Insights and perspectives into the discovery of complement-related biomarkers in cancer [0.03%]
关于癌症相关补体生物标志物研究的见解与观点
Daniel Ajona,Janire Debersaques,Ruben Pio
Daniel Ajona
The complement system, a central component of innate immunity, is implicated in tumor biology, influencing processes such as tumor progression, immune evasion, and response to therapy. Numerous studies have identified alterations in complem...
Yaqin Yu,Yueqi Qiu,Ming Zhao
Yaqin Yu
Inflammatory memory refers to the ability of an organism to mount a stronger or faster response upon re-exposure to similar inflammatory stimuli. This heightened sensitivity was once thought to be a unique characteristic of immune cells. Ho...
Immunological complications of blood transfusion: current insights and advances [0.03%]
输血免疫并发症：当前的认识和进展
Naveen Bansal,Manish Raturi,Charu Singh et al.
Naveen Bansal et al.
Blood transfusion is integral to modern medicine but carries significant immunological risks. This review outlines key immune-mediated complications, including acute hemolytic transfusion reactions from ABO incompatibility, and febrile nonh...
Can we cure vasculitis? [0.03%]
我们可以治愈血管炎吗？
Meghan E Free,Dominic J Ciavatta,Ronald J Falk
Meghan E Free
As with all autoimmune diseases, antineutrophil cytoplasmic autoantibody (ANCA) vasculitis cannot be cured by a singular approach. This complexity arises because autoimmune conditions typically result from multiple hits to the immune system...
Complement system modulation in age-related macular degeneration: navigating failures, building future successes [0.03%]
年龄相关性黄斑变性中的补体系统调节：回顾失败，展望未来成功之路
Aliénor Vienne-Jumeau,Elodie Bousquet,Francine Behar-Cohen
Aliénor Vienne-Jumeau
Age-related macular degeneration (AMD) is a leading cause of irreversible central vision loss in elderly populations across developed countries. Complement system dysregulation has been implicated in AMD onset and evolution. Complement inhi...
Martin F Bachmann,Mona O Mohsen,Daniel E Speiser
Martin F Bachmann
In order to stay circulating in the human population over many years, viruses need to adapt to the environment, mainly to the host's immune response, allowing for reinfection despite preexisting immunity. These different viral strategies ar...
Friend or foe? - Janus Langerhans cells in skin immunity and promising clinical application [0.03%]
朋友还是敌人？皮肤免疫中的Janus朗格汉斯细胞及有前景的临床应用
Mengjiao Chen,Shiyi Yan,Jun Li et al.
Mengjiao Chen et al.
Langerhans cells (LCs), the professional antigen-presenting cells in the epidermis, serve as the first line of defense in the skin's immune system. With advancements in detection technologies and the development of diverse animal models, LC...
Armando Curto,Laura Cristoferi,Marco Carbone et al.
Armando Curto et al.
Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease affecting the intra- and extra-hepatic bile ducts, leading to progressive inflammation and fibrosis. Its pathogenesis is complex and involves genetic predispo...
Stacie L Lin,Michael C Carroll
Stacie L Lin
In systemic lupus erythematosus (SLE), chronic autoimmunity and sustained inflammation can lead to the development of neuropsychiatric lupus (NPSLE) in up to 80% of patients. Elevated interferon-alpha (IFNα) is detected in serum and cerebr...
Insights into platelet post-transfusional human leukocyte antigen I immunization [0.03%]
输注血小板后人类白细胞抗原I型免疫反应的研究进展
Gabriel Rojas-Jiménez,Blandine Maître
Gabriel Rojas-Jiménez
Although human leukocyte antigen (HLA) class I alloimmunization is asymptomatic, it nevertheless introduces a degree of complexity in the context of transplantation or allogeneic transfusion. In practice, it is evidenced by the presence of ...