Yeji Kim,Changdai Gu,Hyun Uk Kim et al.
Yeji Kim et al.
Biological knowledge accumulated over the decades and advances in computational methods have facilitated the implementation of pan-genome analysis that aims at better understanding of genotype-phenotype associations of a specific group of o...
Cross-linking/mass spectrometry to get a closer view on protein interaction networks [0.03%]
交叉连接/质谱技术让研究人员更近距离地观察蛋白质相互作用网络
Claudio Iacobucci,Michael Götze,Andrea Sinz
Claudio Iacobucci
Just recently, chemical cross-linking combined with mass spectrometry (XL-MS) has emerged as valuable tool to study protein interaction networks on the system-wide level. The current challenges in XL-MS are to develop robust workflows enabl...
Biotechnological upcycling of plastic waste and other non-conventional feedstocks in a circular economy [0.03%]
生物技术在循环经济中的塑料废物及其他非常规原料的高值利用
Lars Mathias Blank,Tanja Narancic,Jörg Mampel et al.
Lars Mathias Blank et al.
The envisaged circular economy requires absolute carbon efficiency and in the long run abstinence from fossil feedstocks, and integration of industrial production with end-of-life waste management. Non-conventional feedstocks arising from i...
Theodore W Grunberg,Domitilla Del Vecchio
Theodore W Grunberg
Modularity has been the subject of intense investigation in systems biology for more than two decades. Whether modularity holds in biological networks is a question that has attracted renewed attention in recent years with the advent of syn...
Erkko Ylösmäki,Vincenzo Cerullo
Erkko Ylösmäki
The approval of the first oncolytic virus (OV) for the treatment of metastatic melanoma and the recent discovery that the use of oncolytic viruses may enhance cancer immunotherapies targeted against various immune checkpoint proteins have a...
Environmental drivers of metabolic heterogeneity in clonal microbial populations [0.03%]
环境驱动的克隆微生物种群代谢异质性
Frank Schreiber,Martin Ackermann
Frank Schreiber
Microorganisms perform multiple metabolic functions that shape the global cycling of elements, health and disease of their host organisms, and biotechnological processes. The rates, at which different metabolic activities are performed by i...
Tracing metabolic flux through time and space with isotope labeling experiments [0.03%]
同位素标记实验在时间和空间上追踪代谢通量
Doug K Allen,Jamey D Young
Doug K Allen
Metabolism is dynamic and must function in context-specific ways to adjust to changes in the surrounding cellular and ecological environment. When isotopic tracers are used, metabolite flow (i.e. metabolic flux) can be quantified through bi...
Phil Huss,Srivatsan Raman
Phil Huss
Bacteriophages (or 'phages') can be potent biocontrol agents but their potential has not been fully realized due to inherent limitations of natural phages. By leveraging new tools in synthetic biology, natural phages can be engineered to ov...
Kasey Markel,Michael S Belcher,Patrick M Shih
Kasey Markel
Ideotypes are theoretical archetypes of crops which serve as a practical framework for plant breeders to critically evaluate what traits they should be targeting for specific applications. With advances in plant biotechnology and a growing ...
Downstream of the bioreactor: advancements in recovering fuels and commodity chemicals [0.03%]
生物反应器下游技术在燃料和商品化学品回收方面的进展
Maria C Cuellar,Adrie Jj Straathof
Maria C Cuellar
Downstream processing aims at recovering the target product at the required specifications from the bioreactor effluent. Research and development in this field relies on experimental and mathematical tools at the levels of chemical componen...