Emerging novel therapies for steroid-refractory acute graft-versus-host disease: recent advances and future directions [0.03%]
类固醇难治性急性移植物抗宿主病新疗法的最新进展和未来方向
Yishan Ye,Wenjing Hao,Florent Malard et al.
Yishan Ye et al.
Acute graft-versus-host disease (aGVHD) is a significant complication of allogeneic hematopoietic cell transplantation (allo-HCT), characterized by immune-mediated tissue damage from donor immune cells. Standard treatment of aGVHD involves ...
Carson E Moseley,Joseph J Sabatino Jr,Scott S Zamvil
Carson E Moseley
The role of B cells in central nervous system (CNS) autoimmunity was initially highlighted by successful clinical trials of anti-CD20 monoclonal antibodies in multiple sclerosis (MS). Research in MS as well as in aquaporin 4 (AQP4)-IgG+ neu...
Angelo D&#x;Alessandro,James C Zimring
Angelo D&#x;Alessandro
Purpose of review: This review summarizes recent advances in metabolomics that have enhanced our understanding of transfusion-related immunomodulation (TRIM), highlighting how biochemical changes in stored blood products ...
Kimberly A Thomas,Rachael P Jackman
Kimberly A Thomas
The rising interest in using cold-stored platelets (CSP) for improving outcomes in patients with active bleeding has led to multiple clinical trials with the goal of determining the in vivo hemostatic efficacy of CSP compared to standard-of...
Lewis W Yu,Elaine Y Hsiao
Lewis W Yu
Bidirectional communication between the gut microbiota and neuroimmune system is essential during host-microbiome interactions. Recent research has begun to unravel microbiome-neuroimmune crosstalk and suggest classical neurochemicals as ke...
Fumiya Hirayama,Ayumu Kuroishi,Nobuki Matsuyama et al.
Fumiya Hirayama et al.
Allergic transfusion reactions (ATRs) are among the most common adverse nonhemolytic transfusion reactions. However, since ATR is diagnosed based only on clinical observations, contrary to other allergic diseases, the causal relationship be...
Checkpoint agonists - immunoregulatory role and its implications in the treatment of psoriasis and psoriatic arthritis [0.03%]
检查点激动剂的免疫调节作用及其在银屑病和银屑病关节炎治疗中的意义
Angel Ray Baroz,Debra K Lee,Natalia Maverakis Ramirez et al.
Angel Ray Baroz et al.
Psoriasis and psoriatic arthritis are chronic autoimmune diseases characterized by dysregulated immune responses, particularly involving Th17 cells. Immune checkpoint molecules such as programmed death-1 (PD-1) and its ligands (PD-L1/PD-L2)...
Giannini Olivier,Elzi Luigia
Giannini Olivier
Patients with chronic kidney disease (CKD), especially those with end-stage kidney disease on dialysis or kidney transplant recipients (KTRs), are highly susceptible to infections, including the novel severe acute respiratory syndrome coron...
Can we cure lupus? [0.03%]
狼疮能够被治愈吗？
Tessa L Clement,Philip L Cohen
Tessa L Clement
A general understanding of the mechanisms leading to the development of systemic lupus has emerged over recent years, yet treatment of the illness remains largely empiric and unsatisfactory. Targeted therapy with monoclonal antibodies direc...
B cell-targeted therapies in autoimmune skin disease: current advances and challenges [0.03%]
自身免疫性皮肤病中的B细胞靶向治疗：目前的进展与挑战
Zhi Hu,Ming Zhao
Zhi Hu
Autoimmune skin diseases (AISDs) constitute a group of skin disorders driven by B cell-mediated autoimmunity or dysregulation of other immune cell populations. AISD can be further divided into systemic autoimmune disease with skin involveme...