Beyond randomized clinical trials in pediatric rheumatology: exploring the potential of target trial emulation [0.03%]
儿科风湿病研究中的随机对照试验之外：目标试验模拟的潜在价值探索
Alessandra Alongi,Carlo Alberto Scirè,Nicholas Bakewell et al.
Alessandra Alongi et al.
Real-world data (RWD) from nonrandomized clinical settings, such as registries and observational cohorts, can be used to address research questions for which randomized controlled trials (RCTs) are not feasible or appropriate. However, thes...
Recurrent pericarditis in children: evidence, controversies, and emerging perspectives [0.03%]
儿童复发性心包炎：证据、争议与展望
Angela Mauro,Paola Baldassarre,Marianna Zicoia et al.
Angela Mauro et al.
Recurrent pericarditis complicates approximately one-third of initial pericarditis episodes in children. Once considered a postinfectious sequel, it is now understood as an autoinflammatory disorder sustained by dysregulated interleukin-1 s...
Alexander Tepper,Trung Nguyen,Chiara Falcomatà et al.
Alexander Tepper et al.
Spatial transcriptomic and proteomic atlases have enabled mapping of gene programs within intact tissues, but these measurements remain largely descriptive and do not define the mechanisms controlling tissue biology. Pooled CRISPR screening...
Spatial metabolic heterogeneity shapes CD8+ T cell function in cancer [0.03%]
空间代谢异质性塑造了癌症中的CD8+t细胞功能
Peio Azcoaga,Ilaria Elia
Peio Azcoaga
Tumors are spatially heterogeneous ecosystems in which malignant, stromal, vascular, and immune cells interact within metabolically distinct niches. These localized microenvironments are shaped by factors such as nutrient availability, hypo...
From rheumatology to dermatology: cytokine signaling pathways as therapeutic targets at the skin-joint interface in inflammatory diseases: a narrative review [0.03%]
从风湿病学到皮肤病学：炎症性疾病下皮肤关节交界面处细胞因子信号转导途径作为治疗靶点的叙事性综述
Marco Cattalini,Paolo Amerio,Davide Bertolla et al.
Marco Cattalini et al.
Over the last two years, inflammatory dermatology has undergone a transition from morphology-based classification toward pathway-driven immune endotyping. Atopic dermatitis, psoriatic disease, and hidradenitis suppurativa have emerged as pa...
Wilfred Ifeanyi Umeojiako,Vasileios Kouranos,Rakesh Sharma
Wilfred Ifeanyi Umeojiako
Cardiac sarcoidosis is a potentially fatal inflammatory disorder with the tendency to mostly affect the myocardial tissues. It is commonly associated with extra-cardiac structures such as the lungs and the thoracic lymph nodes; however, whe...
María J Mercado-Celin,Marcela Patiño-Arboleda,Lady J Rios-Serna et al.
María J Mercado-Celin et al.
Human endogenous retroviruses (HERVs) comprise approximately 8% of the human genome and were long regarded as inert remnants of ancestral retroviral infections. Increasing evidence indicates that HERVs are active genomic elements capable of...
Siba P Raychaudhuri,Smriti K Raychaudhuri,Disha Chakraborty
Siba P Raychaudhuri
Once considered incurable, psoriasis is now being re-evaluated in light of sustained, drug-free remissions, prompting a redefinition of 'cure' as long-term/drug-free remission. Psoriatic disease is primarily driven by dysregulation of the i...
Calcium signaling in microglial immune functions: current understanding and implications for disease [0.03%]
钙信号在小胶质细胞免疫功能中的作用：当前理解及其对疾病的影响
Alex R Lifton,Kaitlyn E DeMeulenaere,Murali Prakriya
Alex R Lifton
Microglia are the resident innate immune cells of the brain that play essential roles in immune surveillance, phagocytosis, and neuroinflammatory responses. A central regulator of these diverse functions is intracellular Ca2+ signaling, whi...
The role of artificial intelligence in clinical trials in adult and pediatric rheumatology [0.03%]
人工智能在成人和儿科风湿病临床试验中的作用
Saverio La Bella,Ana Isabel Rebollo-Giménez,Alessandra Alongi et al.
Saverio La Bella et al.
The development of clinical trials is limited by high costs and methodological complexities. In this context, artificial intelligence (AI) is emerging as a key instrument for their optimization. In the early phases of study design and recru...