Current role of ATG in GVHD prevention: optimizing post-transplantation outcomes through combination with PTCY [0.03%]
ATG在GVHD预防中的作用及与PTCY联合应用以优化移植预后的作用
Maria Liga,Dimitrios Tsokanas,Angeliki N Georgopoulou et al.
Maria Liga et al.
Graft versus host disease (GVHD) is one of the major complications of allogeneic hematopoietic cell transplantation (allo-HCT), contributing significantly to post-transplant morbidity and mortality. Anti-thymocyte globulin (ATG) is a widely...
Antonio Tonutti,Saverio D&#x;Amico,Suraj Timilsina et al.
Antonio Tonutti et al.
The complexity and heterogeneity of autoimmune diseases are only partially captured by current analytic tools, even when deep learning techniques are employed to intercept patterns beyond existing dogma. Synthetic data offer a newer paradig...
Autoimmunity beyond antibodies: alternative roles of beta-2-glycoprotein I in and out of antiphospholipid syndrome? [0.03%]
超出抗体的自身免疫：β2-糖蛋白I在和不在抗磷脂综合征中的作用？
Claudia Grossi,Imogen Ih Buckle,Thomas Cr McDonnell
Claudia Grossi
The term autoimmune disease refers to autoantibody-dependent pathophysiological conditions, in which characterising the autoantibodies is essential, as is studying their target(s), the (auto)antigen(s), which represent the other side of the...
Ruiming Zhao,Steve An Goldstein
Ruiming Zhao
Voltage-gated proton channels (Hv1) are key regulators of microglial activation, coupling proton extrusion to reactive oxygen species production, cellular pH homeostasis, and pro-inflammatory signaling. Dysregulated Hv1 activity exacerbates...
Vishal Patel,Antonio Salas,Thomas Grader-Beck
Vishal Patel
Despite major advances in understanding Sjögren's disease (SjD), no approved disease-modifying therapies have been approved. Management remains largely symptomatic with the use of off-label immunomodulators for systemic features. This gap ...
Targeting synovial fibroblast KCa1.1 channels in rheumatoid arthritis [0.03%]
针对类风湿性关节炎滑膜成纤维细胞的KCa1.1通道
Robert Nicholas Elston,Christine Beeton
Robert Nicholas Elston
Fibroblast-like synoviocytes (FLS) play major roles in the pathogenesis of rheumatoid arthritis (RA). Human and rat FLS express the KCa1.1 channel (BK, Maxi-K, Slo1, and KCNMA1) as their major potassium channel at the plasma membrane. Reduc...
Beyond ion flux: the potassium channel KV1.3 and its regulatory function in neutrophils [0.03%]
超越离子流：钾通道KV1.3及其在中性粒细胞中的调控功能
John Ku,Hans-Joachim Anders,Markus Sperandio et al.
John Ku et al.
The voltage-gated potassium channel KV1.3 (KCNA3) is a critical ion channel regulating membrane potential in immune cells, facilitating sustained calcium influx and activating downstream signaling events. Besides its canonical role as an io...
Endothelial dysfunction in APS: advancing pathophysiological understanding to improve management [0.03%]
APS的内皮功能障碍：加深病理生理学认识以改善治疗
Charis Pericleous,Emily Strauss,Deepa J Arachchillage
Charis Pericleous
Endothelial dysfunction (ED) is a hallmark of antiphospholipid syndrome (APS) driven by chronic antiphospholipid antibody (aPL) exposure. Beyond acute thrombotic events, ED contributes to atherosclerosis, vascular remodelling, stenosis and ...
O Julián Velasco-Lancheros,Yeny Acosta-Ampudia,Diana M Monsalve et al.
O Julián Velasco-Lancheros et al.
The reemergence of the mpox virus (MPXV) as a global health threat, with >100 000 cases reported across 115 countries since the WHO's 2022 alert, has intensified research into its pathophysiology. MPXV exists in two main clades with distinc...
Addressing unmet needs in rheumatoid arthritis: the challenge of translating multi-omics into precision therapies [0.03%]
风湿性关节炎未满足需求的治疗：转化多组学以实现精准医疗的挑战
Xin Wu,Keying Chen,Huji Xu
Xin Wu
Rheumatoid arthritis (RA) is a highly heterogeneous chronic systemic inflammatory disease. Approximately 30-40% of patients exhibit an inadequate response to currently available biologic agents and Janus kinase inhibitors. In recent years, ...