Mix-and-match between transposable elements and zinc finger proteins fuels genic and regulatory innovation [0.03%]
转座子与锌指蛋白的混合匹配推动了基因和调控创新
Olga Rosspopoff,Didier Trono,Cédric Feschotte
Olga Rosspopoff
Transposable elements (TEs) are abundant and dynamic components of eukaryotic genomes, subject to regulation by equally adaptive regulatory systems. A coevolution of TEs and zinc finger genes can be documented throughout metazoan evolution....
Ricardo Muñiz-Trejo,Jaeda Ej Patton,Santiago Herrera-Álvarez et al.
Ricardo Muñiz-Trejo et al.
New methods are revealing the character of epistatic interactions within proteins and their impacts on evolution. Variation in biochemical phenotypes across protein sequences is determined primarily by the context-independent effects of ami...
New methodological approaches and insights gained toward understanding the evolved human skeleton [0.03%]
了解人类骨骼进化的新方法和见解
Gayani Senevirathne,Terence D Capellini
Gayani Senevirathne
Modern humans exhibit marked musculoskeletal changes when compared to those of our African ape relatives, such as chimpanzees, bonobos, and gorillas. These changes reflect adaptive shifts during hominin evolution in spine, pelvis, knee, and...
Editorial overview: Molecular and genetic basis of disease (2025): post-transcriptional regulation of neurodevelopment and associated disorders [0.03%]
主编按语：疾病分子和遗传学基础（2025）：神经发育的转录后调控及其相关障碍
Naiara Akizu,Jozef Gecz
Naiara Akizu
Evolutionary genetics meets ecological immunology: insights into the evolution of immune systems [0.03%]
进化基因学遇见生态免疫学：论免疫系统的进化中的启示
Alexander E Downie,Jenny Tung
Alexander E Downie
Immune genes show remarkably consistent evidence of selection, modification, and diversification across the tree of life. Parasites are a key force in this process, but many questions remain about the genetic and phenotypic targets of paras...
Human gut evolution: insights from stem cell models and single-cell genomics [0.03%]
人体肠道进化：类器官模型和单细胞基因组学研究的新视野
Rubén López-Sandoval,Stefano Secchia,Joep Beumer et al.
Rubén López-Sandoval et al.
The gastrointestinal (GI) tract evolved in response to dietary changes and pathogen exposures that varied throughout history. As a major interface between the host and environment, the GI epithelia have evolved specialized barrier and immun...
Andres Bendesky
Andres Bendesky
Recent advances in single-cell genomics are propelling a flurry of discoveries about the cellular composition of the brain and other organs across species. These discoveries, coupled with experimental manipulations, have begun to reveal how...
Iain Mathieson
Iain Mathieson
Ancient DNA has revolutionized our understanding of human history and clarified many aspects of human evolution on a molecular level. In this article, I describe recent efforts to translate this into descriptions of phenotypic change over t...
Genome instability in mammalian embryos implications for genome editing, development, and evolution [0.03%]
哺乳动物胚胎中的基因组不稳定性和其对基因编辑、发育和进化的意义
Xiangyi Liu,Shuangyi Xu,Dieter Egli
Xiangyi Liu
Genomic instability is a significant challenge in early mammalian development and a cause for developmental failure and abnormalities, particularly in humans. Here, we review our knowledge and explore its significance of genome instability ...
Evolution of comparative transcriptomics: biological scales, phylogenetic spans, and modeling frameworks [0.03%]
比较转录组学的演变：生物尺度、系统发育跨度和建模框架
Matteo Zambon,Federica Mantica,Mafalda Dias et al.
Matteo Zambon et al.
Comparative transcriptomic studies are key to understanding how molecular evolution drives phenotypic divergence across the tree of life. Here, we discuss three major directions in which the field of comparative transcriptomics is evolving....