Evolution of the cytoskeleton: Emerging clues from the diversification and specialisation of archaeal cytoskeletal proteins [0.03%]
细胞骨架的进化：来自古菌细胞骨架蛋白分化和特化的线索
Hannah J Brown,Vinaya D Shinde,Leonardo Bosi et al.
Hannah J Brown et al.
Recent research in archaeal cell biology has revealed a remarkable diversity of cytoskeletal proteins related to those found in bacteria and eukaryotes, such as the tubulin, actin, and ESCRT protein superfamilies, and archaea-specific prote...
Apical constriction in morphogenesis: From actomyosin architecture to regulatory networks [0.03%]
顶点收缩在形态发生中的作用：从肌动蛋白肌球蛋白骨架结构到调控网络
Samara N Ranie,Melanie D White
Samara N Ranie
Apical constriction is a key morphogenetic process driving tissue remodelling throughout life, including early developmental events. Once thought to occur through uniform actomyosin ring contraction, it is now recognized as a dynamic proces...
Rachel J Kehrberg,Kris A DeMali
Rachel J Kehrberg
Upon engagement of E-cadherin or when mechanical force is applied, E-cadherin recruits cytoskeletal proteins and triggers various signal transduction cascades including PI3K, Src, Rho family GTPases, kinases, YAP/TAZ, AMPK, and other metabo...
Elvira Nikalayevich,Noemi Zollo,Marie-Hélène Verlhac
Elvira Nikalayevich
Oocytes are female gametes specialized in storing maternal RNAs, proteins, lipids, and metabolites essential for embryonic development after fertilization, sometimes for decades in humans. To support this extended lifespan, oocytes have evo...
"Cancer progression through systemic signaling viewed from Drosophila" [0.03%]
“果蝇研究揭示癌症进展的系统信号传导机制”
Masato Enomoto,Shizue Ohsawa
Masato Enomoto
Cancers develop through local interactions between tumor cells and neighboring cells within the tissue micro environment, while distinct organs regulate cancer progression and suppression via systemic factors. Recent studies in Drosophila h...
Recent advances in spying on cell signaling with fluorescent biosensors [0.03%]
用于窥探细胞信号转导的荧光生物传感器的研究进展
Qian-Yi Zhang,Sohum Mehta,Jin Zhang
Qian-Yi Zhang
Cells routinely orchestrate the activities of diverse biochemical pathways to sustain cellular function and proliferation, as exemplified by their ability to faithfully convert extracellular signals into specific intracellular responses. Th...
Nutrient sensing and signalling of specific amino acids: Insights from Drosophila study [0.03%]
果蝇实验中的特定氨基酸的营养感知和信号转导新模式
Ayano Oi,Fumiaki Obata
Ayano Oi
Maintaining amino acid (AA) homeostasis is necessary for organisms. To achieve this, organisms have evolved various signalling pathways regulated by sensing general or specific AA levels. Recently, advances in genetic and dietary manipulati...
RAS/ERK signaling and PLK1: Coordinating developmental regulation and disease mechanisms [0.03%]
RAS/ERK信号传导和PLK1：协调发育调节和疾病机制
Han Bit Baek,Swathi Arur
Han Bit Baek
The RAS/ERK signaling pathway is a critical regulator of cellular processes such as proliferation, differentiation, and survival, core mechanisms that drive development. Dysregulation of RAS/ERK signaling is implicated in developmental diso...
Rene Gonzalez,Danny Reinberg
Rene Gonzalez
The Notch signaling pathway is essential for cell fate decisions and maintaining epigenetic memory during nervous system development. It regulates neural stem cell maintenance, neuronal-glial differentiation, and neural circuit formation. N...
Shamphavi Sivabalasarma,Marleen van Wolferen,Sonja-Verena Albers et al.
Shamphavi Sivabalasarma et al.
The archaeal S-layer represents one of the most ancient and versatile cell surface structures, playing critical roles in maintaining cellular integrity, mediating environmental interactions, and enabling cellular flexibility. Recent advance...