Genetic disruption of nonsense-mediated mRNA decay in neurodevelopmental disorders [0.03%]
神经发育障碍中 nonsense mediated mRNA decay的遗传破坏
Saba Montazaribarforoushi,Lachlan A Jolly
Saba Montazaribarforoushi
Nonsense-mediated mRNA decay (NMD) is a translation-dependent mRNA decay mechanism that serves the purpose of controlling both mRNA quality and quantity. As a quality control mechanism, NMD protects organisms against the deleterious effects...
Editorial overview: 3Rs update: a new era in cellular identity and therapeutic plasticity [0.03%]
简报：3RS更新——细胞身份和治疗塑性的新时代
Peng Du,Jianlong Wang
Peng Du
Bibhusita Pani,Evgeny Nudler
Bibhusita Pani
The primary objective of life is to ensure the faithful transmission of genetic material across generations, despite the constant threat posed by DNA-damaging factors. To counter these challenges, life has evolved intricate mechanisms to de...
Leon Hilgers,Michael Hiller
Leon Hilgers
Comparative genomics is a powerful approach to illuminate the genetic basis of phenotypic diversity across macro-evolutionary timescales. Recent advances in sequencing, genome assembly, annotation, and comparative methods promoted large-sca...
Dynamic three-dimensional epigenomic reorganization for the development of undifferentiated spermatogonia in mice [0.03%]
小鼠未分化精原细胞发育过程中的动态三维表观基因组重构
Masahiro Nagano,Mitinori Saitou
Masahiro Nagano
Germ cells are unique in their ability to acquire totipotency. Toward this end, they reorganize their three-dimensional (3D) epigenome during their development, including epigenetic reprogramming in primordial germ cells that differentiate ...
Abigail Lind
Abigail Lind
The microbial community colonizing the animal gut includes all domains of life, including eukaryotic microbes. Historically viewed as pathogens, increasing evidence has revealed that many protists are commensal members of the microbiome wit...
Why and how paternal mitochondrial DNA gets cut out of the inheritance [0.03%]
为何以及父系线粒体DNA是如何被清除出遗传的
Mayu Shimomura,Thomas R Hurd
Mayu Shimomura
Mitochondrial DNA (mtDNA) is inherited maternally across animals, yet the evolutionary rationale behind this unusual mode of inheritance remains a longstanding mystery. Understanding the processes that prevent the transmission of paternal m...
Rudrarup Bhattacharjee,Shreya Agarwala,Danielle Mazurkiewicz et al.
Rudrarup Bhattacharjee et al.
The genomic information is insulated in the nucleus of all eukaryotic cells. Error-free transcription needs to be followed by an efficient export of the messenger RNAs (mRNA) to facilitate the regulated synthesis of proteins for carrying ou...
Shiyu Li,Hui Shen,Bing Peng et al.
Shiyu Li et al.
As the origin of the development, a fertilized egg owns the ability to generate a whole new organism, including both embryonic and extraembryonic tissues, representing the highest developmental potency, totipotency. For more than 40 years, ...
Marta Grzonka,Ben E Black,Michael A Lampson
Marta Grzonka
Centromeres are essential for genome inheritance, serving as sites for kinetochore assembly and for final sister chromatid cohesion to ensure accurate chromosome segregation during cell division. These roles must persist through radical phy...