Network inference in systems biology: recent developments, challenges, and applications [0.03%]
系统生物学中的网络推理：近期进展、挑战及应用
Michael M Saint-Antoine,Abhyudai Singh
Michael M Saint-Antoine
One of the most interesting, difficult, and potentially useful topics in computational biology is the inference of gene regulatory networks (GRNs) from expression data. Although researchers have been working on this topic for more than a de...
Marion Arnaud,Margaux Duchamp,Sara Bobisse et al.
Marion Arnaud et al.
Among immune correlates of clinical responses, tumor-specific neoantigens took the spotlight as relevant targets for cancer immunotherapy. The implementation of pipelines for personalized cancer therapy remains challenging due to the privac...
Organs-on-a-chip as model systems for multifactorial musculoskeletal diseases [0.03%]
器官芯片作为多因素肌肉骨骼疾病模型系统
Chiara Arrigoni,Silvia Lopa,Christian Candrian et al.
Chiara Arrigoni et al.
Multifactorial diseases affecting musculoskeletal tissues are characterized by the interactions between multiple tissues, such as muscle and nerves in neuromuscular diseases, or multiple cellular components in a tissue, as in the case of bo...
Systems and synthetic biology tools for advanced bioproduction hosts [0.03%]
系统与合成生物学工具在先进生物生产宿主中的应用
Yan Chen,Deepanwita Banerjee,Aindrila Mukhopadhyay et al.
Yan Chen et al.
The genomic revolution ushered in an era of discovery and characterization of enzymes from novel organisms that fueled engineering of microbes to produce commodity and high-value compounds. Over the past decade advances in synthetic biology...
Heiko Rischer,Géza R Szilvay,Kirsi-Marja Oksman-Caldentey
Heiko Rischer
Fundamental changes of agriculture and food production are inevitable. Providing food for an increasing population will be a great challenge that coincides with the pressure to reduce negative environmental impacts of conventional agricultu...
Alex R Lederer,Gioele La Manno
Alex R Lederer
Single-cell transcriptomics enables the measurement of gene expression in complex biological systems at the resolution of individual cells. Multivariate analysis of single-cell data helps describe the variation in expression accompanying ce...
Johnathan A Napier,Olga Sayanova
Johnathan A Napier
The global challenges of ensuring sufficient safe and nutritious food for all are enshrined within the Sustainable Development Goals. As our planet's population continues to grow, and as the impacts of climate change and environmental pollu...
Yeast systems biology in understanding principles of physiology underlying complex human diseases [0.03%]
利用酵母系统生物学理解复杂人类疾病背后的生理原理
Rosemary Yu,Jens Nielsen
Rosemary Yu
Complex human diseases commonly arise from deregulation of cell growth, metabolism, and/or gene expression. Yeast is a eukaryal model organism that is widely used to study these processes. Yeast systems biology benefits from the ability to ...
Biobanks for life sciences and personalized medicine: importance of standardization, biosafety, biosecurity, and data management [0.03%]
生命科学和精准医学生物样本库的标准、生物安全、生物安保及数据管理的重要性
Heimo Müller,Georges Dagher,Martina Loibner et al.
Heimo Müller et al.
Biological samples such as tissues, blood and other body fluids, plants or seeds, prokaryotic and eukaryotic cells or isolated biomolecules as well as associated data are the essential raw material for research and development in medicine, ...
Jose L Garcia-Cordero,Sebastian J Maerkl
Jose L Garcia-Cordero
Although not employed in the clinic as of yet, microfluidic systems are likely to become a key technology for cancer diagnostics and prognosis. Microfluidic devices have been developed for the analysis of various biomarkers including circul...