Decoding the complexity of intestinal immunity with spatial transcriptomics [0.03%]
空间转录组学解析肠道免疫的复杂性
Martín Suárez-Álvarez,María A Ulloa,Eduardo J Villablanca
Martín Suárez-Álvarez
The intestine integrates nutrient digestion and absorption with immune surveillance, being continuously challenged by dietary antigens, commensal microbiota, and pathogens. Its highly regionalized structure requires the immune system to bal...
Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection [0.03%]
抗磷脂抗体固相测定的免疫学方面需重新考虑
Maria Orietta Borghi,Elena Raschi,Caterina Bodio et al.
Maria Orietta Borghi et al.
Solid‑phase assays for the detection of antiphospholipid antibodies (aPL) are central to the laboratory evaluation of antiphospholipid syndrome (APS). Growing insights into the molecular immunology underlying these assays challenge traditi...
Engineering human synovial organoids as predictive ecosystems for disease modeling and therapeutic response in rheumatology [0.03%]
工程人类滑膜器官样组织作为风湿病疾病建模和治疗反应的预测生态系统
Zixie Liang,Jiapeng Zhang,Zewen Wu et al.
Zixie Liang et al.
The synovium is a critical site for the initiation and persistence of inflammatory joint diseases, including rheumatoid arthritis (RA), osteoarthritis (OA), and gout. Conventional 2D cultures and animal models fail to recapitulate the multi...
Amy K Rivers,Camila Migues Ramirez,Simon J Cleary
Amy K Rivers
Lymphatic vessels maintain fluid balance and immune protection by transporting fluid, solutes and cells from tissue interstitial spaces to lymph nodes. The lymphatic endothelial cells that form lymphatics differentiate throughout the body t...
Raynaud's phenomenon: a vascular or an autoimmune-mediated disorder? Facts and fancy [0.03%]
瑞叶氏现象：血管问题还是自身免疫性疾患？事实与推测
Haralampos M Moutsopoulos,Ilir I Cinoku,Clio P Mavragani
Haralampos M Moutsopoulos
Raynaud's phenomenon (RP) is a common vasospastic disorder characterized by transient digital ischemia triggered by cold exposure or emotional stress. It is classified as primary or secondary, the latter often associated with autoimmune con...
Hantavirus on the rise: clinical, virological, immunological, and public health perspectives [0.03%]
汉坦病毒疫情上升：临床、病毒学、免疫学和公共卫生角度的分析
Arpan Acharya,Swathi P Murakonda,Debapriya Sutar et al.
Arpan Acharya et al.
Hantaviruses are enveloped, negative-sense RNA viruses. Rodents serve as natural reservoirs, and spillover into humans causes hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. While transmission typically occurs by in...
Spatial omics of immunity: Mapping cellular landscapes in tissue microenvironments [0.03%]
免疫空间组学：组织微环境中细胞景观的定位映射
Ji-Eun See,Yuitian Liu,Jasmine Plummer
Ji-Eun See
The tumor microenvironment (TME) is composed of diverse heterogeneous components and plays a crucial role in immune cell infiltration, immune evasion, and dynamic interactions between tumor cells and the immune system. A precise understandi...
Novel mechanisms linking platelet activation to antiphospholipid syndrome [0.03%]
新的连接血小板活化与抗磷脂综合征的机制
Marina Camera,Elena Tremoli,Paola A Lonati et al.
Marina Camera et al.
Antiphospholipid syndrome (APS) is a thromboinflammatory disorder in which antiphospholipid antibodies (aPL), particularly anti-β2GPI, initiate a complex, graded platelet activation that integrates immune signaling with coagulation. Clinic...
When the lung is at risk: diagnosis, manifestations, and complications of pulmonary sarcoidosis [0.03%]
肺结节病的诊断、临床表现和并发症：当心您的肺！
Zehra Dhanani,Adriane Dm Vorselaars,Rohit Gupta et al.
Zehra Dhanani et al.
Sarcoidosis is a heterogeneous granulomatous disease of unknown origin; a subset of patients develops an advanced pulmonary disease phenotype, marked by progressive pulmonary fibrosis, airway involvement, and sarcoidosis-associated pulmonar...
Biochemical and cytokine environment in skeletally immature patients after traumatic knee injuries [0.03%]
骨骼未发育完全的患者膝关节创伤性损伤后的生化与细胞因子环境特征
Marco Crippa,Ramona Meanti,Giulia Beltrame et al.
Marco Crippa et al.
Traumatic knee injuries in skeletally immature patients occur in a unique biological context shaped by growth, high tissue turnover, and distinct immune-repair dynamics. Beyond structural damage, acute post-traumatic changes in synovial flu...