Humphrey Lotana,Tristan White,Wonder Puryear Drake
Humphrey Lotana
Sarcoidosis is a multisystem inflammatory disorder characterized by noncaseating granulomas in various organs, predominantly affecting the lungs and lymphatic system. Although the etiology of sarcoidosis remains unknown, it is believed to r...
Markers predicting lymphoma development in Sjögren disease: current status and future perspectives [0.03%]
Sjögren病淋巴瘤发生的预测标志物：现状及未来展望
Konstantinos N Panagiotopoulos,Athanasios G Tzioufas,Andreas V Goules
Konstantinos N Panagiotopoulos
We aim to present recent advancements in predictive markers for lymphomagenesis in SjD, concisely organize existing knowledge, and identify corresponding unmet needs and future perspectives. First, we briefly describe the mechanisms of lymp...
Nico De Crem,Wim Alfons Wuyts
Nico De Crem
Sarcoidosis is a complex and heterogenous disease of which the diagnosis is based on clinical and radiological findings, histopathology showing non-caseating granulomas, and exclusion of other granulomatous diseases. Several tools are well ...
Mapping the B-cell axis in Sjögren's disease: repertoire, microenvironment, and potential routes to precision treatment [0.03%]
Sjögren综合征的B细胞轴图谱：克隆型、微环境及精准治疗的新途径
Loukas Chatzis,Dimitris Anastasios Palamidas,Thomas Dörner
Loukas Chatzis
Sjögren's disease (SjD) is a chronic autoimmune disorder in which sustained B-cell activation drives glandular injury and systemic complications. Epithelial stress and interferon tone amplify B-cell activating factor (BAFF)-dependent survi...
Francesco Siracusa,Andres Machicote,Samuel Huber et al.
Francesco Siracusa et al.
The intestinal microbiota transforms dietary components into bioactive metabolites that profoundly influence mucosal and systemic immunity. Short-chain fatty acids, secondary bile acids and tryptophan-derived indoles are among the most stud...
Carine El Sissy,Jérémie Rosain,Mathilde Puel et al.
Carine El Sissy et al.
The complement system is a central component of innate immunity, mediating opsonization, chemotaxis, cytolysis, and shaping adaptive responses. Deficiencies in complement proteins, whether inherited or acquired, predispose to severe infecti...
The role of linked recognition and B cell precursor frequency in alloimmunization to transfused RBCs [0.03%]
输血RBCs的联锁识别和B细胞前体频率在异免疫中的作用
Elizabeth L Frost,Arijita Jash,Angelo D&#x;Alessandro et al.
Elizabeth L Frost et al.
Despite multiple alloantigenic differences in every allotransfusion, only 3-6% of transfusion recipients develop a detectable alloantibody even with multiple transfusions. Moreover, patients typically become alloimmunized only to some of th...
Mehmet Ali Hoskan,Vanessa Sperandio
Mehmet Ali Hoskan
Indole is an abundant metabolite in the mammalian gut. Both mammals and microorganisms sense it. Indole is a signal used to communicate and gauge the gut environment. Indole is produced by bacteria that encode the tryptophanase enzyme. Howe...
Roberta E Ledda,Camilla Roberti,Nicola Sverzellati
Roberta E Ledda
Sarcoidosis is a multisystem inflammatory disorder characterized by noncaseating epithelioid granulomata, most commonly involving the lungs and thoracic lymph nodes. Although definitive diagnosis relies on tissue biopsy, characteristic find...
Meichang Peng,Haitao Sun
Meichang Peng
The microbiota-gut-brain axis (MGBA) has been recognized as an important communication network between the gut and the brain. This network operates through immune, neural, and endocrine pathways, wherein microbiota-derived metabolites act a...