In Young Hwang,Matthew Wook Chang
In Young Hwang
There has been a growing emphasis on understanding the important relationship between human-associated microbial communities and disease development. With technological advancements, we are able to gain further insights into host-microbiome...
Sven Panke,Thomas Ward
Sven Panke
Designing a bioremediator: mechanistic models guide cellular and molecular specialization [0.03%]
设计生物修复剂：机制模型引导细胞和分子的专门化
Marco Zaccaria,William Dawson,Viviana Cristiglio et al.
Marco Zaccaria et al.
Bioremediators are cells or non-living subcellular entities of biological origin employed to degrade target pollutants. Rational, mechanistic design can substantially improve the performance of bioremediators for applications, including was...
Multi-chassis engineering for heterologous production of microbial natural products [0.03%]
多底盘策略促进微生物次生代谢产物的异源合成
Jing Ke,Yasuo Yoshikuni
Jing Ke
Microbial genomes encode numerous biosynthetic gene clusters (BGCs) that may produce natural products with diverse applications in medicine, agriculture, the environment, and materials science. With the advent of genome sequencing and bioin...
Biological insights into non-model microbial hosts through stable-isotope metabolic flux analysis [0.03%]
基于稳定同位素代谢流分析了解非经典模式微生物宿主的生物学特性
Xiaoqun Nie,Qiang Hua,Ping Xu et al.
Xiaoqun Nie et al.
Stable-isotope metabolic flux analysis is an important approach to unravel the metabolic network and its regulation in organisms. It has become a key analytical technology for biotechnological applications. During recent years non-model mic...
Elvira Sgobba,Volker F Wendisch
Elvira Sgobba
Microbial consortia were designed for the production of small molecules with 'labor' being divided between two or more microorganisms. Examples of linear designs are substrate conversion preceding target molecule production or subdivision o...
Systematic mapping of protein-metabolite interactions with mass spectrometry-based techniques [0.03%]
基于质谱技术的系统性蛋白质-代谢物相互作用映射方法
Shanshan Li,Wenqing Shui
Shanshan Li
The recent rapid advance of systematic mapping of protein-metabolite interactions (PMIs) in both prokaryotic and eukaryotic cells has been catalyzed by development of innovative and effective proteomics or metabolomics strategies all based ...
Recent advances in modular co-culture engineering for synthesis of natural products [0.03%]
模块化共培养在天然产物合成工程领域的最新进展
Rufeng Wang,Shujuan Zhao,Zhengtao Wang et al.
Rufeng Wang et al.
The microbial production of natural products has been traditionally accomplished in a single organism engineered to accommodate target biosynthetic pathways. Often times, such approaches result in large metabolic burdens as key cofactors, p...
Multi-faceted approaches to discovering and predicting microbial nutritional interactions [0.03%]
探索和预测微生物营养互作的多方位手段
Sebastian Gude,Michiko E Taga
Sebastian Gude
Nearly all microbes rely on other species in their environment to provide nutrients they are unable to produce. Nutritional interactions include not only the exchange of carbon and nitrogen compounds, but also amino acids and cofactors. Int...
Antonin Prévoteau,Jose M Carvajal-Arroyo,Ramon Ganigué et al.
Antonin Prévoteau et al.
Microbial electrosynthesis (MES) is an electrochemical process used to drive microbial metabolism for bio-production, such as the reduction of CO2 into industrially relevant organic products as an alternative to current fossil-fuel-derived ...