New learnings from the molecular pathology of the synovial tissue in rheumatoid arthritis: from pathogenesis to therapeutic targeting toward precision medicine [0.03%]
类风湿关节炎滑膜组织分子病理的新认识：从发病机制到治疗靶点的精准医学研究方向
Yongjing Cheng,Ketian Li,Muyun Ma et al.
Yongjing Cheng et al.
Despite the success of targeted therapies in rheumatoid arthritis, the lack of predictive biomarkers of response leads to an empirical treatment approach, often delaying effective intervention due to non-response to the initially selected i...
Dan Liu,Jiayao Huo
Dan Liu
The spleen is a central immune organ that surveys blood-borne pathogens and coordinates systemic immune responses. Within this organ, conventional dendritic cell (cDC) subsets occupy blood-exposed niches that enable efficient antigen captur...
Palak J Trivedi,Gideon M Hirschfield,M Eric Gershwin
Palak J Trivedi
Primary biliary cholangitis (PBC) is a chronic immune-mediated liver disease characterized by progressive destruction of the intrahepatic bile ducts, leading to cholestasis, fibrosis, and eventual cirrhosis. Despite advances in understandin...
Won't you be my neighbor? Control of the immune response by stromal and immune cell microenvironments within the lymph node [0.03%]
邻间质细胞和免疫细胞微环境如何调控淋巴结内的免疫反应
Andrew G Harrison,Ivan Zanoni
Andrew G Harrison
Efficacious immune responses require the coordinated encounter of rare antigen-specific adaptive lymphocytes with their cognate innate antigen-presenting cells (APCs) in space and time. This spatiotemporal problem of immunity is solved by s...
The role of different aPL subpopulations in the lupus anticoagulant phenomenon [0.03%]
不同aPL亚群在狼疮抗凝物现象中的作用
Deepa J Arachchillage,Maria Efthymiou,Hannah Cohen
Deepa J Arachchillage
The lupus anticoagulant (LA) phenomenon represents a paradoxical prothrombotic state characterised by inhibition of phospholipid-dependent coagulation assays in vitro, despite a strong association with thrombosis and pregnancy morbidity in ...
Sumatha Channapatna Suresh,Richard Furie,Sonali Narain
Sumatha Channapatna Suresh
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by fluctuating multisystem involvement, relapsing-remitting activity, and substantial risk of irreversible organ damage. Standardized disease activity in...
Optimal donor selection for transplant to reduce GVHD risk and augment graft-versus-malignancy efficacy [0.03%]
优化供者选择以降低移植后移植物抗宿主病风险和增强移植物抗白血病效应
Brian C Shaffer,Bronwen E Shaw
Brian C Shaffer
Allogeneic hematopoietic cell transplantation (alloHCT) is curative for many patients with high-risk, hematologic malignancies. AlloHCT depends on a graft versus malignancy (GVM) phenomenon, whereby donor-derived immune cells recognize and ...
From sensing to shaping: microglial responses in the pathogenesis of viral encephalitis [0.03%]
从感知到塑造：微胶质细胞反应在病毒性脑炎发病机制中的作用
Kamalika Roy,Akasmika Priyadarsani,Anirban Basu
Kamalika Roy
Viral encephalitis (VE) is a universal menace accounting for severe morbidity and mortality among the affected individuals. VE is the cerebral inflammation triggered by viral infections. In the central nervous system, microglia are the fron...
Kenneth Stauderman,Sudarshan Hebbar,Stefan Feske
Kenneth Stauderman
Ca²⁺ release-activated Ca²⁺ (CRAC) channels facilitate store-operated Ca²⁺ entry in both immune and nonimmune cells. They are crucial for the function of many immune cell types and strongly associated with the pathophysiology of immun...
Understanding antiphospholipid syndrome clinical phenotypes with the guidance of antiphospholipid antibody-related pathogenic mechanisms [0.03%]
抗磷脂抗体相关致病机制指导下理解抗磷脂综合征临床表型
Ecem Sevim,Zeynep B Erton,Doruk Erkan
Ecem Sevim
Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by thrombosis, microvascular disease, pregnancy morbidity, or non-thrombotic manifestations in patients with antiphospholipid antibodies. The mechanistic differ...