Jessica A Cross,Derek N Woolfson,Mark P Dodding
Jessica A Cross
Cells depend on a complex and precisely regulated subcellular organization, largely driven by the cytoskeleton and motor proteins that control intracellular transport. This review explores innovative strategies to manipulate cellular archit...
Cancer-associated fibroblasts as mediators of tissue microenvironment remodeling in cancer [0.03%]
癌相关成纤维细胞在癌症组织微环境重塑中的作用
Fernanda G Kugeratski,Emily J Kay,Sara Zanivan
Fernanda G Kugeratski
Cancer-associated fibroblasts (CAFs) are a multifunctional cell population of solid tumors that substantially remodel the tumor microenvironment (TME). The combination of single-cell and spatial technologies with elegant mouse models and an...
Chloé Colson,Frederick Jh Whiting,Ann-Marie Baker et al.
Chloé Colson et al.
In this review, we argue that mathematical modelling is an essential tool for understanding cancer cell evolution and phenotypic plasticity. We show that mathematical models enable us to reconstruct time-dependent tumour evolutionary dynami...
Signaling mechanisms in the reactivation of quiescent neural stem cells in Drosophila [0.03%]
调控静息状态神经干细胞重新激活的信号机制研究——以果蝇为例
Mahekta R Gujar,Hongyan Wang
Mahekta R Gujar
Neural stem cells (NSCs) play a central role in the nervous system development and regeneration. In the adult mammalian brain, most NSCs remain in a quiescent state, but they can exit quiescence and become active, leading to the generation ...
Theresia E B Stradal,Micaela Boiero Sanders,Peter Bieling
Theresia E B Stradal
Arp2/3 complex is a central actin filament generator driving numerous motile processes in cells. It was originally isolated from Acanthamoeba approx. 30 years ago. It is highly conserved throughout eukaryotic life and composed of 7 subunits...
Nikoloz Tsikolia,Dinh Thach Lam Nguyen,Yee Han Tee
Nikoloz Tsikolia
Establishment of left-right (LR) asymmetry relies on a multistep interplay of molecular signaling and physical processes. Initial LR symmetry breaking in several model vertebrates was shown to take place at the LR organizer (LRO) where chir...
Hui Tu,Haibin Wang,Huaqing Cai
Hui Tu
Macropinocytosis is a conserved pathway for non-selective bulk uptake of extracellular fluid. It plays important roles in various cellular processes, including nutrient acquisition in Dictyostelium and cancer cells and antigen sampling by i...
Tae Yeon Yoo,Bernardo Gouveia,Daniel Needleman
Tae Yeon Yoo
A great deal is known about biochemical aspects of transcription, but we still lack an understanding of how transcription is causally regulated in space and time. A major unanswered question is the extent to which transcription at different...
Advances in single-cell omics: Transformative applications in basic and clinical research [0.03%]
单细胞组学进展：基础研究与临床应用中的变革性影响
Mohammed Inayatullah,Anuj Kumar Dwivedi,Vijay K Tiwari
Mohammed Inayatullah
Recent advancements in single-cell RNA sequencing, spatial transcriptomics, and multi-omics integration have enabled researchers to dissect complex tissues and identify distinct cell populations with unique functional states. This review di...
From brain-sparing to prioritised tumour growth: Insights into tumour-host interactions [0.03%]
从脑保护到优先肿瘤生长：探讨肿瘤与宿主相互作用的见解
Qian Dong,Louise Y Cheng
Qian Dong
Cellular responses to their environment are shaped not only by genetic composition but also by interactions with neighbouring cells. Beyond local interactions, inter-organ crosstalk has emerged as a crucial mechanism coordinating tissue gro...