Raphaëlle Dubruille,Béatrice Horard,Benjamin Loppin
Raphaëlle Dubruille
The global replacement of nucleosomes with nonhistone chromosomal proteins during sperm differentiation is a widespread phenomenon in sexually reproducing animals. In mammals, for instance, sperm chromatin is essentially packaged with prota...
Gregory C Gundberg,Jeremy Nance
Gregory C Gundberg
The mitochondrial genome (mtDNA) can accumulate deleterious mutations that lead to disease. Animals have evolved strategies to eliminate mtDNA mutations in the maternal germ line, increasing the likelihood that their progeny inherit healthy...
Madelyn A Gillentine
Madelyn A Gillentine
The HNRNP gene family has long been investigated in neurodegenerative disorders and cancer. Over the last several years, multiple members of the gene family have been associated with neurodevelopmental disorders. To date, there are nine wel...
Addressing missing context in regulatory variation across primate evolution [0.03%]
填补灵长类进化过程中调控差异中的缺失环节
Genevieve Housman,Audrey Arner,Amy Longtin et al.
Genevieve Housman et al.
In primates, loci associated with adaptive trait variation often fall in noncoding regions. Understanding the mechanisms linking these regulatory variants to fitness-relevant phenotypes remains challenging but can be addressed using functio...
Wei-Han Lin,Aliaksandr Damenikan,Yves Barral
Wei-Han Lin
Budding yeast undergoes replicative aging through asymmetric cell divisions. Yeast mother cells progressively age as they generate successive daughter cells, until they ultimately die. However, their daughters are born rejuvenated, that is,...
Amélie Piton
Amélie Piton
NOVA1 and NOVA2 are neuron-specific RNA-binding proteins essential for alternative splicing (AS), influencing neurodevelopment by regulating transcript diversity. These proteins recognize YCAY sequences on pre-mRNA, regulating exon inclusio...
Lauren Tracy,Zhao Zhang
Lauren Tracy
Transposons, or 'jumping genes', are ubiquitous genomic elements with the dual capacity to drive evolutionary innovation and disrupt genome integrity through gene mutation and DNA damage. Their activity is particularly significant in germli...
Lineage-specific regulatory evolution: insights from massively parallel reporter assays [0.03%]
谱系特异性调控元件的进化研究：大规模并行报告系统的新见解
Ryder Easterlin,Nadav Ahituv
Ryder Easterlin
Lineage-specific genetic variants play a key role in evolutionary divergence, particularly through changes in cis-regulatory elements that fine-tune gene expression. Massively parallel reporter assays (MPRAs) provide a powerful approach to ...
Transcriptional adaptation: where mRNA decay meets genetic compensation [0.03%]
转录适应：mRNA降解与遗传补偿的交汇点
Lara Falcucci,Brian Juvik,Didier Yr Stainier
Lara Falcucci
Nonsense-mediated mRNA decay (NMD) is a translation-coupled quality control mechanism that safeguards cells against faulty transcripts that could lead to truncated and potentially harmful proteins. However, we posit that there is another si...
Rewiring for movements in meiotic prophase: regulators, roles, and evolutionary pathways [0.03%]
减数分裂前期运动的调控、功能及进化路径
Wenxin Xie,Manjunath Gowder,Dominic Bazzano et al.
Wenxin Xie et al.
Meiotic prophase movement and chromosome bouquet formation are highly conserved processes and essential features of meiosis, yet their functional components and dependencies vary among organisms. A key feature of meiotic prophase is that ch...