Ashlesha Gogate,Maria H Chahrour
Ashlesha Gogate
Neurogenomics has provided exceptional insights into the genetic architecture underlying autism spectrum disorder (ASD), which is increasingly understood as a collection of individually rare disorders. This review synthesizes current advanc...
Chromosome organization by Structural Maintenance of Chromosomes complexes in C. elegans [0.03%]
秀丽新杆线虫中染色体结构维持复合物的组织方式
Sinem Erkan,Kalyan Ghadage,Peter Meister
Sinem Erkan
Genome folding is a key regulator of transcription, chromosome segregation, and genome stability. In Caenorhabditis elegans, chromatin folding strategies have diverged from those observed in mammals or flies, resulting in the absence of vis...
Cooperativity between regulatory elements acts as a modulator of enhancer function [0.03%]
调控元件间的协同作用充当了增强子功能的调节因子
Deevitha Balasubramanian,Margarita Masoura,Yad Ghavi-Helm
Deevitha Balasubramanian
Transcription is classically known to be regulated by two key elements, promoters and enhancers. While these remain central to gene regulation, it is now clear that additional regulatory sequences fine-tune enhancer function and transcripti...
Giada Forte,Chris A Brackley,Nick Gilbert et al.
Giada Forte et al.
The cell nucleus is a dynamic environment where ATP-driven processes - like transcription, replication, and epigenetic modifications - continually drive the genome far from thermodynamic equilibrium. Recent interdisciplinary efforts combini...
Revitalizing psychopharmacology in the GWAS era: the potential of barcoded screening in drug discovery [0.03%]
在GWAS时代振兴精神药理学：药物发现中条形码筛选的潜力
Sebastian H Heesen,Man-Hsin Chang,Michael C Wehr et al.
Sebastian H Heesen et al.
The success of comprehensive genome-wide association studies has substantiated the multigenetic origin of most mental disorders, including schizophrenia, bipolar disorder, and major depression. Non-coding genetic variants are enriched mainl...
Tuo Shi,Xin Jin
Tuo Shi
Although there are many known risk alleles associated with adult-onset psychiatric disorders such as schizophrenia [1-4], bipolar disorder [5-7], and major depressive disorder [8-10], the mechanistic links between these risk alleles and dis...
Integrating machine learning and functional genomics to study cross-species gene regulatory evolution [0.03%]
结合机器学习和功能基因组学研究跨物种基因调控进化问题
Erin N Gilbertson,Steven K Reilly
Erin N Gilbertson
Understanding the genetic basis of phenotypic differences across species has been a longstanding goal of evolutionary biology since Darwin. While a recent proliferation of mammalian genomes has provided an unprecedented inventory of sequenc...
Elias T Friman,Wendy A Bickmore
Elias T Friman
Transcriptional regulation involves the binding of thousands of transcription factors (TFs) to hundreds of thousands of enhancers and promoters. How do the collective activities of these proteins and cis-regulatory elements achieve precise ...
Mix-and-match between transposable elements and zinc finger proteins fuels genic and regulatory innovation [0.03%]
转座子与锌指蛋白的混合匹配推动了基因和调控创新
Olga Rosspopoff,Didier Trono,Cédric Feschotte
Olga Rosspopoff
Transposable elements (TEs) are abundant and dynamic components of eukaryotic genomes, subject to regulation by equally adaptive regulatory systems. A coevolution of TEs and zinc finger genes can be documented throughout metazoan evolution....
Ricardo Muñiz-Trejo,Jaeda Ej Patton,Santiago Herrera-Álvarez et al.
Ricardo Muñiz-Trejo et al.
New methods are revealing the character of epistatic interactions within proteins and their impacts on evolution. Variation in biochemical phenotypes across protein sequences is determined primarily by the context-independent effects of ami...