Composite and pragmatic measures in psoriatic arthritis: bridging trials and clinical feasibility [0.03%]
复合和实用措施在银屑病关节炎中的应用：试验与临床可行性之间的桥梁措施
Ji-Hyoun Kang,Laura C Coates
Ji-Hyoun Kang
Purpose of review: Psoriatic arthritis (PsA) is a multidomain inflammatory disease where no instrument captures the full spectrum of activity or its impact on patients' lives. Accurate outcome measurement is essential for...
Evolution and prospects for the definition of clinically useful endpoints in Sjögren disease [0.03%]
Sjögren综合征临床结局指标的定义及其前景
Maxime Beydon,Simon J Bowman,Raphaèle Seror
Maxime Beydon
Outcomes in Sjögren disease (SjD) have ranged from diverse symptom scales to the validated EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI) and EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI), which now provide a common ...
Antimicrobial peptides and proteins as rheostats of intestinal homeostasis and immunity [0.03%]
肠上皮源性抗菌肽和蛋白作为肠道稳态和免疫的调节因子
Talia Akoh-Arrey,John F Brooks nd
Talia Akoh-Arrey
Antimicrobial peptides and proteins (AMPs) function as molecular rheostats of host-microbe interactions and cell-intrinsic defense. Rather than being binary effectors, they act along a continuum. At basal levels, AMPs maintain harmony with ...
T cells in Sjögren's disease: update on their role in salivary gland pathogenesis and treatment [0.03%]
Sjögren病的T细胞：其在唾液腺发病机制和治疗中的作用最新研究进展
Gwenny M Verstappen,Sarah Pringle,Kornelis Sm van der Geest et al.
Gwenny M Verstappen et al.
Sjögren's disease (SjD) is a chronic, systemic autoimmune disease that mainly targets saliva- and tear-producing glands. T-cells are a substantial immune cell subset involved in SjD pathogenesis, including break of tolerance toward self, a...
Ayse Altintas,Eser Bulus
Ayse Altintas
Multiple sclerosis (MS) is traditionally considered a chronic immune-mediated disease of the central nervous system. However, increasing evidence suggests substantial clinical, radiological, and immunopathological heterogeneity among indivi...
TRPM7 channel-kinase in immunity: new frontiers of an emerging therapeutic target [0.03%]
瞬时受体电位锚定和转运模体7通道激酶在免疫中的作用：一个新兴治疗靶点的新前沿领域
Birgit Karner-Hoeger,Anna Madlmayr,Susanna Zierler
Birgit Karner-Hoeger
The cation channel and protein kinase transient receptor potential cation channel subfamily M member 7 (TRPM7) has been linked to immune homeostasis, immune cell signaling and differentiation, and inflammatory diseases. Its importance in gu...
Minor salivary gland biopsy in Sjogren's disease: a diagnostic and prognostic tool toward precision medicine [0.03%]
舍格伦综合征的唇腺活检：向精准医疗发展的诊断和预后工具
Loukas Chatzis,Athanasios G Tzioufas
Loukas Chatzis
Minor salivary gland biopsy occupies a distinctive position in the evaluation of Sjögren disease (SjD), offering diagnostic and prognostic insights that are rarely achievable in other systemic autoimmune conditions. It contributes essentia...
Allison Pugel,Xue-Zhong Yu,Yongxia Wu
Allison Pugel
Regulated cell death, including apoptosis, necroptosis, and pyroptosis, as well as cell death arising from disrupted cellular homeostasis, such as ferroptosis and dysregulated autophagy, is implicated in cancer, autoimmunity, and transplant...
Rheumatoid arthritis: revisiting pathogenesis for prevention, stratification, and repair [0.03%]
风湿性关节炎：重新审视发病机制以预防、分层和修复
Frédéric Coutant,Pierre Miossec
Frédéric Coutant
The clinical heterogeneity of rheumatoid arthritis (RA) reflects a series of dynamic immunological imbalances rather than a single dominant mechanism. In this review, we propose that RA progression is best understood as a sequence of three ...
Vivin Kokuhennadige,Elizabeth Aitken,Stephen Rogerson
Vivin Kokuhennadige
Malaria during pregnancy continues to compromise maternal, fetal, and subsequently infant health. This burden has increased in Africa, though it has decreased elsewhere. Here, we provide a concise review of recent findings on malaria in pre...