José López-Bucio,Kirán Rubí Jiménez-Vázquez,Esperanza Martínez-Romero
José López-Bucio
The production of indole-3-acetic acid (IAA, auxin) is universal in microbes and plants, and contributes to human wellness, acting as an anticancer and anti-inflammatory agent. This review highlights the ubiquity of IAA production by microb...
Cameron S Bader,Everett H Meyer,Robert S Negrin
Cameron S Bader
Regulatory T cells (Tregs) are a rare subset of T cells that are potent regulators of the immune system. As a result, the use of Tregs to prevent undesired immune activation and to re-establish immune balance is an attractive cellular thera...
Anna Duval,Julia Roquigny,Véronique Frémeaux-Bacchi
Anna Duval
Complement inhibition has revolutionized the management of hemolytic diseases by targeting the underlying drivers of red blood cell destruction in disorders such as paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, an...
Haiyu Wang,Daan J van den Brink,Balthasar A Heesters et al.
Haiyu Wang et al.
Excessive complement activation represents a major pathogenic mechanism for a range of serious human diseases. Complement-inhibitory therapeutics have been approved for a number of rare and ultra-rare conditions, with several others in clin...
Manuel Rojas,Yeny Acosta-Ampudia,Diana M Monsalve et al.
Manuel Rojas et al.
Infectious agents are potential triggers for autoimmune diseases (ADs) in susceptible individuals, with infection being a key factor in initiating autoimmunity. Epidemiological and experimental evidence suggests molecular mimicry as a plaus...
Regina M Antonetti,Manan Shah,Noah S Butler
Regina M Antonetti
Malaria is a life-threatening disease affecting more than 200 million people worldwide. CD4 T helper 1 (Th1) and T follicular helper (Tfh) cells are critical for stimulating phagocyte activation and humoral immunity, yet sterilizing, protec...
Yoshiaki Matsushima,Samuel T Hwang,Scott I Simon
Yoshiaki Matsushima
While T cells play a prominent role, polymorphonuclear neutrophils (PMN) are also significant players in the pathogenesis of psoriasis. This review details the mechanobiology of PMN in the amplification of skin inflammation, a process often...
Brian Imbiakha,Hana Janova,Michael S Diamond
Brian Imbiakha
Neurotropic viruses represent a public health challenge due to their ability to cause severe neurological conditions, including meningitis, encephalitis, and paralysis. Although many studies have investigated the immune responses to viral i...
Niamh Logan,Jessica Raja,Elisabetta A Renzoni
Niamh Logan
Sarcoidosis is a heterogeneous condition, with some presentations associated with spontaneous remission and favourable outcome without treatment. Other presentations, including small fibre neuropathy, arthropathy and sarcoid-associated fati...
Deciphering and harnessing gut microbiota-associated immune regulation in acute graft-versus-host disease [0.03%]
解读并利用肠道微生物群相关免疫调节在急性移植物抗宿主病中的作用
Emmanuelle Godefroy,Frédéric Altare
Emmanuelle Godefroy
Allogeneic hematopoietic stem cell transplantation represents a curative treatment of choice for numerous severe hematological malignancies. While donor-derived transplanted T cells can limit disease relapse (GvT/GvL effect), they also indu...