Federica Defendi,Axelle Amen,Giovanna Clavarino et al.
Federica Defendi et al.
C1 Inhibitor (C1INH) is a crucial regulator of multiple plasmatic pathways, including complement, coagulation, kallikrein-kinin systems, and fibrinolysis. C1INH deficiency results in the downstream overproduction of the vasoactive peptide b...
Human inborn errors of type I interferon-independent intrinsic immunity in nonleukocytic cells [0.03%]
非白细胞固有免疫中I型干扰素独立的先天性缺陷病人类病例
Shen-Ying Zhang,Jean-Laurent Casanova,András N Spaan
Shen-Ying Zhang
'Intrinsic immunity' is often used to refer to mechanisms of host defense operating in nonleukocytic cells. This term can refer to the intrinsic capacity of an individual cell to fend off invading microbes without help from other cells or o...
Karol Bączek,Wojciech J Piotrowski,Francesco Bonella
Karol Bączek
Purpose of review: Diagnosing sarcoidosis remains challenging. Histology findings and a variable clinical presentation can mimic other infectious, malignant, and autoimmune diseases. This review synthesizes current eviden...
Zihan Ma,Richard W Pierce,Carrie L Lucas et al.
Zihan Ma et al.
Endothelial cells (ECs) integrate immune and vascular functions to promote host defense against pathogens. While previously studied as forming passive flow conduits, ECs are now recognized as active contributors to maladaptive inflammation....
Transfusion-related acute lung injury: experimental models to study pathogenesis and therapeutic strategies [0.03%]
输血相关性急性肺损伤：探讨其发病机制和治疗策略的实验模型
Farahnaz Rayatdoost,Rick Kapur
Farahnaz Rayatdoost
Transfusion-related acute lung injury (TRALI) is a life-threatening complication of blood transfusion, with mortality rates exceeding 40% in critically ill patients. Despite its clinical severity, TRALI pathogenesis remains unclear, leaving...
Emerging novel therapies for steroid-refractory acute graft-versus-host disease: recent advances and future directions [0.03%]
类固醇难治性急性移植物抗宿主病新疗法的最新进展和未来方向
Yishan Ye,Wenjing Hao,Florent Malard et al.
Yishan Ye et al.
Acute graft-versus-host disease (aGVHD) is a significant complication of allogeneic hematopoietic cell transplantation (allo-HCT), characterized by immune-mediated tissue damage from donor immune cells. Standard treatment of aGVHD involves ...
Carson E Moseley,Joseph J Sabatino Jr,Scott S Zamvil
Carson E Moseley
The role of B cells in central nervous system (CNS) autoimmunity was initially highlighted by successful clinical trials of anti-CD20 monoclonal antibodies in multiple sclerosis (MS). Research in MS as well as in aquaporin 4 (AQP4)-IgG+ neu...
Angelo D&#x;Alessandro,James C Zimring
Angelo D&#x;Alessandro
Purpose of review: This review summarizes recent advances in metabolomics that have enhanced our understanding of transfusion-related immunomodulation (TRIM), highlighting how biochemical changes in stored blood products ...
Kimberly A Thomas,Rachael P Jackman
Kimberly A Thomas
The rising interest in using cold-stored platelets (CSP) for improving outcomes in patients with active bleeding has led to multiple clinical trials with the goal of determining the in vivo hemostatic efficacy of CSP compared to standard-of...
Lewis W Yu,Elaine Y Hsiao
Lewis W Yu
Bidirectional communication between the gut microbiota and neuroimmune system is essential during host-microbiome interactions. Recent research has begun to unravel microbiome-neuroimmune crosstalk and suggest classical neurochemicals as ke...