Immune dyshomeostasis in lifestyle-associated diseases: a new paradigm for personalized medicine and prevention [0.03%]
Peter Duewell,Andreas Diefenbach,Eicke Latz
Peter Duewell
Non-communicable diseases, including metabolic, inflammatory, and malignant disorders, now dominate global morbidity and mortality. These chronic, lifestyle-associated diseases expose the limits of strategies focused on suppressing late-sta...
Samuel D Stampfer,Alexandra W Dretler,Rama R Amara
Samuel D Stampfer
Mpox is a smallpox-like disease caused by the monkeypox virus. In 2022, a global outbreak of mpox resulted in more than 113 000 cases. Just a year later, a different strain of mpox caused the largest ever outbreak in Africa, with over 46 00...
A critical look at the evolution of randomized controlled trials: new and old ethical issues [0.03%]
Hasan Yazici,Yesim Ozguler,Sinem N Esatoglu et al.
Hasan Yazici et al.
The traditional randomized controlled trial (RCT), a most valuable tool of evidence-based medicine, is rapidly evolving into new forms. The main reason behind this evolution is the basic explanatory nature of RCT and the related need for re...
Functional interactions of Kv1.3 channels in microglia and T cells and their implications in neurodegeneration [0.03%]
Dilpreet Kour,Upasna Srivastava,Trinity Eddy et al.
Dilpreet Kour et al.
Kv1.3 is a voltage-gated potassium channel expressed on immune cells. It functions in coordination with calcium channels to maintain cellular homeostasis. Several studies support important roles for Kv1.3 in microglia-driven neuroinflammati...
Margaret E Feeney
Margaret E Feeney
We are at the dawn of a new era in the biomedical prevention of childhood malaria. The successful development and ongoing rollout of the first malaria vaccines, RTS,S/AS01E and R21/Matrix-M, have injected much-needed optimism into the malar...
P2 purinergic receptors in systemic lupus erythematosus: from experimental findings to therapeutic perspectives [0.03%]
Yves Renaudineau,Wesley Brooks
Yves Renaudineau
P2 purinergic receptors are activated by extracellular adenosine triphosphate and other nucleotides released during inflammatory processes, cellular stress responses, and amplification by NETosis, thereby serving as pivotal mediators of bot...
Current role of ATG in GVHD prevention: optimizing post-transplantation outcomes through combination with PTCY [0.03%]
ATG在GVHD预防中的作用及与PTCY联合应用以优化移植预后的作用
Maria Liga,Dimitrios Tsokanas,Angeliki N Georgopoulou et al.
Maria Liga et al.
Graft versus host disease (GVHD) is one of the major complications of allogeneic hematopoietic cell transplantation (allo-HCT), contributing significantly to post-transplant morbidity and mortality. Anti-thymocyte globulin (ATG) is a widely...
Antonio Tonutti,Saverio D&#x;Amico,Suraj Timilsina et al.
Antonio Tonutti et al.
The complexity and heterogeneity of autoimmune diseases are only partially captured by current analytic tools, even when deep learning techniques are employed to intercept patterns beyond existing dogma. Synthetic data offer a newer paradig...
Autoimmunity beyond antibodies: alternative roles of beta-2-glycoprotein I in and out of antiphospholipid syndrome? [0.03%]
超出抗体的自身免疫：β2-糖蛋白I在和不在抗磷脂综合征中的作用？
Claudia Grossi,Imogen Ih Buckle,Thomas Cr McDonnell
Claudia Grossi
The term autoimmune disease refers to autoantibody-dependent pathophysiological conditions, in which characterising the autoantibodies is essential, as is studying their target(s), the (auto)antigen(s), which represent the other side of the...
Ruiming Zhao,Steve An Goldstein
Ruiming Zhao
Voltage-gated proton channels (Hv1) are key regulators of microglial activation, coupling proton extrusion to reactive oxygen species production, cellular pH homeostasis, and pro-inflammatory signaling. Dysregulated Hv1 activity exacerbates...