large-scale bioproduction of fuels and chemicals. It contains more energy and electrons per carbon than carbohydrates and can be cheaply produced from natural gas. Synthetic meth...
Connor Wiegand,Ipsita Banerjee
Connor Wiegand
Pluripotent stems cells (PSCs) can be expanded indefinitely and differentiated into almost any organ-specific cell type. This has enabled the generation of disease relevant tissues from patients in scalable quantities. iPSC-derived organs a...
Connor Wiegand,Ipsita Banerjee
Connor Wiegand
Pluripotent stems cells (PSCs) can be expanded indefinitely and differentiated into almost any organ-specific cell type. This has enabled the generation of disease relevant tissues from patients in scalable quantities. iPSC-derived organs a...
Short RNA regulators: the past, the present, the future, and implications for precision medicine and health disparities [0.03%]
小RNA调节因子：过去、现在和未来及对精准医疗与健康差异的影响
Isidore Rigoutsos,Eric Londin,Yohei Kirino
Isidore Rigoutsos
We herein provide a brief review of the trajectory that the field of short RNA research followed in the last 25 years. We place emphasis on the unexpected discoveries and the ramifications of these discoveries for the field, as well as offe...