Advances in treatment of psoriatic arthritis: current guidelines and emerging therapies [0.03%]
银屑病关节炎的治疗进展：现行指南和新兴疗法
Ashley M Feldkamp,Siba P Raychaudhuri
Ashley M Feldkamp
Psoriatic arthritis (PsA) is a multifaceted autoimmune condition that affects the peripheral and axial joints, entheses, skin, and nails. The management of PsA relies on prompt diagnosis and early initiation of effective treatment to minimi...
Protective or pathogenic? Tuft cells shape divergent immune outcomes in helminth and viral infections [0.03%]
卫护还是致病？杯状tuft细胞在寄生虫和病毒感染中塑造不同的免疫结局
Miles Dw Tyner,Michael R Howitt
Miles Dw Tyner
Tuft cells are epithelial sentinels that monitor the luminal environment at barrier sites throughout the body. Their function as crucial initiators of type 2 immunity against helminths and protists in the intestine emerged nearly a decade a...
Fanny Saidoune,Ahmad Yatim,Jeremy Di Domizio et al.
Fanny Saidoune et al.
SARS-CoV-2 infection and vaccination are associated with a broad range of skin manifestations, including chilblains, urticaria, morbilliform and papulovesicular rashes, purpuric-necrotic lesions, and autoimmune flares. These patterns reflec...
Approved and emerging therapies for glucocorticoid-refractory chronic graft-versus-host disease [0.03%]
糖皮质激素难治性慢性移植物抗宿主病的获批和新兴疗法
Xinwen Zhang,Yuxin Ren,Ruihao Huang et al.
Xinwen Zhang et al.
Glucocorticoid-refractory chronic graft-versus-host disease (glucocorticoid-refractory cGVHD) remains a major barrier to long-term survival and quality of life following allogeneic hematopoietic stem cell transplantation (allo-HSCT), affect...
Complement in systemic lupus erythematosus across time and space: from tolerance to tissue injury and from extracellular to intracellular functions [0.03%]
时空中的补体在系统性红斑狼疮中：从耐受至组织损伤以及从细胞外至细胞内功能
Giovanna Clavarino,Jeanne Vigne,Marie-Sophie Meuleman et al.
Giovanna Clavarino et al.
The complement system plays a paradoxical role in systemic lupus erythematosus physiopathology, acting both as a protective mechanism and as a driver of tissue injury, depending on disease stage. Neutrophil extracellular traps (NETs) furthe...
Federica Defendi,Axelle Amen,Giovanna Clavarino et al.
Federica Defendi et al.
C1 Inhibitor (C1INH) is a crucial regulator of multiple plasmatic pathways, including complement, coagulation, kallikrein-kinin systems, and fibrinolysis. C1INH deficiency results in the downstream overproduction of the vasoactive peptide b...
Human inborn errors of type I interferon-independent intrinsic immunity in nonleukocytic cells [0.03%]
非白细胞固有免疫中I型干扰素独立的先天性缺陷病人类病例
Shen-Ying Zhang,Jean-Laurent Casanova,András N Spaan
Shen-Ying Zhang
'Intrinsic immunity' is often used to refer to mechanisms of host defense operating in nonleukocytic cells. This term can refer to the intrinsic capacity of an individual cell to fend off invading microbes without help from other cells or o...
Karol Bączek,Wojciech J Piotrowski,Francesco Bonella
Karol Bączek
Purpose of review: Diagnosing sarcoidosis remains challenging. Histology findings and a variable clinical presentation can mimic other infectious, malignant, and autoimmune diseases. This review synthesizes current eviden...
Zihan Ma,Richard W Pierce,Carrie L Lucas et al.
Zihan Ma et al.
Endothelial cells (ECs) integrate immune and vascular functions to promote host defense against pathogens. While previously studied as forming passive flow conduits, ECs are now recognized as active contributors to maladaptive inflammation....
Transfusion-related acute lung injury: experimental models to study pathogenesis and therapeutic strategies [0.03%]
输血相关性急性肺损伤：探讨其发病机制和治疗策略的实验模型
Farahnaz Rayatdoost,Rick Kapur
Farahnaz Rayatdoost
Transfusion-related acute lung injury (TRALI) is a life-threatening complication of blood transfusion, with mortality rates exceeding 40% in critically ill patients. Despite its clinical severity, TRALI pathogenesis remains unclear, leaving...