Deciphering and harnessing gut microbiota-associated immune regulation in acute graft-versus-host disease [0.03%]
解读并利用肠道微生物群相关免疫调节在急性移植物抗宿主病中的作用
Emmanuelle Godefroy,Frédéric Altare
Emmanuelle Godefroy
Allogeneic hematopoietic stem cell transplantation represents a curative treatment of choice for numerous severe hematological malignancies. While donor-derived transplanted T cells can limit disease relapse (GvT/GvL effect), they also indu...
Optimizing post-transplantation cell therapies to enhance graft-versus-leukemia effects in hematological malignancies [0.03%]
优化移植后细胞治疗以增强异体白血病效应来治疗血液系统恶性肿瘤
Simone A Minnie,Melissa M Berrien-Elliott,Melody Smith et al.
Simone A Minnie et al.
Allogeneic hematopoietic cell transplantation (HCT) can cure patients with high-risk hematologic malignancies. Donor T and natural killer (NK) cells contribute to graft-versus-leukemia (GVL) effects that provide relapse protection. Post-HCT...
Layers of defense: protection from respiratory viruses by epithelial-intrinsic immunity [0.03%]
呼吸道病毒的上皮固有免疫防御机制
Ellen F Foxman
Ellen F Foxman
A central challenge in defending mucosal barriers is protecting against pathogens while also limiting excessive inflammation. Respiratory viruses are a prime example - respiratory viruses present a threat to their target cells, the epitheli...
The epidermal immune microenvironment plays a central role in the pathogenesis of psoriasis [0.03%]
表皮免疫微环境在银屑病发病机制中起核心作用
Yuan Zhou,Xiao-Yong Man
Yuan Zhou
Psoriasis is a chronic immune-mediated skin disease whose inflammation can affect other systems and lead to various comorbidities. As a model inflammatory skin disease, while advances in mechanistic insights and targeted therapies have impr...
When granulomatous inflammation becomes visible: insights into cutaneous sarcoidosis [0.03%]
当肉芽肿性炎症变得可见时：皮肤结节病的洞见
Mariam Alam,Avrom S Caplan,Misha Rosenbach
Mariam Alam
Cutaneous involvement of sarcoidosis can provide important insights into the presence and prognosis of systemic involvement. Recent insights into the underlying pathophysiology of sarcoidosis have allowed for more targeted therapy, includin...
Anne Godat,Dimitrios Chistoforidis,Thomas Greuter
Anne Godat
Inflammatory bowel disease (IBD) represents a chronic inflammation of the gastrointestinal tract that arises from a complex interplay between a dysregulated immune response in genetically predisposed individuals. IBD can further be classifi...
The outcome of severe MIS-C managed at the Italian epicenter of the SARS-CoV-2 epidemic: a follow-up study of 50 consecutive patients [0.03%]
意大利新冠疫情重灾区严重MIS-C预后：50例连续患者的随访研究
Lucio Verdoni,Angelo Mazza,Laura Martelli et al.
Lucio Verdoni et al.
Background: During the SARS-CoV-2 pandemic, we described a peak of a Kawasaki-like disease in children, later renamed multisystem inflammatory syndrome in children (MIS-C). We report the long-term outcomes of MIS-C patien...
Martin Petrek,Natalia V Rivera
Martin Petrek
Sarcoidosis is a complex, polygenic, and multifactorial disease characterized by granulomas in affected organs, which are the hallmark of the condition. Genetic susceptibility, environmental influences, and lifestyle factors play key roles ...
Post-transplant cyclophosphamide for graft-versus-host disease prophylaxis: current status and optimization strategies [0.03%]
移植后环磷酰胺在预防移植物抗宿主病中的应用现状及优化策略
Shigeo Fuji,Akihiro Ohmoto
Shigeo Fuji
Since its first application in HLA-haploidentical settings, post-transplant cyclophosphamide (PTCy) has become a standard for graft-versus-host disease (GVHD) prophylaxis, with its use expanding to matched and mismatched hematopoietic cell ...
Microglia and myeloperoxidase in neuroinflammatory and neurodegenerative diseases [0.03%]
小胶质细胞和髓过氧化物酶在神经炎症和神经退行性疾病中的作用
Lorenzo Del Moro,Enrico Brunetta,M Eric Gershwin et al.
Lorenzo Del Moro et al.
The dogma of an impenetrable blood-brain barrier (BBB) has given way to the view that resident immune cells within the central nervous system respond to a variety of blood-borne soluble factors, particularly cytokines, and play an important...