Vivin Kokuhennadige,Elizabeth Aitken,Stephen Rogerson
Vivin Kokuhennadige
Malaria during pregnancy continues to compromise maternal, fetal, and subsequently infant health. This burden has increased in Africa, though it has decreased elsewhere. Here, we provide a concise review of recent findings on malaria in pre...
Patterns and trends in sarcoidosis: an epidemiological perspective [0.03%]
从流行病学角度看 sarcoidosis 的模式和趋势
Ogugua N Obi,Elizabeth V Arkema,Yvette C Cozier
Ogugua N Obi
The incidence, prevalence, and burden of sarcoidosis is increasing worldwide. The Nordic countries have the highest incidence with lowest rates reported in Asia. In the United States, Black females have the highest incidence and prevalence ...
Evaluating the pandemic potential of Zika virus in a changing global landscape [0.03%]
从全球范围审视扎伊尔埃博拉病毒疫情潜在的大流行病风险
Soumba Traore,Sophia C Chima,Kristina M Adams Waldorf et al.
Soumba Traore et al.
As of 2024, the World Health Organization declared the Zika virus (ZIKV), an emerging flavivirus, as a high-priority pathogen with the potential to cause future Public Health Emergencies of International Concern. Although the last major out...
A comprehensive study on the effect of alglucosidase alpha and immunomodulation on survival, motor and cardiac outcome, creatine kinase and antibody titers in classic infantile Pompe disease: the Monza experience [0.03%]
α- glucosidase和免疫调节对经典婴儿型庞培病生存率、运动及心脏结局、肌酸激酶和抗体滴度影响的全面研究：蒙扎经验
Martha C Faraguna,Viola Crescitelli,Sonia Bonanomi et al.
Martha C Faraguna et al.
We report on 13 classic infantile Pompe patients, including four cross-reactive immunological material negative (31%), treated with alglucosidase alpha (rhGAA) at Fondazione IRCCS San Gerardo, Monza, between 2003 and 2024. Median age at rhG...
Vivienne Kahlmann,Donald Simon,Marlies S Wijsenbeek et al.
Vivienne Kahlmann et al.
Patients with sarcoidosis can present with a wide range of symptoms that impact their quality of life (QoL). QoL represents one of the most important treatment priorities for patients. Therefore, measuring what matters to patients is of gre...
Alaa Elsaghir,Torsten Witte
Alaa Elsaghir
Primary Sjögren's disease (SjD) is a systemic autoimmune disorder where diagnosis relies on the presence of Ro/SS-A and La/SS-B autoantibodies. However, approximately one-third of SjD patients are seronegative, often requiring an invasive ...
Elderly-onset rheumatoid arthritis as a distinct entity: mechanisms, manifestations, and treatment [0.03%]
老年发病类风湿关节炎：机制、临床表现及治疗策略
Shiliang Ma,Xinran Wu,Xuan Zhang et al.
Shiliang Ma et al.
Elderly-onset rheumatoid arthritis (EORA), defined as onset at ≥60 years, is a clinically distinct and increasingly prevalent subset of rheumatoid arthritis (RA). This review synthesizes evidence that EORA is not merely late-onset RA but a...
A critical look at animal and cellular models in autoinflammatory diseases [0.03%]
论自身炎症性疾病中的动物和细胞模型
Yohei Kirino,Mitsuhiro Takeno
Yohei Kirino
Autoinflammatory diseases (AIDs) comprise a diverse group of conditions arising from dysregulated immune control due to congenital or acquired genetic abnormalities in innate immune pathways, and patients typically require lifelong treatmen...
Daan Peeters,Mathieu Vinken,Raf Van Campenhout
Daan Peeters
Cellular channels consisting of pannexins facilitate signaling between the intracellular and extracellular environment. In this respect, pannexin channel opening serves as a pivotal trigger for both inflammatory processes and cell death. Wh...
The role of stromal cell immunobiology in understanding and managing Sjögren's disease [0.03%]
stromal细胞免疫生物学在理解及治疗Sjögren病中的作用
Valeria Manfrè,Luca Quartuccio,Sara S McCoy
Valeria Manfrè
Sjögren's disease (SjD) is a systemic, heterogeneous autoimmune disorder, clinically dominated by dryness symptoms resulting from inflammatory infiltration of exocrine glands. To date, no validated and resolutive therapeutic strategies are...