Michael Ziller,Hyejung Won
Michael Ziller
The role of transposable elements-endogenous retroviruses in embryonic development and regeneration [0.03%]
转座元件-内源性逆转录病毒在胚胎发育和再生中的作用
Ziyan Li,Yixin Huang,Zhenyu Ju et al.
Ziyan Li et al.
Endogenous retroviruses (ERVs) are dynamically regulated across the lifespan and can function as context-dependent components of host gene-regulatory networks. During embryonic development, selected ERV-derived elements are co-opted to supp...
What's in a niche? Elucidating the role of the ECM in cell fate commitment [0.03%]
细分为何物？阐明基质在细胞命运决定中的作用
Atoosa Amel,Anna Alemany
Atoosa Amel
Emerging work is shedding light on how integrin engagement can be harnessed to modulate cell behaviour by deepening our understanding of the downstream signalling cascades activated upon extracellular matrix (ECM) binding. In many culture s...
Somatic mutations: recent advances in brain aging and neurodegeneration [0.03%]
体细胞突变：近期脑衰老与神经退行性疾病研究的进展
Stephanie R Oatman,August Y Huang,Michael B Miller
Stephanie R Oatman
Somatic mutations are genetic variants that occur after the single-cell phase of development and have been implicated in disease pathogenesis. While most DNA lesions are detected and repaired, examination of healthy tissue has revealed that...
Seungseok Kang,Yujin Oh,Sangwoo Kim
Seungseok Kang
The human brain is a genomic mosaic, where postzygotic mutations arising from embryogenesis to senescence drive diverse neurodevelopmental and neurodegenerative diseases. Because of numerous sequencing artifacts at ultralow variant allele f...
Minchul Kim,Yu Xin Wang,Nour El Khazen
Minchul Kim
Skeletal muscle exhibits an unusually complex architecture, in which large multinucleated myofibers accommodate a small population of resident muscle stem cells (MuSCs) along their surface. In addition, myofibers contain molecularly and fun...
Eunah Kim,Bon-Kyoung Koo
Eunah Kim
The gastrointestinal tract possesses a remarkable regenerative capacity to maintain tissue homeostasis against various injuries. However, the intestine and stomach exhibit distinct regenerative strategies. In the intestine, damage to Lgr5-p...
Luca Giorgetti,Daniel Jost
Luca Giorgetti
Translational cell fate reprogramming and regenerative medicine enabled by microphysiological systems [0.03%]
基于微生理系统的小分子细胞重编程和再生医学
Hrithiha Sriramulu,Hyunsung Woo,Anavi Kaul et al.
Hrithiha Sriramulu et al.
Recent advances in genetic engineering and in vivo reprogramming have opened transformative possibilities for controlling cell fate in tissue repair and regeneration. However, clinical translation remains constrained by the limited predicti...
Noriyuki Shinagawa,Tracy A Bedrosian
Noriyuki Shinagawa
Somatic variants accumulate in human brain cells throughout the lifespan. Variant allele fraction has traditionally been used as a proxy for both the developmental timing of somatic variants and their functional effect, based on the assumpt...