Beyond calorie restriction: aging as a biological target for nutrient therapies [0.03%]
超越卡里限制：以营养疗法为目标作用的生物靶点老龄化问题
Steven N Austad,Jessica M Hoffman
Steven N Austad
Arguably, the most important discovery in the biology of aging to date was that simply reducing food intake extended life and improved many aspects of health in a diversity of animal species. The conventional wisdom that emerged from first ...
A dynamic understanding of cytochrome P450 structure and function through solution NMR [0.03%]
溶液核磁共振在细胞色素P450结构和功能动态研究中的应用
Thomas C Pochapsky
Thomas C Pochapsky
Many economically important biosyntheses incorporate regiospecific and stereospecific oxidations at unactivated carbons. Such oxidations are commonly catalyzed by cytochrome P450 monooxygenases, heme-containing enzymes that activate molecul...
Yiming Zhang,Jens Nielsen,Zihe Liu
Yiming Zhang
Biosynthesis of oleochemicals enables sustainable production of natural and unnatural alternatives from renewable feedstocks. Yeast cell factories have been extensively studied and engineered to produce a variety of oleochemicals, focusing ...
Beyond antibacterials - exploring bacteriophages as antivirulence agents [0.03%]
超越抗生素-探索噬菌体作为抗毒力剂的作用
Yang Shen,Martin J Loessner
Yang Shen
Life-threatening infections caused by multidrug-resistant bacteria are becoming increasingly difficult to treat. There is growing interest in exploiting bacteriophages (or phages) to combat bacterial infections. Phages often target bacteria...
Coordinating precursor supply for pharmaceutical polyketide production in Streptomyces [0.03%]
链霉菌中用于药物聚酮体产生的前体物质供应协调
Shanshan Li,Zilong Li,Shen Pang et al.
Shanshan Li et al.
The widely used polyketide pharmaceuticals in medicine and agriculture are mainly produced by Streptomyces species. These compounds, as secondary metabolites, are not involved in essential cellular processes and are usually produced during ...
Christiaan R de Vries,Qingquan Chen,Sally Demirdjian et al.
Christiaan R de Vries et al.
Bacteriophages have attracted extensive interest in vaccine design. This includes the use of phage display technology to select antigens, the use of engineered phages displaying target antigens in vaccine formulations, and phage DNA vaccine...
Enhancing phage therapy through synthetic biology and genome engineering [0.03%]
通过合成生物学和基因组工程增强噬菌体疗法
Bryan R Lenneman,Jonas Fernbach,Martin J Loessner et al.
Bryan R Lenneman et al.
The antimicrobial and therapeutic efficacy of bacteriophages is currently limited, mostly due to rapid emergence of phage-resistance and the inability of most phage isolates to bind and infect a broad range of clinical strains. Here, we dis...
Thekla Cordes,Christian M Metallo
Thekla Cordes
New small molecules are continuing to emerge as metabolically derived regulators of cell function. Itaconate is a recent example where endogenous mammalian synthesis was demonstrated only seven years ago. Since then, interest in the biochem...
The convergence of bacterial natural products from evolutionarily distinct pathways [0.03%]
来自进化上不同的途径的细菌天然产物的汇聚
Neil L Grenade,Graeme W Howe,Avena C Ross
Neil L Grenade
As bacteria readily convert simple starting materials into a diverse array of complex molecules with useful bioactivities, these microorganisms and their biosynthetic machinery represent attractive alternatives to traditional chemical synth...
Understanding the impact of age-related changes in the gut microbiome on chronic diseases and the prospect of elderly-specific dietary interventions [0.03%]
理解肠道微生物组年龄相关变化对慢性疾病的影响及老年人群特异性饮食干预的前景
Paola Pellanda,Tarini Shankar Ghosh,Paul W O&#x;Toole
Paola Pellanda
Ageing is associated with characteristic changes including a gradual decline of physiological functions, inflamm-aging, sarcopenia, and the associated onset of multiple diseases. Another factor potentially contributing to enhanced susceptib...