Christoph Rader
Christoph Rader
Among antibody-based cancer therapies, bispecific antibodies (biAbs) have gained momentum in preclinical and clinical investigations following the regulatory approvals of the trailblazing T-cell engaging biAb (T-biAb) blinatumomab. Discusse...
Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs [0.03%]
半合成青蒿素之外：植物衍生的抗癌药物的代谢工程
Ines Carqueijeiro,Chloe Langley,Dagny Grzech et al.
Ines Carqueijeiro et al.
The discovery and supply of plant-derived anti-cancer compounds remain challenging given their low bioavailability and structural complexity. Reconstituting the pathways of these compounds in heterologous hosts is a promising solution; howe...
Armand Kurum,Min Gao,Li Tang
Armand Kurum
Recent clinical success of systemic cancer immunotherapy has paved the way for the next-generation therapeutics. Nevertheless, cancer immunotherapies, in particular combination therapies, are associated in some cases with severe side effect...
Innovation in plant-based transient protein expression for infectious disease prevention and preparedness [0.03%]
植物瞬时表达技术的创新在传染病预防和应对中的作用
Frank Sainsbury
Frank Sainsbury
Addressing new challenges in global health and biosecurity requires responsive and accessible platforms for the manufacture of preventative or therapeutic interventions. Transient protein expression in plants has evolved into a technology t...
Recent advances on constraint-based models by integrating machine learning [0.03%]
基于约束的模型集成机器学习的最新进展
Pratip Rana,Carter Berry,Preetam Ghosh et al.
Pratip Rana et al.
Research that meaningfully integrates constraint-based modeling with machine learning is at its infancy but holds much promise. Here, we consider where machine learning has been implemented within the constraint-based modeling reconstructio...
Marc-Sven Roell,Matias D Zurbriggen
Marc-Sven Roell
Global food production needs to be increased by 70% to meet demands by 2050. Current agricultural practices cannot cope with this pace and furthermore are not ecologically sustainable. Innovative solutions are required to increase productiv...
Maike Spöring,Monika Finke,Jörg S Hartig
Maike Spöring
The ability to control gene expression via small molecule effectors is important in basic research as well as in future gene therapy applications. Although transcription factor-based systems are widely used, they are not well suited for cer...
Simplified monomeric VHH-Fc antibodies provide new opportunities for passive immunization [0.03%]
简化的单体VHH-Fc抗体为被动免疫提供了新机遇
Henri De Greve,Vikram Virdi,Shruti Bakshi et al.
Henri De Greve et al.
Simplified monomeric monoclonal antibodies consisting of a single-domain VHH, derived from camelid heavy-chain only antibodies, fused with the Fc domain of either IgG (VHH-IgG) or IgA (VHH-IgA) antibodies, are promising therapeutic proteins...
Microfluidic single-cell analysis in biotechnology: from monitoring towards understanding [0.03%]
微流体单细胞分析在生物技术中的应用：从检测到理解
Christian Dusny,Alexander Grünberger
Christian Dusny
Our understanding of the microbial cell is based on averaged values from bulks. Microfluidic single-cell analysis holds the promise of understanding cellular processes from a single cell perspective. But what is needed to measure single-cel...
Modeling ligand docking to RNA in the design of RNA-based nanostructures [0.03%]
基于RNA的纳米结构设计中的配体对接到RNA模拟方法研究
Wojciech Kajetan Kasprzak,Nour Ali Ahmed,Bruce Allen Shapiro
Wojciech Kajetan Kasprzak
RNA has grown in biological importance as the discovery of its many functional roles in the cellular machinery has revealed the potential for targeting it to disrupt cancer pathways. RNA structure underlies its functionality and suitability...