Structure-resolved virus-host interactomics by cross-linking mass spectrometry [0.03%]
通过交联质谱解析结构特异性病毒-宿主互作组学
Boris Bogdanow,Fan Liu
Boris Bogdanow
Viruses depend on host protein networks to replicate, assemble progeny, and spread between cells and organisms. Defining these virus-host protein interactions is challenging because they are highly dependent on infection stage, cell type, s...
Structure-resolved virus-host interactomics by cross-linking mass spectrometry [0.03%]
基于交联质谱的结构解析型病毒宿主互作组学研究
Boris Bogdanow,Fan Liu
Boris Bogdanow
Viruses depend on host protein networks to replicate, assemble progeny, and spread between cells and organisms. Defining these virus-host protein interactions is challenging because they are highly dependent on infection stage, cell type, s...
Nir Hananya,Hyun-Woo Rhee
Nir Hananya
Current advances in stereoselective chemical O-glycosylation for the synthesis of glycans [0.03%]
选择性化学O-糖基化研究的最新进展——用于合成寡糖分子
Weiping Zhou,Weizhun Yang,Biao Yu
Weiping Zhou
Stereoselective chemical glycosylation represents the key steps for the construction of structurally well-defined glycans and glycoconjugates, which are essential for interrogating their biological functions and developing carbohydrate-base...
Nature-inspired macrocyclic peptides: Discovery and molecular engineering for drug development [0.03%]
受自然启发的环肽：用于药物开发的发现和分子工程
Greta Bergamaschi,Giulia Lodigiani,Stefano Gandolfi et al.
Greta Bergamaschi et al.
Natural cyclic peptides have long served as a rich reservoir of bioactivity, occupying a unique region of the drug space that bridges the gap between small molecules and large biologics. Evolution has perfected the macrocyclic architecture ...
Matúš Gajdoš,Guangcai Xu,Samuel Molyneux et al.
Matúš Gajdoš et al.
Peptides are widely used as therapeutics and in many other important applications. However, current chemical synthesis of peptides is highly step- and atom-inefficient, requiring deleterious reagents and solvents, which creates harmful wast...
Mu-Rong Kao,Hsiang-Ling Hsu,Yves S Y Hsieh
Mu-Rong Kao
Carbohydrates play essential roles in biological systems, where structural diversity and glycan-mediated interactions govern molecular recognition, immune responses, and tissue organization. These features provide a foundation for nature-in...
Lasse Middendorf,Noelia Ferruz
Lasse Middendorf
Sparked by innovations in generative artificial intelligence (AI), the field of protein design has undergone a paradigm shift with an explosion of new models for optimizing existing enzymes or creating them from scratch. After more than one...
Design principles for molecular Raman sensors: A sea of opportunities [0.03%]
分子拉曼传感器的设计原理——广阔的应用前景展望
Sujit Kumar Das,Arijit Chakraborty,Ankona Datta
Sujit Kumar Das
Molecular Raman sensors come with an unprecedented opportunity and promise of allowing simultaneous imaging and tracking of multiple bioanalytes in living cells. How can we achieve this dream goal for molecular imaging? Careful and strategi...
Lighting up mitochondrial membranes: Reading and writing the physical state of the inner mitochondrial membrane [0.03%]
点亮线粒体膜：阅读和书写内线粒体膜的物理状态
Gaurav Singh,Sunil Laxman
Gaurav Singh
The mitochondrial inner membrane (IMM) is depicted as a scaffold housing the enzymes of the electron transport chain, allowing electron transfer and generation of the electrochemical gradient that drives respiration and adenosine triphospha...