Julia R Flood,Caitlin A Mendina,Anjon Audhya
Julia R Flood
The early secretory pathway governs the transport of thousands of secreted and transmembrane proteins and lipids from the endoplasmic reticulum (ER) to juxtaposed ER-Golgi Intermediate Compartments (ERGIC). This process is largely directed ...
Multifaceted regulation of asymmetric cell division by the actin cytoskeleton [0.03%]
肌动蛋白细胞骨架对不对称细胞分裂的多层面调控
Peishan Yi,Guangshuo Ou,Wei Li
Peishan Yi
Asymmetric cell division (ACD) is essential for generating cell diversity in multicellular eukaryotes, yet the underlying mechanisms remain largely unresolved. Well-established models of ACD, such as microtubule-based spindle displacement i...
Jinghui Cao,Cai Liang,Hongtao Yu
Jinghui Cao
Aneuploidy is prevalent in cancer and has complicated roles in tumorigenesis. Paradoxically, artificially engineered aneuploidy in normal cells reduces cellular fitness by inducing proteotoxic and genotoxic stresses. A better molecular unde...
Matthew L Kutys,Robert Grosse
Matthew L Kutys
The functional organisation of the centromere and kinetochore during meiosis [0.03%]
减数分裂过程中着丝粒和动粒的功能组织形式
Lori B Koch,Adele L Marston
Lori B Koch
Meiosis generates gametes through a specialised cell cycle that reduces the genome by half. Homologous chromosomes are segregated in meiosis I and sister chromatids are segregated in meiosis II. Centromeres and kinetochores play central rol...
Camila Fernandes-Mariano,Joana N Bugalhão,Diana Santos et al.
Camila Fernandes-Mariano et al.
Recent technological advances in proteomics and microscopy techniques, such as cryo-electron microscopy (cryoEM) and expansion microscopy (ExM), have enhanced our understanding of centrosome structure, biogenesis, and regulation. Here we di...
Alice Amitrano,Debanik Choudhury,Konstantinos Konstantopoulos
Alice Amitrano
Cell migration through confined spaces is a critical process influenced by the complex three-dimensional (3D) architecture of the local microenvironment and the surrounding extracellular matrix (ECM). Cells in vivo experience diverse fluidi...
Amanda Bentley-DeSousa,Devin Clegg,Shawn M Ferguson
Amanda Bentley-DeSousa
Limited understanding of regulatory mechanisms controlling LRRK2 kinase activity has hindered insights into both its normal biology and how its dysregulation contributes to Parkinson's disease. Fortunately, recent years have yielded an incr...
Same but different: Centromere regulations in holocentric insects and plants [0.03%]
相同但不同：全着丝粒昆虫和植物的着丝粒调控机制
André Marques,Ines A Drinnenberg
André Marques
Centromeres are essential chromosomal regions responsible for ensuring proper chromosome segregation during cell division. Unlike monocentric chromosomes, which have a single centromeric region, holocentric chromosomes distribute centromeri...
Editorial overview: Fresh views on nuclear structure, function, and dynamics [0.03%]
评论概述：对核结构、功能和动力学的全新见解
Evi Soutoglou,Noriko Saitoh
Evi Soutoglou