A guide to deciphering microbial interactions and metabolic fluxes in microbiome communities [0.03%]
解读微生物组群落中微生物互作及代谢通量指南
Maciek R Antoniewicz
Maciek R Antoniewicz
Microbiomes occupy nearly all environments on Earth. These communities of interacting microorganisms are highly complex, dynamic biological systems that impact and reshape the molecular composition of their habitats by performing complex bi...
Advances in single cell Raman spectroscopy technologies for biological and environmental applications [0.03%]
单细胞拉曼光谱技术在生物和环境研究中的新进展
Dongqi Wang,Peisheng He,Zijian Wang et al.
Dongqi Wang et al.
The increasing sophistication of single cell Raman spectroscopy (SCRS) via its integrations with other advanced analytical techniques and modern data analytics, enable unprecedented exploration of complex biological and environmental sample...
Recent advances in improving metabolic robustness of microbial cell factories [0.03%]
提高微生物细胞工厂代谢鲁棒性的新进展
Tian Jiang,Chenyi Li,Yuxi Teng et al.
Tian Jiang et al.
Engineering microbial cell factories has been widely applied to produce compounds spanning from intricate natural products to bulk commodities. In each case, host robustness is essential to ensure the reliable and sustainable production of ...
Employment of targeted nanoparticles for imaging of cellular processes in cardiovascular disease [0.03%]
靶向纳米颗粒在心血管疾病细胞过程影像中的应用
Mallika Modak,Molly A Frey,Sijia Yi et al.
Mallika Modak et al.
Cardiovascular disease (CVD) is a leading cause of global mortality, accounting for pathologies that are primarily of atherosclerotic origin and driven by specific cell populations. A need exists for effective, non-invasive methods to asses...
Enzymatic control of product distribution in terpene synthases: insights from multiscale simulations [0.03%]
萜类合成酶中酶促控制产物分布的见解来自多尺度模拟研究
Keren Raz,Shani Levi,Prashant Kumar Gupta et al.
Keren Raz et al.
In this opinion, we review some recent work on terpene biosynthesis using multiscale simulation approaches, with special focus on contributions from our group. Terpene synthases generate terpenes employing rich carbocation chemistry, includ...
Bioengineered pluripotent stem cell models: new approaches to explore early human embryo development [0.03%]
生物工程多能干细胞模型：探索早期人类胚胎发育的新方法
Agnes M Resto Irizarry,Sajedeh Nasr Esfahani,Jianping Fu
Agnes M Resto Irizarry
Human development is a complex process in which environmental signals and factors encoded by the genome interact to engender cell fate changes and self-organization that drive the progressive formation of the human body. Herein, we discuss ...
Christoph Schilling,Abinaya Badri,Volker Sieber et al.
Christoph Schilling et al.
Functional carbohydrate polymers are of immense industrial interest for high value applications. Distinct biosynthetic pathways allow for metabolic engineering approaches for production in microbial cell factories. The most common strategie...
Engineering immunogenic cell death with nanosized drug delivery systems improving cancer immunotherapy [0.03%]
利用纳米药物递送系统工程化免疫原性细胞死亡以改善癌症免疫治疗
Wenlu Yan,Tianqun Lang,Xianrong Qi et al.
Wenlu Yan et al.
Many anti-cancer therapies can induce or enhance the immunogenic cell death (ICD), a process that releases damage-associated molecular patterns (DAMPs) to prime antigen processing and presentation necessary for successful cancer immunothera...
Challenges and advantages of cell therapy manufacturing under Good Manufacturing Practices within the hospital setting [0.03%]
医院细胞治疗生产中的质量控制挑战与优势分析
Emanuela M Iancu,Lana E Kandalaft
Emanuela M Iancu
Academic medicine serves to advance the scientific field and provide the highest quality of clinical care. This applies to cancer where there is a continuous unmet need for innovation. In the last decade, we have observed a significant deve...
Combining protein and metabolic engineering to construct efficient microbial cell factories [0.03%]
结合蛋白质和代谢工程构建高效的微生物细胞工厂
Ning Xu,Yuwan Liu,Huifeng Jiang et al.
Ning Xu et al.
Microbial cell factories offer great opportunities for the feasible biosynthesis of various value-added products from renewable resources. In recent years, protein engineering has served as a powerful approach for generating enzymes or prot...