Cancer-associated fibroblasts: Recent advances and therapeutic implications [0.03%]
癌症相关成纤维细胞：最近的研究进展及其治疗意义
Christina Paraskeva,Athanasia Stavropoulou,Vasiliki Koliaraki
Christina Paraskeva
The tumor microenvironment (TME) plays a crucial role in cancer initiation, progression, and metastasis, with cancer-associated fibroblasts (CAFs) representing one of the most abundant and influential stromal cell populations. Recent advanc...
Ras signalling at the actin cortex: Coordinating local and global changes to cell morphology [0.03%]
肌动蛋白细胞皮层中的Ras信号传导：协调局部和全局的细胞形态变化
Joe J Tyler,Helen K Matthews
Joe J Tyler
Ras proteins modulate key cellular signalling pathways and drive excessive proliferation when mutated in cancer. However, they also influence actin cytoskeleton organisation. In the model organism Dictyostelium, domains of active Ras patter...
Driving cancer: Motor and adaptor protein dysregulation in endocytic receptor signalling [0.03%]
驱动癌症：内吞受体信号转导中 motor 和 adapter 蛋白的失调
David H Kim,Shreya E Boby,Gregory M I Redpath et al.
David H Kim et al.
Receptor tyrosine kinases and other cell surface receptors are tightly regulated by endocytosis, which controls both the duration and spatial organisation of their downstream signalling. In cancers, altered internalisation and trafficking l...
Corrigendum to Exploring the dynamic behavior of leukocytes with zebrafish Curr Opin Cell Biol 85 December 2023 102276 [0.03%]
关于“利用斑马鱼探索白细胞动态行为（《当前意见：细胞生物学》杂志，2023年12月，卷85，文章号102276）”的勘误通知
Cassia Michael,Sofia de Oliveira
Cassia Michael
Published Erratum
Current opinion in cell biology. 2025 Nov 14:97:102599. DOI:10.1016/j.ceb.2025.102599 2025
Single-molecule biophysics in signaling: Functionality from stochastic effects [0.03%]
单分子生物物理在信号传导中的应用：随机效应的功能性
Jay T Groves
Jay T Groves
The growing ease with which single molecules can be visualized in living systems is providing a fantastic new view into the molecular processes of cellular signal transduction. The single-molecule perspective reveals stochastic variation an...
When two worlds collide: actin dynamics on endomembranes regulates membrane trafficking [0.03%]
当两个世界碰撞时：肌动蛋白动力学调控膜转运
Michelle F Marchan,James E Bear
Michelle F Marchan
Membrane trafficking is an essential aspect of cellular physiology, determining the spatial distribution of macromolecules within a cell in response to conditions such as nutrient availability and cellular stress. Much of this trafficking h...
Actin cytoskeleton protection by the formin-mediated safety valve [0.03%]
由formin介导的安全阀对肌动蛋白细胞骨架的保护作用
Fernando R Valencia,Sergey V Plotnikov
Fernando R Valencia
Mechanical forces shape cellular form and function by regulating key cellular processes; however, when dysregulated, they contribute to disease. Excessive forces can be detrimental to cells, damaging cytoskeleton, deforming nuclei, and even...
Tor Erik Rusten
Tor Erik Rusten
The first identified regulators of autophagy were the hormones Glucagon and Insulin, long before the recognition that they act through receptor-mediated cell signaling pathways. More than two decades since the identification of the autophag...
New insights into signaling networks coordinating epidermal stem cell regulation in skin regeneration and aging [0.03%]
调控皮肤再生和衰老的表皮干细胞调节的新见解
Mizuho Ishikawa,Hung Manh Phung,Thisakorn Dumrongphuttidecha et al.
Mizuho Ishikawa et al.
The skin is a dynamic, regenerative organ capable of withstanding diverse internal and external stresses, supported by tissue-resident stem cells. A complex signaling network regulates interactions between epidermal stem cells, dermal cells...
From images to understanding: Advances in deep learning for cellular dynamics analysis [0.03%]
从图像到理解：细胞动力学分析的深度学习进展
Benjamin Woodhams,Virginie Uhlmann
Benjamin Woodhams
Deep learning (DL) has revolutionized bioimage analysis, enabling unprecedented insights into cellular dynamics. This review provides an overview of state-of-the-art DL approaches for quantifying cellular dynamics from 2D microscopy images,...