Are dendritic cells the most appropriate therapeutic vaccine for patients with ovarian cancer? [0.03%]
树突状细胞是卵巢癌患者的最适宜治疗性疫苗吗？
Silvia Martin-Lluesma,Michele Graciotti,Alizée J Grimm et al.
Silvia Martin-Lluesma et al.
New treatments are urgently needed in patients with ovarian cancer (OC), as diagnosis is delayed in many instances, resulting in 85% recurrence of the disease following surgery and standard chemotherapy. OC is considered to be an immunologi...
Pollution to products: recycling of 'above ground' carbon by gas fermentation [0.03%]
气体发酵技术回收"地表碳"污染促产品转型升级
Michael Köpke,Séan D Simpson
Michael Köpke
Engineering probiotics for therapeutic applications: recent examples and translational outlook [0.03%]
工程益生菌的治疗方法：近期实例和转化展望
Nikhil Aggarwal,Amy M Ehrenworth Breedon,Christina M Davis et al.
Nikhil Aggarwal et al.
Engineered probiotics are the next generation of live biotherapeutics that have been genetically modified to target specific diseases. With the advancements in synthetic biology, the engineering of probiotics has become increasingly sophist...
Metabolic flux analysis and fluxomics-driven determination of reaction free energy using multiple isotopes [0.03%]
利用多种同位素进行代谢通量分析及通量组学指导的反应自由能测定
Jimmy Xu,Julia Martien,Cole Gilbertson et al.
Jimmy Xu et al.
Metabolite concentrations, fluxes, and free energies constitute the basis for understanding and controlling metabolism. Mass spectrometry and stable isotopes are integral tools in quantifying these metabolic features. For absolute metabolit...
Aditya Sarnaik,Arren Liu,David Nielsen et al.
Aditya Sarnaik et al.
Microbial systems have been widely studied and exploited through genetic engineering to address industrial needs and societal challenges. However, owing to their complexity, singular approaches often do not yield desired or optimal results,...
Modeling regulatory networks using machine learning for systems metabolic engineering [0.03%]
利用机器学习构建调节网络用于系统代谢工程
Mun Su Kwon,Byung Tae Lee,Sang Yup Lee et al.
Mun Su Kwon et al.
Systems metabolic engineering attempts to engineer a production host's biological network to overproduce valuable chemicals and materials in a sustainable manner. In contrast to genome-scale metabolic models that are well established, regul...
Biosynthesis of terpene compounds using the non-model yeast Yarrowia lipolytica: grand challenges and a few perspectives [0.03%]
利用非传统酵母脂养囊唇酵母生物合成萜类化合物的挑战与展望
Alyssa M Worland,Jeffrey J Czajka,Yanran Li et al.
Alyssa M Worland et al.
Yarrowia lipolytica has emerged as an important non-model host for terpene production. However, three main challenges remain in industrial production using this yeast. First, considerable knowledge gaps exist in metabolic flux across multip...
Layered and multi-input autonomous dynamic control strategies for metabolic engineering [0.03%]
分层和多输入的自主动态控制策略在代谢工程中的应用
Christina V Dinh,Kristala Lj Prather
Christina V Dinh
Metabolic engineering seeks to reprogram cells to efficiently produce value-added chemicals. Traditionally, this is achieved by overexpressing the production pathway and/or knocking out competing endogenous pathways. However, limitations in...
Chiara Damiani,Daniela Gaglio,Elena Sacco et al.
Chiara Damiani et al.
Metabolomics is a rapidly expanding technology that finds increasing application in a variety of fields, form metabolic disorders to cancer, from nutrition and wellness to design and optimization of cell factories. The integration of metabo...
James Swartz
James Swartz
Hydrogen is already a major commodity and process intermediate for fertilizer production, petroleum processing, and chemical synthesis. It also offers unrealized potential for energy storage. While biological production offers an expandable...