Long-term evolution of regulatory DNA sequences. Part 1: simulations on global, biophysically-realistic genotype-phenotype maps [0.03%]
Elia Mascolo,Réka Borbély,Santiago Herrera-Álvarez et al.
Elia Mascolo et al.
Promoters and enhancers are cis-regulatory elements (CREs), DNA sequences that bind transcription factor (TF) proteins to up- or down-regulate target genes. Decades-long efforts yielded TF-DNA interaction models that predict how strongly an...
Jiamiao Yuan,Xuerui Zeng,Jichao Yin et al.
Jiamiao Yuan et al.
Primates exhibit distinctive cognitive and behavioral repertoires relative to many other mammals. These capabilities are not associated with the emergence of entirely new cortical structures, but rather with coordinated evolutionary modific...
Chromatin mechanics and regulatory protein function: insights from single-molecule force spectroscopy [0.03%]
染色质力学和调控蛋白功能：单分子力谱学的见解
Noam Nago,Ariel Kaplan
Noam Nago
Single-molecule force spectroscopy probes chromatin mechanics by resolving force-induced conformational transitions across multiple length scales. Recent studies extend these measurements beyond canonical nucleosomes to chromatin assembled ...
Parama Mitra,Shubha Tole
Parama Mitra
The cerebral cortex contains functionally distinct neuronal and glial cell types. Neurogenesis precedes gliogenesis, but the mechanisms that operate in progenitors, how the production of astrocytes and oligodendrocytes is regulated, and reg...
RNA signaling in cellular plasticity during homeostasis and regeneration [0.03%]
稳态与再生过程中细胞可塑性的 RNA 信号转导
Ajai C Nagaraj,Ehsan P Ahi,Minna-Liisa Änkö et al.
Ajai C Nagaraj et al.
Cells and tissues constantly read and broadcast information through RNA. This mini-review explores how endogenous and damage-released RNAs act as instructive signals that rewire cell identity during steady-state homeostasis and injury repai...
The emergence of neurogenic lineage motifs in building the vertebrate retina [0.03%]
脊椎动物视网膜的构建中神经元谱系模式的出现
Mei Wang,Jie He
Mei Wang
How does a single pool of progenitors generate the remarkable diversity of retinal neurons? This review synthesizes the molecular and lineage logic underlying this process. By integrating single-cell sequencing studies across multiple devel...
SOX9 as a key regulator of tissue remodelling and epithelial cell fate transitions [0.03%]
SOX9在组织重塑和上皮细胞命运转变中的关键调控作用
Maria T Bejar,Maria P Alcolea
Maria T Bejar
Epithelial plasticity allows committed cells to bypass rigid differentiation hierarchies, enabling efficient tissue repair through the reactivation of developmental-like programmes. In this review, we focus on the transcription factor SOX9 ...
Max Minne,Keiko Sugimoto
Max Minne
Plant regeneration exemplifies the remarkable developmental plasticity of plants, yet how regenerative programs are initiated and spatially restricted after damage has remained unclear. Recent work supports a damage-first model in which wou...
Tuba Majid,Elif Eroglu
Tuba Majid
Heart function is tightly coupled to mechanical forces acting on cardiac cells, which are converted into intracellular signals that regulate gene expression and cellular behavior. While dysregulation of these forces contributes to cardiovas...
Sergey Isaev,Igor Adameyko
Sergey Isaev
Multipotent progenitors that appear phenotypically similar often differ in the range of cell types they generate, which is typically described as fate bias. Traditional bulk lineage-tracing approaches, such as Cre/Lox systems, established q...