Asma Majoul,Ana J Garcia-Saez
Asma Majoul
There are many ways for a cell to die, but each cell only dies once, causing an inherent variability that results from common triggers activating interconnected signaling networks that diverge at key decision points during cell death initia...
Christoph Anton,Franziska Lautenschläger,Rhoda J Hawkins
Christoph Anton
Here we give an overview of recent theoretical and experimental work on modeling the mechanics and dynamics of the cytoskeleton. The cytoskeleton is a multicomponent, complex and active material that is essential to cell mechanics and dynam...
Syed N Barmaver,Guoqiang Gu,Irina Kaverina
Syed N Barmaver
Pancreatic β cells are essential for glucose homeostasis through the regulated secretion of insulin in response to rising glucose levels. A critical component of this process is the precise and timely positioning of insulin secretory granu...
Victoria Sanz-Moreno,Boon Chuan Low
Victoria Sanz-Moreno
Mechanisms of transmembrane domain recognition during endoplasmic reticulum quality control [0.03%]
内质网质量控制过程中跨膜结构域识别机制
Nikita Sergejevs,Pedro Carvalho
Nikita Sergejevs
Misfolded proteins can be toxic to cells, and their accumulation is a hallmark of diseases such as neurodegeneration. Normally, protein homeostasis is maintained by quality control processes that eliminate misfolded proteins. In the endopla...
Epigenetic regulation of DUX4: From embryogenesis to muscular degeneration [0.03%]
DUX4的表观遗传调控：从胚胎发育到肌肉退行性变性疾病
Leyi Li,Arnab Ray,Shifeng Xue
Leyi Li
DUX4 is a transcription factor with a critical role in zygotic genome activation. It is expressed briefly in early embryogenesis and shut off for the rest of life. Inappropriate reactivation of DUX4 in adult muscle cells causes facioscapulo...
KASH proteins transform from passive tethers to dynamic conductors of motor-driven nuclear dynamics [0.03%]
KASH蛋白从核被动牵拉者到主动驱动者的转变参与了细胞分裂中期到后期的转换过程中的染色体排列和胞质分裂等重要事件
G W Gant Luxton,Selin Gümüşderelioğlu,Kassandra M Ori-McKenney et al.
G W Gant Luxton et al.
Nuclear-cytoskeletal coupling orchestrates critical cellular processes from migration to tissue organization. At the core of this machinery, outer nuclear membrane Klarsicht/ANC-1/SYNE homology (KASH) proteins function as sophisticated mole...
Mechanisms of cellular fitness and cell competition: Towards an integrated view [0.03%]
细胞适应性和细胞竞争的机制：迈向整合观点
Jules Lavalou,Karyna Kulakova,Yogaspoorthi J Subramaniam et al.
Jules Lavalou et al.
Cell competition is a fundamental mechanism of tissue quality control that enables the selective elimination of less fit, mis-specified, diseased or aged cells. By shaping tissue composition, it plays a critical role in development, organis...
Leveraging phylogenetic diversity: Cellular dynamics in non-model organisms [0.03%]
利用系统发育多样性：非模型生物的细胞动态学
Sarah L Guest,Arthur T Molines
Sarah L Guest
Cell biologists use a severely undersampled population of eukaryotes as model organisms to infer cellular processes across an immense diversity. In consequence, mechanisms are defined in only a few lineages. Here, we highlight cellular beha...
Cytoskeletal scaffolding of NaVs and KVs in neocortical pyramidal neurons: Implications for neuronal signaling and plasticity [0.03%]
新皮层锥体神经元中Navs和KVs的细胞骨架支架：对神经信号传导和可塑性的影响
Carina C Elvira,Paul M Jenkins
Carina C Elvira
The initiation and propagation of action potentials (APs) depend on the precise localization of voltage-gated sodium (NaV) and potassium (KV) channels in neurons. In neocortical pyramidal neurons, NaV1.2 and NaV1.6 are key at the axon initi...