Looking into the future of phage-based control of zoonotic pathogens in food and animal production [0.03%]
探究噬菌体为基础的食源性人畜共患病原菌防控技术的发展方向与应用前景
Michela Gambino,Lone Brøndsted
Michela Gambino
Using bacteriophages (phages) to control zoonotic pathogens in food and animal production is a realistic and promising antimicrobial approach. Recent studies have demonstrated their efficacy and safety, yet bringing phage products on the ma...
Sofia Dahlman,Laura Avellaneda-Franco,Jeremy J Barr
Sofia Dahlman
The concept of (bacterio)phage therapy is simple; target the phage to the bacterial pathogen causing disease. As phages are natural killers of bacteria, one could expect this to be an easy task. However, when it comes to phage therapy withi...
The future of phage biocontrol in integrated plant protection for sustainable crop production [0.03%]
噬菌体生物控制在可持续作物生产的综合植物保护中的未来展望
Dominique Holtappels,Kiandro Fortuna,Rob Lavigne et al.
Dominique Holtappels et al.
Bacterial phytopathogens significantly reduce crop yields and hence, pose a threat to the food supply of our increasing world population. In this context, bacteriophages are investigated as potential sustainable biocontrol agents. Here, rec...
Carbohydrate-Active enZyme (CAZyme) enabled glycoengineering for a sweeter future [0.03%]
基于碳水化合物活性酶（CAZymes）的糖工程学助力更甜的未来
Chandra Kanth Bandi,Ayushi Agrawal,Shishir Ps Chundawat
Chandra Kanth Bandi
One of the stumbling blocks to advance the field of glycobiology has been the difficulty in synthesis of bespoke carbohydrate-based molecules like glycopolymers (e.g. human milk oligosaccharides) and glycoconjugates (e.g. glycosylated monoc...
Jacob A Fenster,Carrie A Eckert
Jacob A Fenster
Functional genomics remains a foundational field for establishing genotype-phenotype relationships that enable strain engineering. High-throughput (HTP) methods accelerate the Design-Build-Test-Learn cycle that currently drives synthetic bi...
Resolving complex phenotypes with Raman spectroscopy and chemometrics [0.03%]
拉曼光谱和化学计量学在解析复杂表型方面的应用
Ryan S Senger,David Scherr
Ryan S Senger
Raman spectroscopy and chemometric analyses are used to characterize phenotypes of biological samples. The approach is relevant in biotechnology to identify and monitor productive cell cultures. It can also detect the presence of pathogens ...
Dylan G Ryan,Christian Frezza,Luke Aj O&#x;Neill
Dylan G Ryan
A major question remaining in the field of evolutionary biology is how prokaryotic organisms made the leap to complex eukaryotic life. The prevailing theory depicts the origin of eukaryotic cell complexity as emerging from the symbiosis bet...
Engineering biology approaches for food and nutrient production by cyanobacteria [0.03%]
工程生物学在蓝藻食品和营养生产中的应用
Deng Liu,Michelle Liberton,John I Hendry et al.
Deng Liu et al.
As photoautotrophic organisms, cyanobacteria capture and store solar energy in the form of biomass. Cyanobacterial biomass has been an important component of diet and nutrition in several regions for centuries. Synthetic biology strategies ...
Bacteriophage endolysins - extending their application to tissues and the bloodstream [0.03%]
噬菌体溶菌酶：将其应用于组织和血液中的应用扩展
Mathias Schmelcher,Martin J Loessner
Mathias Schmelcher
The rapid emergence of antibiotic-resistant bacteria and the lack of novel antibacterial agents pose a serious threat for patients and healthcare systems. Bacteriophage-encoded peptidoglycan hydrolases (endolysins) represent a promising new...
Shomeek Chowdhury,Stephen S Fong
Shomeek Chowdhury
Genome-scale metabolic modeling is a scalable and extensible computational method for analyzing and predicting biological function. With the ongoing improvements in computational methods and experimental capabilities, genome-scale metabolic...