Yichao Han,Fuzhong Zhang
Yichao Han
When engineering microbes to overproduce a target molecule, engineers face multiple layers of trade-offs to allocate limited cellular resources between the target pathway and native cellular systems. These trade-offs arise from limited free...
Rebecca P Chen,Victoria M Hunt,Alexander A Mitkas et al.
Rebecca P Chen et al.
To maximize desired products in engineered cellular factories it is often necessary to optimize metabolic flux. While a number of works have focused on metabolic pathway enhancement through genetic regulators and synthetic scaffolds, these ...
A roadmap to engineering antiviral natural products synthesis in microbes [0.03%]
在微生物中构建抗病毒天然产物合成之路
Jingbo Ma,Yang Gu,Peng Xu
Jingbo Ma
Natural products continue to be the inspirations for us to discover and acquire new drugs. The seemingly unstoppable viruses have kept records high to threaten human health and well-being. The diversity and complexity of natural products (N...
Zhiyuan Fan,Pu Zhu,Yucheng Zhu et al.
Zhiyuan Fan et al.
One of the grand challenges at the forefront of bionanomaterials is their quick clearance in blood circulation. Progress has been made in understanding nanomaterial-biological system interactions and in developing new strategies to extend t...
Heterologous biosynthesis as a platform for producing new generation natural products [0.03%]
异源生物合成作为生产新一代天然产物的平台
Dongwon Park,Girish Swayambhu,Blaine A Pfeifer
Dongwon Park
Natural products have demonstrated value across numerous application areas, with antibiotics a notable historical example. Native cellular hosts provide an initial option in efforts to harness natural product production. However, various co...
Engineering nanoparticulate vaccines for enhancing antigen cross-presentation [0.03%]
工程纳米颗粒疫苗以提高抗原交叉呈现的能力
Guangsheng Du,Xun Sun
Guangsheng Du
Efficient cross-presentation is pivotal for vaccination against cancer and infection by intracellular virus and bacteria. Recently, various types of nanoparticle vaccines have been developed and investigated for efficiently and specifically...
Chassis engineering for microbial production of chemicals: from natural microbes to synthetic organisms [0.03%]
底盘工程促进微生物化学品生产：从天然菌种到合成生物体
Jingyi Liu,Xia Wu,Mingdong Yao et al.
Jingyi Liu et al.
Chassis provides a setting for the expression of heterologous pathway genes, which often requires extensive engineering to achieve complete functions. Traditionally, chassis engineering relies on gene deletion/overexpression for the regulat...
Mingfeng Cao,Vinh G Tran,Huimin Zhao
Mingfeng Cao
Microorganisms have been increasingly explored as microbial cell factories for production of fuels, chemicals, drugs, and materials. Among the various metabolic engineering strategies, directed genome evolution has emerged as one of the mos...
Linshan Zhu,Yiqian Wu,Chi Woo Yoon et al.
Linshan Zhu et al.
Recent synthetic biology advancements have shown that cells can be engineered to respond to external stimuli such as chemical compounds and light, which significantly improves the specificity and controllability of CAR T therapy. However, t...
Advances in microphysiological blood-brain barrier (BBB) models towards drug delivery [0.03%]
微生理血脑屏障(BBB)模型在药物递送方面的研究进展
Caleb S Lee,Kam W Leong
Caleb S Lee
Though the blood-brain barrier (BBB) is vital for the maintenance of brain homeostasis, it also accounts for a high attrition rate of therapies targeting the central nervous system (CNS). The challenge of delivery across the BBB is attribut...