Mapping subcellular microenvironments using oligonucleotide-directed proximity labeling [0.03%]
采用寡核苷酸定向邻近标记法绘制细胞内微环境图谱
Scott A Schactler,Nicholas G Skiados,Amol A Gajendragadkar et al.
Scott A Schactler et al.
Understanding how cells compartmentalize their biomolecules into discrete structures remains one of the fundamental goals of cell biology. The proliferation of proximity labeling (PL) technologies has been invaluable toward this goal, enabl...
Jasper S Dumalaog,Shang-Cheng Hung
Jasper S Dumalaog
Glycosaminoglycans (GAGs) are complex carbohydrates ubiquitously expressed on cell surfaces and within the extracellular matrix, where they regulate essential biological processes through sequence- and sulfation-dependent interactions. Majo...
Structure-resolved virus-host interactomics by cross-linking mass spectrometry [0.03%]
通过交联质谱解析结构特异性病毒-宿主互作组学
Boris Bogdanow,Fan Liu
Boris Bogdanow
Viruses depend on host protein networks to replicate, assemble progeny, and spread between cells and organisms. Defining these virus-host protein interactions is challenging because they are highly dependent on infection stage, cell type, s...
Structure-resolved virus-host interactomics by cross-linking mass spectrometry [0.03%]
基于交联质谱的结构解析型病毒宿主互作组学研究
Boris Bogdanow,Fan Liu
Boris Bogdanow
Viruses depend on host protein networks to replicate, assemble progeny, and spread between cells and organisms. Defining these virus-host protein interactions is challenging because they are highly dependent on infection stage, cell type, s...
Nir Hananya,Hyun-Woo Rhee
Nir Hananya
Current advances in stereoselective chemical O-glycosylation for the synthesis of glycans [0.03%]
选择性化学O-糖基化研究的最新进展——用于合成寡糖分子
Weiping Zhou,Weizhun Yang,Biao Yu
Weiping Zhou
Stereoselective chemical glycosylation represents the key steps for the construction of structurally well-defined glycans and glycoconjugates, which are essential for interrogating their biological functions and developing carbohydrate-base...
Nature-inspired macrocyclic peptides: Discovery and molecular engineering for drug development [0.03%]
受自然启发的环肽：用于药物开发的发现和分子工程
Greta Bergamaschi,Giulia Lodigiani,Stefano Gandolfi et al.
Greta Bergamaschi et al.
Natural cyclic peptides have long served as a rich reservoir of bioactivity, occupying a unique region of the drug space that bridges the gap between small molecules and large biologics. Evolution has perfected the macrocyclic architecture ...
Matúš Gajdoš,Guangcai Xu,Samuel Molyneux et al.
Matúš Gajdoš et al.
Peptides are widely used as therapeutics and in many other important applications. However, current chemical synthesis of peptides is highly step- and atom-inefficient, requiring deleterious reagents and solvents, which creates harmful wast...
Mu-Rong Kao,Hsiang-Ling Hsu,Yves S Y Hsieh
Mu-Rong Kao
Carbohydrates play essential roles in biological systems, where structural diversity and glycan-mediated interactions govern molecular recognition, immune responses, and tissue organization. These features provide a foundation for nature-in...
Lasse Middendorf,Noelia Ferruz
Lasse Middendorf
Sparked by innovations in generative artificial intelligence (AI), the field of protein design has undergone a paradigm shift with an explosion of new models for optimizing existing enzymes or creating them from scratch. After more than one...