Metabolic traits ruling the specificity of the immune response in different cancer types [0.03%]
决定不同类型癌症免疫反应特异性的代谢特征
Nina C Flerin,Federica Cappellesso,Samantha Pretto et al.
Nina C Flerin et al.
Cancer immunotherapy aims to augment the response of the patient's own immune system against cancer cells. Despite effective for some patients and some cancer types, the therapeutic efficacy of this treatment is limited by the composition o...
Emerging computational tools and models for studying gut microbiota composition and function [0.03%]
新兴计算工具和模型在研究肠道微生物组组成及功能方面的应用
Seo-Young Park,Arinzechukwu Ufondu,Kyongbum Lee et al.
Seo-Young Park et al.
The gut microbiota and its metabolites play critical roles in human health and disease. Advances in high-throughput sequencing, mass spectrometry, and other omics assay platforms have improved our ability to generate large volumes of data e...
Ultrasonographic features of ovarian morphology capture nutritional and metabolic influences on the reproductive axis: implications for biomarker development in ovulatory disorders [0.03%]
卵巢形态的超声影像特征可捕捉营养及代谢对生殖系统的影响：对促排卵障碍生物标志物开发的意义
Heidi Vanden Brink,Jeffrey Pea,Marla E Lujan
Heidi Vanden Brink
Ultrasonographic imaging of ovarian morphology is used widely to inform reproductive health status in women. Metabolic disturbances induced by a negative energy balance (e.g. undernutrition) or positive energy balance (e.g. overnutrition, o...
Engineering xylose metabolism in yeasts to produce biofuels and chemicals [0.03%]
利用酵母代谢木糖生产生物燃料和化学品的技术开发
Jae Won Lee,Sangdo Yook,Hyungi Koh et al.
Jae Won Lee et al.
Xylose is the second most abundant sugar in lignocellulosic biomass. Efficient and rapid xylose utilization is essential for the economic bioconversion of lignocellulosic biomass into value-added products. Building on previous pathway engin...
Fermented food products in the era of globalization: tradition meets biotechnology innovations [0.03%]
全球化时代的发酵食品：传统遇见生物技术革新
Andrea Galimberti,Antonia Bruno,Giulia Agostinetto et al.
Andrea Galimberti et al.
Omics tools offer the opportunity to characterize and trace traditional and industrial fermented foods. Bioinformatics, through machine learning, and other advanced statistical approaches, are able to disentangle fermentation processes and ...
Marcus D Goncalves,Oliver Dk Maddocks
Marcus D Goncalves
Cancer cells acquire a diverse range of metabolic adaptations that support their enhanced rates of growth and proliferation. While these adaptations help tune metabolism to support higher anabolic output and bolster antioxidant defenses, th...
Unlocking the next generation of phage therapy: the key is in the receptors [0.03%]
解锁噬菌体疗法的下一代：关键在于受体
Fernando L Gordillo Altamirano,Jeremy J Barr
Fernando L Gordillo Altamirano
Phage therapy, the clinical use of viruses that kill bacteria, is a promising strategy in the fight against antimicrobial resistance. Before administration, phages undergo a careful examination of their safety and interactions with target b...
Metabolite salvage and restriction during infection - a tug of war between Toxoplasma gondii and its host [0.03%]
感染期间代谢物的回收与限制——粘液球虫与其宿主之间的拉锯战
Joachim Kloehn,Pierre-Mehdi Hammoudi,Dominique Soldati-Favre
Joachim Kloehn
The apicomplexans, including the coccidian pathogen Toxoplasma gondii, are obligate intracellular parasites whose growth and development are intricately linked to the metabolism of their host. T. gondii depends on its host for the salvage o...
Kent M Rapp,Jackson P Jenkins,Michael J Betenbaugh
Kent M Rapp
New technologies have allowed researchers to better design, build, and analyze complex consortia. These developments are fueling a wider implementation of consortium-based bioprocessing by leveraging synthetic biology, delivering on the fie...