Implication of epigenetic factors in development and recurrence of psoriasis [0.03%]
表观遗传因素在银屑病发生发展及复发中的作用研究
Jingyi Tang,Erle Dang,Gang Wang
Jingyi Tang
Psoriasis is a chronic autoimmune skin disease characterized by abnormal proliferation and differentiation of keratinocytes, with a complex pathogenesis often linked to environmental and genetic factors. Although many treatments are availab...
Shwetha Maharaj,Christopher Chang
Shwetha Maharaj
Juvenile idiopathic arthritis (JIA) is the most common rheumatological disorder affecting children. It is characterized by chronic synovial inflammation that may lead to permanent joint damage and disability. JIA is an umbrella term for a h...
Paolo Spagnolo,Marc A Judson
Paolo Spagnolo
Sarcoidosis is a systemic granulomatous disease of unknown cause that affects the lungs almost invariably. The clinical course and outcomes of pulmonary sarcoidosis are highly variable, ranging from mild and self-limiting to organ-threateni...
Eliciting or silencing complement activation: strategies for optimizing monoclonal antibodies functions [0.03%]
补体激活的诱导或沉默：优化单克隆抗体功能的策略
Axelle Amen,Nicole Thielens,Chantal Dumestre-Pérard et al.
Axelle Amen et al.
Tuning complement activity is essential to maximize therapeutic efficacy while minimizing off-target effects in monoclonal antibody (mAb) design. Complement-enhancing strategies are primarily applied to mAbs targeting pathogens, infected ce...
Valentin Baverel,Carmen Garrido,Evelyne Kohli
Valentin Baverel
Macrophages and the complement system are fundamental components of innate immunity, emerging early in evolutionary history. The well-established functions of complement in relation to macrophages contribute to both innate and adaptive immu...
Marie-Agnès Dragon Durey,Houcine Hamidi,Luc Darnige
Marie-Agnès Dragon Durey
Antiphospholipid syndrome (APS) is an acquired autoimmune thrombophilia. Complement system, which shares common actors with the coagulation cascade, is nowadays well established to be implicated in APS pathophysiology by different mechanism...
James K Sullivan,Audrey Kwun,Trine N Jørgensen
James K Sullivan
Neuropsychiatric lupus (NPSLE) is believed to manifest in 30-40% of SLE patients, with symptoms spanning from fatigue and anxiety to depression, cognitive impairment, and psychosis. Over the past decades, it has become clear that most anima...
Epigenetic regulation of inflammation dynamics during wound healing: a subtle yet profound shift in histone modifications [0.03%]
伤口愈合过程中炎症动态的表观遗传调节：组蛋白修饰的微妙而深远的变化
Jingyu Xiao,Mengjiao Chen,Yamin Zhang et al.
Jingyu Xiao et al.
Wound healing represents a dynamic process centered on the temporally coordinated inflammatory, proliferative, and remodeling phases. The inflammatory response exhibits a double-edged role: a moderate response is essential for normal healin...
Pier Luigi Meroni,Enrico Capobianco,Francesco Tedesco
Pier Luigi Meroni
Antiphospholipid antibody syndrome (APS) is a vasculopathy with recurrent thrombosis and/or miscarriages mediated by autoantibodies against PL-binding proteins (aPL), mainly beta2glycoprotein I (β2GPI). While clotting is the key in vascula...
Pascal Pedini,Jacques Chiaroni,Christophe Picard
Pascal Pedini
Alloimmunization to blood group antigens is the result of a humoral immune response initiated by exposure to foreign antigens absent from the recipient's red blood cells (RBCs). Interestingly, not all individuals who receive mismatched RBC ...