Beyond mechanosensing: How cells sense and shape their physical environment during development [0.03%]
超越机械感受：细胞在发育过程中如何感知和塑造其物理环境
Matyas Bubna-Litic,Roberto Mayor
Matyas Bubna-Litic
The role of mechanics as a regulator of cell behaviour and embryo development has been widely recognised. However, much of the focus in mechanobiology during embryo development has been on how the mechanical properties of a cell affect its ...
Nanoscale mechano-adaption of integrin-based cell adhesions: New tools and techniques lead the way [0.03%]
基于整合素的细胞粘附物的纳米力学适应性：新工具和新技术引领发展之路
Ryosuke Nishimura,Pakorn Kanchanawong
Ryosuke Nishimura
Force generation and transmission in biological systems are driven by protein-based machinery organized at the nanoscale. Thus, technological advances that allow for the measurement or manipulation of molecular-scale features are key to new...
Inter-organ communication in Drosophila: Lipoproteins, adipokines, and immune-metabolic coordination [0.03%]
果蝇器官间的交流：脂蛋白，脂肪激素和免疫代谢的协调
Akhila Rajan,Jason Karpac
Akhila Rajan
Inter-organ communication networks are essential for maintaining systemic homeostasis in multicellular organisms. In Drosophila melanogaster, studies of adipokines and lipoproteins reveal evolutionarily conserved mechanisms coordinating met...
Structuring of the endolysosomal system by HOPS and CORVET tethering complexes [0.03%]
HOPS和CORVET衔接复合体对内溶酶体系结构的构建作用
Christian Ungermann,Arne Moeller
Christian Ungermann
Eukaryotic cells depend on their endolysosomal system for membrane protein and organelle turnover, plasma membrane quality control, or regulation of their nutrient uptake. All material eventually ends up in the lytic environment of the lyso...
Hyojun Kim,Morgan Delarue
Hyojun Kim
The cytoplasm is a dense and complex milieu in which a plethora of biochemical reactions occur. Its structure is not understood so far, albeit being central to cellular functioning. In this review, we highlight a novel perspective in which ...
Learning physics and biology from cytoskeletal and condensate interactions [0.03%]
细胞骨架与凝聚体相互作用中的物理和生物学规律探究
Julia Bourdeau,Prashali Chauhan,Jennifer L Ross
Julia Bourdeau
Two important mechanisms for self-organization in cells include condensation of biomolecules, such as proteins and nucleic acids into phase-separated droplets to form membraneless organelles and organization of the cytoskeletal filaments in...
Bryce A Brownfield,J Christopher Fromme
Bryce A Brownfield
The Golgi complex is the central sorting station of eukaryotic cells. Several unique trafficking pathways direct the transport of proteins between the Golgi and the endoplasmic reticulum, plasma membrane, and endolysosomal system. In this r...
Xiao Wang,Tiantian Li,Yusong Guo et al.
Xiao Wang et al.
The secretory pathway, which begins at the endoplasmic reticulum (ER) through the COPII complex, is responsible for transporting proteins and lipid carriers to various destined cellular compartments or extracellular space. The fundamental m...
Catharina Küng,Michael Lazarou,Thanh Ngoc Nguyen
Catharina Küng
Mitophagy is an important lysosomal degradative pathway that removes damaged or unwanted mitochondria to maintain cellular and organismal homeostasis. The mechanisms behind how mitophagy is initiated to form autophagosomes around mitochondr...
Aurélie Dobric,Christopher J Tape
Aurélie Dobric
Cellular phenotypes are regulated by dynamic signalling processes that involve proteins, post-translational modifications, epigenetic events, and transcriptional responses. Functional perturbation studies are required to understand cell sig...