Emily A Yasi,Nicholas S Kruyer,Pamela Peralta-Yahya
Emily A Yasi
G protein-coupled receptors (GPCRs) detect compounds on the cell surface and are the starting point of a number of medically relevant signaling cascades. Indeed, over 30% of FDA approved drugs target GPCRs, making them a primary target for ...
Organoid technology and applications in cancer immunotherapy and precision medicine [0.03%]
类器官技术及其在癌症免疫治疗和精准医学中的应用
Krisztian Homicsko
Krisztian Homicsko
Tumors are complex ecosystems of multiple cell types in addition to cancer cells. The response to therapies can be shaped by not only cancer cell vulnerabilities but also by the cells of the tumor microenvironment (TME). For cellular immune...
Ruhi Choudhary,Radhakrishnan Mahadevan
Ruhi Choudhary
Synthetic biology has been instrumental in turning microbes into cell-factories capable of diverse processes. A recent application has been to convert them into living therapeutics with diagnostic and production capabilities. These smart pr...
Challenges and opportunities with CRISPR activation in bacteria for data-driven metabolic engineering [0.03%]
基于数据驱动的代谢工程中利用CRISPR激活细菌面临的挑战和机遇
Jason Fontana,David Sparkman-Yager,Jesse G Zalatan et al.
Jason Fontana et al.
Creating CRISPR gene activation (CRISPRa) technologies in industrially promising bacteria could be transformative for accelerating data-driven metabolic engineering and strain design. CRISPRa has been widely used in eukaryotes, but applicat...
Bacterial metabolic heterogeneity: origins and applications in engineering and infectious disease [0.03%]
细菌代谢异质性：起源及在工程和传染病学中的应用
Trent D Evans,Fuzhong Zhang
Trent D Evans
Bacteria within an isoclonal population display significant heterogeneity in metabolism, even under tightly controlled environmental conditions. Metabolic heterogeneity enables influential functions not possible or measurable at the ensembl...
Engineering microbial cell morphology and membrane homeostasis toward industrial applications [0.03%]
工程微生物细胞形态和膜稳定向工业应用发展
Liang Guo,Zixuan Pang,Cong Gao et al.
Liang Guo et al.
Microbial cell factory performance is significantly affected by the cell morphology and membrane homeostasis. It is important to ensure that cell factories are able to regulate cell morphology and maintain membrane homeostasis. Cell morphol...
Genetically-encoded biosensors for analyzing and controlling cellular process in yeast [0.03%]
遗传编码生物传感器在分析和控制酵母细胞进程方面的应用
Monireh Marsafari,Jingbo Ma,Mattheos Koffas et al.
Monireh Marsafari et al.
Yeast has been a robust platform to manufacture a broad range of biofuels, commodity chemicals, natural products and pharmaceuticals. The membrane-bound organelles in yeast provide us the means to access the specialized metabolism for vario...
Matthew B Amrofell,Austin G Rottinghaus,Tae Seok Moon
Matthew B Amrofell
Microbes have become an increasingly powerful chassis for developing diagnostic and therapeutic technologies. While many of the earlier engineering efforts used microbes that expressed relevant proteins constitutively, more microbes are bei...
Beatrix Suess,Thomas Hermann
Beatrix Suess
Sarah Y Neshat,Stephany Y Tzeng,Jordan J Green
Sarah Y Neshat
A growing number of gene delivery strategies are being employed for immunoengineering in applications ranging from infectious disease prevention to cancer therapy. Viral vectors tend to have high gene transfer capability but may be hampered...