Sarah E Bloch,Min-Hyung Ryu,Bilge Ozaydin et al.
Sarah E Bloch et al.
While synthetic nitrogen fuels modern agriculture, its production is energy-intensive, and its application leads to aquatic pollution and greenhouse gas emissions. Sustainable intensification of agriculture to provide both food for humans a...
Tsepo L Tsekoa,Advaita Acarya Singh,Sindisiwe G Buthelezi
Tsepo L Tsekoa
Local manufacturing of protein-based vaccines and therapies in Africa is limited and contributes to a trade deficit, security of supply concerns and poor access to biopharmaceuticals by the poor. Plant molecular farming is a potential techn...
Matthew Dent,Nobuyuki Matoba
Matthew Dent
Plants are routinely utilized as efficient production platforms for the development of anti-cancer biologics leading to novel anti-cancer vaccines, immunotherapies, and drug-delivery modalities. Various biosimilar/biobetter antibodies and i...
Innate immune responses triggered by nucleic acids inspire the design of immunomodulatory nucleic acid nanoparticles (NANPs) [0.03%]
由核酸诱发的固有免疫反应启发了免疫调控核酸纳米颗粒(NANP)的设计
Morgan Chandler,Morgan Brittany Johnson,Martin Panigaj et al.
Morgan Chandler et al.
The unknown immune stimulation by nucleic acid nanoparticles (NANPs) has become one of the major impediments to a broad spectrum of clinical developments of this novel technology. Having evolved to defend against bacterial and viral nucleic...
Microdroplet screening and selection for improved microbial production of extracellular compounds [0.03%]
用于改善微生物细胞外化合物生成的微滴分选和筛选技术
Rinke J van Tatenhove-Pel,Jhonatan A Hernandez-Valdes,Bas Teusink et al.
Rinke J van Tatenhove-Pel et al.
Microorganisms produce extracellular compounds that affect the final product quality in fermentation processes. Selection of overproducing mutants requires coupling of the extracellular product to the producer genotype, which can be achieve...
Sensing the unreachable: challenges and opportunities in biofilm detection [0.03%]
难以触及的生物被膜检测技术：挑战与机遇
Yikang Xu,Yousr Dhaouadi,Paul Stoodley et al.
Yikang Xu et al.
Bacteria can attach to essentially all materials and form multicellular biofilms with high-level tolerance to antimicrobials. Detrimental biofilms are responsible for a variety of problems ranging from food and water contamination, bio-corr...
Peter DeMartino,Darrell W Cockburn
Peter DeMartino
Resistant starch has received a lot of attention for its potential to exert a healthy impact on the gut and certain members of its resident microbiota, particularly through enhanced butyrate production. However, resistant starch is a broad ...
Proteases of Nicotiana benthamiana: an emerging battle for molecular farming [0.03%]
尼古丁酸 Benthamiana 的蛋白酶：分子农场的新兴之战
Philippe V Jutras,Isobel Dodds,Renier Al van der Hoorn
Philippe V Jutras
Molecular farming increasingly uses the tobacco relative Nicotiana benthamiana for production of recombinant proteins through transient expression. Several proteins are produced efficiently with this expression platform, but yields for othe...
Elena Eremeeva,Piet Herdewijn
Elena Eremeeva
To increase the scope of natural biosystem, nucleic acids have been intensively modified. One direction includes the development of a synthetic alternative to the native DNA and RNA, denoted Xenobiotic nucleic acids (XNAs) that are able to ...
Sheeba Murad,Sebastian Fuller,Jonathan Menary et al.
Sheeba Murad et al.
Interest in applications and benefits that Molecular Pharming might offer to Low and Middle Income Countries has always been a potent driver for the research discipline, and a major reason why many scientists entered the field. Although ent...