Virus-induced metabolic reprogramming and innate sensing hereof by the infected host [0.03%]
病毒诱导的代谢重构及感染机体对其的先天性感知
Jacob Thyrsted,Christian Kanstrup Holm
Jacob Thyrsted
To make new infectious particles, all viruses must manipulate host cell metabolism to secure sufficient availability of biomolecules and energy-a phenomenon now known as metabolic reprogramming. Numerous observations of this has already bee...
Discovery of post-translational modifications in immunometabolism by chemical proteomics [0.03%]
运用化学蛋白质组学发现免疫代谢中的翻译后修饰
Yanling Zhang,Wei Qin,Chu Wang
Yanling Zhang
Metabolic reprogramming of macrophages during immune activation can generate diversified types of small molecule metabolites, which in turn induce post-translational modifications (PTMs) on proteins. Understanding the functional implication...
Conquering CRISPR: how phages overcome bacterial adaptive immunity [0.03%]
征服CRISPR系统：噬菌体如何克服细菌获得性免疫系统
Lucia M Malone,Nils Birkholz,Peter C Fineran
Lucia M Malone
The rise of antibiotic-resistant bacteria has led to renewed interest in the use of their natural enemies, phages, for the prevention and treatment of infections. However, phage therapy requires detailed knowledge of the interactions betwee...
Huan Peng,Irene A Chen
Huan Peng
Phages are versatile agents for delivering a variety of cargo, including nanomaterials, nucleic acids, and small molecules. A potentially important application is treatment of antibiotic-resistant infections. All of these applications requi...
Doris M Jacobs,Marco A van den Berg,Robert D Hall
Doris M Jacobs
Metabolomics is proving a useful approach for many of the main future goals in agronomy and food production such as sustainability/crop resilience, food quality, safety, storage, and nutrition. Targeted and/or untargeted small-molecule anal...
Akarawin Hongdusit,Evan T Liechty,Jerome M Fox
Akarawin Hongdusit
Signaling networks control the flow of information through biological systems and coordinate the chemical processes that constitute cellular life. Optogenetic actuators - genetically encoded proteins that undergo light-induced changes in ac...
Lysins breaking down the walls of Gram-negative bacteria, no longer a no-go [0.03%]
分解革兰氏阴性菌细胞壁的溶菌酶类，曾经的不可能成为可能
Diana Gutiérrez,Yves Briers
Diana Gutiérrez
Phage lysins are one of the most advanced classes of antibacterials under clinical evaluation and have a new mode of action based on peptidoglycan degradation. Lysins were initially excluded from use against Gram-negative pathogens because ...
Florencia Payaslian,Victoria Gradaschi,Mariana Piuri
Florencia Payaslian
The alarming increase in antibiotic resistance has placed the focus on phages as an alternative antimicrobial therapy. Recently, the first patient treatment using engineered phages to combat a mycobacterial infection was successfully perfor...
Computational approaches to understanding nutrient metabolism and metabolic disorders [0.03%]
理解营养代谢和代谢障碍的计算方法
Corrado Priami
Corrado Priami
Computational methods are becoming more and more essential to elucidate biological systems. Many different approaches exist with pros and cons. This paper reviews the most useful technologies focusing on nutrient metabolism and metabolic di...
The potential of remote sensing and artificial intelligence as tools to improve the resilience of agriculture production systems [0.03%]
遥感和人工智能作为提高农业生产能力系统恢复力的工具的潜力
Jinha Jung,Murilo Maeda,Anjin Chang et al.
Jinha Jung et al.
Modern agriculture and food production systems are facing increasing pressures from climate change, land and water availability, and, more recently, a pandemic. These factors are threatening the environmental and economic sustainability of ...