Chromosomal instability in development and disease: Beyond cancer evolution [0.03%]
染色体不稳定性在发育和疾病中的作用：超越癌症进化
Marco Milán
Marco Milán
Chromosomal instability (CIN), an increased rate of changes in chromosome structure and number, has been classically associated with human disease as a way of evolving the cancer genome. In recent years, three additional research lines conc...
Robert G Parton,Lois S Weisman
Robert G Parton
The power of connections: Recent advances in understanding the regulation of mitochondrial dynamics by membrane contact sites [0.03%]
连接的力量——线粒体动态通过膜接触位点调节的最新进展
Jason C Casler,Laura L Lackner
Jason C Casler
The continuous remodeling of the mitochondrial network through fusion, fission, transport, and turnover events, collectively known as mitochondrial dynamics, is essential for the maintenance of mitochondrial metabolic and genomic health. Wh...
Mitotic signalling in progenitor cells: Integrating cell division with cell specification [0.03%]
干细胞有丝分裂信号传导：将细胞分裂与细胞分化相整合
Torcato Martins,Yuu Kimata
Torcato Martins
Mitotic signalling mediated by cell cycle regulators (CCRs) is pivotal for coordinating cell division and fate specification across metazoans. CCRs, including cyclin-dependent kinases and ubiquitin ligases, use post-translational modificati...
Condensate-membrane interactions shape membranes, tune cytoskeletal assembly, and localize mRNAs [0.03%]
凝聚物-膜相互作用塑造细胞膜、调节细胞骨架组装并定位mRNA
Wilton T Snead
Wilton T Snead
Biomolecular condensates have emerged as essential subcellular compartments. Although condensates organize biochemistry without a delimiting membrane, condensates frequently interact with membrane surfaces in diverse cellular contexts. Cond...
Peng Shi,Yuhan Zhang,Congying Wu
Peng Shi
Mitochondria undergo dynamic adaptations to cellular energy demands, changing morphology and function, through active interactions with other cellular organelles and the cytoskeletons. With advances in light and electron microscopy, actin p...
Julia Eckert,Virgile Viasnoff,Alpha S Yap
Julia Eckert
Cells are active mechanical objects: they are subject to forces, exert force, and interpret changes in force as biological information. We now understand much about how this occurs at the molecular and single-cell level. We also appreciate ...
Huimin Pan,Honggang Su,Xun Huang
Huimin Pan
Lipid droplets (LDs) are highly conserved organelles found across a wide range of organisms, from prokaryotic to eukaryotes. LD proteins are a diverse group of proteins that are associated with LDs, regulating various aspects of LD function...
Preet Manchanda,Anja Geitmann
Preet Manchanda
The plant cell wall is a dynamic envelope crucial for cell structure. Recent insights highlight the pivotal roles of RAPID ALKALINIZATION FACTOR (RALF) peptides, LEUCINE-RICH REPEAT EXTENSINS (LRX), and the FERONIA (FER) receptor kinase in ...
Deb Sankar Banerjee,Shiladitya Banerjee
Deb Sankar Banerjee
Intracellular organelles are essential for cellular architecture and function, and their size regulation is critical for maintaining cellular homeostasis. Organelle size often scales with cell size, governed by mechanisms that integrate res...