Salivary gland organoids and the future of modeling autoimmune epithelitis in Sjögren's disease [0.03%]
唾液腺类器官和Sjögren综合征自身免疫性上皮炎建模的未来
Ting Yang,Negaar Goudarzi,Frans G M Kroese et al.
Ting Yang et al.
Sjögren's disease (SjD) is a systemic autoimmune disorder characterized by a striking tropism for epithelial tissues, particularly the salivary and lacrimal glands. Lack of function of the salivary glands (SGs) leads to a panoply of sympto...
Revisiting tryptophan metabolism in cancer: complexity, context, and spatial heterogeneity [0.03%]
revisit癌症中的色氨酸代谢：复杂性、环境和空间异质性
Teng Teng Xu,Camille Guyot,Peter J Murray
Teng Teng Xu
Tryptophan (TRP) metabolism has long been associated with cancer immunity, primarily through the kynurenine pathway mediated by indoleamine-2,3-dioxygenase 1 (IDO1) and tryptophan-2,3-dioxygenase (TDO2). Both enzymes can deplete TRP within ...
Patompong Ungprasert,Brandon P Moss
Patompong Ungprasert
Clinically overt granulomatous involvement of the nervous system, or neurosarcoidosis, occurs in up to 5% of patients with sarcoidosis. Diagnosing neurosarcoidosis is often challenging due to its highly heterogeneous and frequently nonspeci...
Sylvia Raftopoulou,Athanasios-Dimitrios Bakasis,Clio P Mavragani
Sylvia Raftopoulou
Sjögren's disease (SjD) is a systemic autoimmune disorder marked by chronic immune activation, with a central role attributed to the interferon (IFN) system. The so-called 'IFN signature' at both tissue and peripheral levels has long been ...
Is psoriatic arthritis a dissemination of cutaneous psoriatic TRM cells? Role of tissue-resident memory T cells (TRM) in psoriatic disease [0.03%]
银屑病关节炎是皮肤部位的银屑病TRM细胞播散吗？组织驻留记忆T细胞（TRM）在银屑病性疾病中的作用
Siba P Raychaudhuri,Smriti K Raychaudhuri
Siba P Raychaudhuri
Tissue resident memory T cells (TRM) cells are a recently defined subtype of nonrecirculating memory T cells with longevity and protective functions in peripheral tissues. The discovery of T cells resident in diverse tissues has altered our...
Sushmitha Meghashyam,Fatema J Serajee,Aviraag V Prakash et al.
Sushmitha Meghashyam et al.
Primary central nervous system vasculitis, also known as primary angiitis of CNS (PACNS), is a rare and heterogeneous inflammatory disorder of blood vessels restricted to the central nervous system. The most common presenting symptoms are h...
Toward indole postbiotics precision therapy via AI-powered drug delivery technologies [0.03%]
基于人工智能的药物递送技术驱动的吲哚类后生物精确诊疗
Puccetti Matteo,Pariano Marilena,Wojtylo Paulina Anna et al.
Puccetti Matteo et al.
Recent advancements in microbiome research have revealed the restorative capacities of postbiotics, including indole and its derivatives generated via bacterial tryptophan metabolism. Widespread in prokaryotic and eukaryotic communities, in...
The power of genetics in decoding Sjögren's disease: current status and future development [0.03%]
遗传学在解码自身免疫性疾病斯乔格伦综合征中的作用：现状与未来展望
Marcin Radziszewski,Kandice L Tessneer,Christopher J Lessard
Marcin Radziszewski
Sjögren's disease (SjD) is the second most common systemic autoimmune disease in the United States. SjD patients are predominantly women 30-50 years of age and exhibit heterogeneous clinical manifestations, including symptoms of extensive ...
Nicolle Sweeney,Yemil Atisha-Fregoso,Rita Pozovskiy et al.
Nicolle Sweeney et al.
Autoimmune diseases have, until recently, been treated with relatively broad immunosuppressive regimens. Newer, more focused monoclonal antibody therapies directed to specific targets, for example, anti-TNF or anti-B cell therapies, can pro...
Jonas Lowack,Alexander Pj Vlaar,Robert B Klanderman et al.
Jonas Lowack et al.
Transfusion-associated circulatory overload (TACO) and transfusion-related acute lung injury (TRALI) are leading causes of transfusion-related morbidity and mortality. Despite distinct diagnostic criteria, both syndromes present similarly w...