Interplay of innate and adaptive immunity in metal-induced hypersensitivity [0.03%]
金属诱导的变态反应中先天免疫和适应性免疫的相互作用
Amy S McKee,Andrew P Fontenot
Amy S McKee
Metal-induced hypersensitivity is driven by T cell sensitization to metal ions. Recent advances in our understanding of the complex interactions between innate and adaptive immunity have expanded our knowledge of the pathogenesis of these d...
Epigenetic modifications: mechanisms of disease and biomarkers of food allergy [0.03%]
表观遗传修饰：食物过敏疾病的机制及生物标志物
David J Martino,Richard Saffery,Katrina J Allen et al.
David J Martino et al.
The rise in IgE-mediated food allergy in recent times is the likely result of gene-environment interactions mediated via epigenetic pathways. As epigenetic modifications, including DNA methylation, are at the interface between the environme...
Beatriz Cabanillas,Natalija Novak
Beatriz Cabanillas
Filaggrin has a key structural and functional role in the epidermis with important impact on the homeostasis of the skin. Inherited or acquired filaggrin deficiency has been described to essentially contribute to the pathogenesis of atopic ...
Christopher C Norbury,Laurence C Eisenlohr
Christopher C Norbury
Michal Bassani-Sternberg,George Coukos
Michal Bassani-Sternberg
The antigenic landscape of tumors is distinct from healthy cells and has been the rationale behind a variety of vaccination trials. Typically the target tumor-associated antigens have been of self origin and have rarely induced effective an...
Giving CD4+ T cells the slip: viral interference with MHC class II-restricted antigen processing and presentation [0.03%]
逃避CD4+T细胞的监控：病毒对MHCⅡ类限制性抗原加工和呈递的干扰作用
Katherine S Forsyth,Laurence C Eisenlohr
Katherine S Forsyth
Activation of CD4+ T cells through interactions with peptides bound to Major Histocompatibility Complex Class II (MHC-II) molecules is a crucial step in clearance of most pathogens. Consequently, many viruses have evolved ways of blocking t...
Sébastien Apcher,Rodrigo Prado Martins,Robin Fåhraeus
Sébastien Apcher
The source of peptides that enter the major histocompatibility class I (MHCI) pathway has been intensively debated over the last two decades. The initial assumption that peptides are derived from degradation of full length proteins was chal...
Elodie Mohr,Claire-Anne Siegrist
Elodie Mohr
The challenge for any vaccine design is to elicit protective humoral and/or cytotoxic immunity against life threatening pathogens while remaining innocuous. Neonatal vaccinology faces additional challenges linked to intrinsic peculiarities ...
Christopher C Norbury
Christopher C Norbury
Cross presentation is the process of production of peptide-MHC Class I complexes by cells in which the antigen that is the source of peptide is not translated. The majority of recent studies have described many facets of the classical TAP-d...
Editorial overview: Special section: New concepts in antibody therapeutics: What's in store for antibody therapy? [0.03%]
特约综述: 抗体治疗的新概念: 抗体治疗的未来方向是什么？
Janine Schuurman,Paul Whi Parren
Janine Schuurman