Interphase chromatin biophysics and mechanics: new perspectives and open questions [0.03%]
有丝分裂间期染色质的生物物理和力学：新视角与未解之谜
Antoine Coulon
Antoine Coulon
The physical organization and properties of chromatin within the interphase nucleus are intimately linked to a wide range of functional DNA-based processes. In this context, interphase chromatin mechanics - that is, how chromatin, physicall...
Mo-Fan Huang,Megan E Fisher,Trinh T T Phan et al.
Mo-Fan Huang et al.
Cancer research remains clinically unmet in many areas due to limited access to patient samples and the lack of reliable model systems that truly reflect human cancer biology. The emergence of patient-derived induced pluripotent stem cells ...
Ervin Ascic,Carlos-Filipe Pereira
Ervin Ascic
Antigen-presenting cells (APCs) are a heterogenous group of immune cells composed by dendritic cells (DCs) and macrophages (Mϕ), which are critical for orchestrating immunity against cancer or infections. Several strategies have been explo...
Beyond genomic weaving: molecular roles for CTCF outside cohesin loop extrusion [0.03%]
基因组编织之外：CTCF在cohesin环挤出过程以外的分子作用
Aaron Corin,Elphège P Nora,Vijay Ramani
Aaron Corin
CCCTC-binding factor (CTCF) is a key regulator of 3D genome organization and transcriptional activity. Beyond its well-characterized role in facilitating cohesin-mediated loop extrusion, CTCF exhibits several cohesin-independent activities ...
Nicolò Caporale,Oliviero Leonardi,Carlo Emanuele Villa et al.
Nicolò Caporale et al.
The collection of Homo sapiens anatomical hallmarks hypothesized to support the 'human condition' did not appear at one specific time and place, but gradually, creating a reticulate evolutionary trajectory. The recent reconstruction of migr...
Rethinking chromatin accessibility: from compaction to dynamic interactions [0.03%]
重新思考染色质的可接近性：从压缩到动态相互作用
Tom Fillot,Davide Mazza
Tom Fillot
The genome is traditionally divided into condensed heterochromatin and open euchromatin. However, recent findings challenge this binary classification and the notion that chromatin condensation solely governs the accessibility of transcript...
Runhua Yang,Fen Ji,Jianwei Jiao
Runhua Yang
The nervous system is the most complex system in the human body, and the normal development of the central nervous system (CNS) is essential for maintaining the healthy life activities of the individual. CNS development requires the orchest...
Xinyi Liu,Xiaoru Ling,Qi Tian et al.
Xinyi Liu et al.
Totipotent stem cells, the earliest cells in embryonic development, can differentiate into complete embryos and extra-embryonic tissues, making them essential for understanding both development and regenerative medicine. This review examine...
Roles of intrinsically disordered protein regions in transcriptional regulation and genome organization [0.03%]
固有无序蛋白区域在转录调控和基因组组织中的作用
Jiapei Miao,Shasha Chong
Jiapei Miao
Eukaryotic transcription is a complex process regulated by transcription factors (TFs), coactivators, and RNA polymerase machineries, many of which contain sizable intrinsically disordered regions (IDRs). Many TFs activate transcription thr...
Inferring human phenotypes using ancient DNA: from molecules to populations [0.03%]
利用古DNA推断人类表型：从分子到人群
Manuel Ferrando-Bernal,Colin M Brand,John A Capra
Manuel Ferrando-Bernal
The increasing availability of ancient DNA (aDNA) from human groups across space and time has yielded deep insights into the movements of our species. However, given the challenges of mapping from genotype to phenotype, aDNA has revealed le...