Transporter engineering in microbial cell factories: the ins, the outs, and the in-betweens [0.03%]
微生物细胞工厂中的运输蛋白工程-输入，输出以及之间的过程
Steven A van der Hoek,Irina Borodina
Steven A van der Hoek
Engineering the transport of small molecules is an effective approach to improve the performance of microbial cell factories. Transporter engineering can improve the utilization of low-cost alternative substrates, reduce the loss of pathway...
Christoph Wittmann,Sang Yup Lee
Christoph Wittmann
Editorial overview: Pharmaceutical biotechnology: new frontiers in cancer immunotherapy [0.03%]
综述：制药生物技术：癌症免疫治疗的新领域
Lana E Kandalaft,Michele Graciotti
Lana E Kandalaft
Kang Zhou,Wenfa Ng,Yoel Cortés-Peña et al.
Kang Zhou et al.
Machine learning is transforming many industries through self-improving models that are fueled by big data and high computing power. The field of metabolic engineering, which uses cellular biochemical network to manufacture useful small mol...
Johanna Chiffelle,Raphael Genolet,Marta As Perez et al.
Johanna Chiffelle et al.
The recent developments of high-throughput bulk and single-cell sequencing technologies accelerated the understanding of the complexity of immune repertoire dynamics combined to transcriptomics. Also, profiling of cellular repertoires in he...
Maria Ochoa de Olza,Jean Bourhis,Melita Irving et al.
Maria Ochoa de Olza et al.
Local administration of ionizing radiation to tumors can promote anticancer immune responses that lead to the abscopal regression of distant metastases, especially in patients receiving systemic immune-checkpoint inhibitors. Growing preclin...
Karolis Petkevicius,Christer Löfstedt,Irina Borodina
Karolis Petkevicius
Metabolic engineering strategies to overcome precursor limitations in isoprenoid biosynthesis [0.03%]
代谢工程策略克服类异戊二烯生物合成中的前体限制问题
Yuexuan Zu,Kristala Lj Prather,Gregory Stephanopoulos
Yuexuan Zu
Isoprenoid biosynthesis has been a focus of metabolic engineering due to the broad spectrum of uses of isoprenoid products and the limited capacity to source them from plants or chemically synthesize them. Microbial synthesis offers the pot...
Editorial overview: Analytical biotechnology in the era of high-performance omics, synthetic biology, and machine learning [0.03%]
综述：高性能组学、合成生物学和机器学习时代的分析生物技术
Yinjie J Tang,Ludmilla Aristilde
Yinjie J Tang
Jin Jin,Bin Jia,Ying-Jin Yuan
Jin Jin
Genome structural variations enable microbes to evolve quickly under environmental stress. Recent efforts in synthetic biology have shown the ability of yeast chromosomal engineering to generate a larger scale of genome structural variation...