Rabs in the driving seat: Coordinating vesicular traffic and membrane contact site dynamics [0.03%]
拉卜掌舵：协调囊泡运输和膜接触位点动态性
Yogita Phogat,Sankalita Paul,Mahak Sharma
Yogita Phogat
Rab GTPases are central regulators of intracellular membrane organization, ensuring the specificity and directionality of vesicular transport. Operating as 'molecular switches,' Rab GTPases cycle between an active GTP-bound and an inactive ...
Boldizsár Vámosi,Balázs Enyedi
Boldizsár Vámosi
Chemoattractant gradients guide cell migration in immunity, tissue repair, and development, yet their spatial and temporal distribution remains difficult to measure. In this review, we discuss how the field is moving beyond static source ma...
Tribbles pseudokinases: Fine tuning of cell signaling with implications in metabolism, inflammation and cancer [0.03%]
拟激酶蛋白Tribbles：调控细胞信号通路及其在代谢、炎症和癌症中的作用
Guillermo Velasco,Mar Lorente
Guillermo Velasco
Within the family of protein kinases there is a subgroup of 'evolutionarily related members of the total human kinome' that are devoid (or have very limited) enzymatic activity. These proteins, so-called pseudokinases, play important functi...
The orchestration of ciliary opus: Interplay of signalling molecules, GTPases, and trafficking machinery [0.03%]
纤毛营运：信号分子、GTP酶和转运装置的相互作用
Ravikant Piyush,Pujarini Giri,Swapnil Rohidas Shinde
Ravikant Piyush
Primary cilia are sensory organelles that host various signalling receptors and proteins to coordinate signalling pathways essential for tissue homeostasis. This review explores the molecular mechanisms by which intraflagellar transport (IF...
Philippe Chavrier,J Christopher Fromme
Philippe Chavrier
Ibtissem Nabti,George T Shubeita
Ibtissem Nabti
Eukaryotic cells rely on long-range microtubule transport to accurately position mitochondria, and other organelles and vesicles with spatial and temporal precision. While kinesin and dynein motors drive directional movement, motor activity...
Mechanosensing in immune cells: Implications for migration and beyond [0.03%]
免疫细胞中的机械感应：对迁移及其更多方面的启示
Isabel Calvente,Vincent Calmettes,Elnaz Nematollahi et al.
Isabel Calvente et al.
Effective immune surveillance and host defense require leukocytes to patrol their environment and rapidly respond to threats. Traditionally, immune cells detect inflammatory or pathogenic cues that guide them to sites of infection or tissue...
Rituraj Marwaha,Tamal Das
Rituraj Marwaha
Cell migration is a fundamental biological process essential for development, tissue repair, and cancer metastasis. While cytoskeletal dynamics, adhesion turnover, and biochemical signalling are known regulators of migration, intracellular ...
You-Hsuan Liu,Elena Scarpa
You-Hsuan Liu
Cells in tissues often navigate complex environments, encountering physical obstacles which impose mechanical confinement. The nucleus -the largest organelle of the eukaryotic cell-is emerging as a key platform for integrating mechanical si...
Patterns in motion: Choreographing dynamic cell behaviours during tissue repair [0.03%]
动作中的模式：组织修复过程中编排细胞动态行为
Helen Weavers
Helen Weavers
Tissue repair is a dynamic, multicellular response that relies on the precise spatiotemporal coordination of diverse cell types. Here, we discuss how recent advances have accelerated our mechanistic understanding of these collective cellula...