HLA-B27 as a potential target for the cure of axial spondyloarthritis [0.03%]
HLA-B27作为轴向脊柱关节炎治疗靶点的潜力
Carlo Cannistrà,Suraj Timilsina,Merrill Eric Gershwin et al.
Carlo Cannistrà et al.
Axial spondyloarthritis (axSpA) manifests with inflammatory back pain and is diagnosed predominantly in subjects carrying the human leucocyte antigen (HLA)-B27 allele. While not diagnostic for the disease or a predictive biomarker in the ge...
Metabolic regulation of the immune cell in psoriasis: mechanisms and interventions [0.03%]
银屑病中免疫细胞的代谢调控：机制及干预措施
Dan Hong,Hui Xiong,Siyao Lu et al.
Dan Hong et al.
Psoriasis is increasingly recognized as a metabolically regulated inflammatory skin disease. Aberrant glycolysis, oxidative phosphorylation, lipid metabolism, and amino acid metabolism reshape T cell, dendritic cell, macrophage, and neutrop...
Maria Serena Longhi,Lina Zhang,Giorgina Mieli-Vergani et al.
Maria Serena Longhi et al.
Autoimmune hepatitis (AIH) is an organ-specific autoimmune disorder mainly affecting females and characterized by seropositivity for autoantibodies, hypergammaglobulinemia, and histological evidence of interface hepatitis. Liver damage in A...
Mapping economic outcomes: how biosimilars enhance access to health systems in Latin America and the Caribbean [0.03%]
生物类似药在拉丁美洲和加勒比地区的经济效果分析：提高医疗体系可及性
María Herrán,Juan-Manuel Anaya
María Herrán
Biological therapy has revolutionized the treatment landscape of complex and chronic conditions, including autoimmune diseases and cancer. However, their high costs have significantly limited patient access, particularly in low- and middle-...
Moving beyond the Janus kinase signaling kinases in the pathogenesis and treatment of psoriasis and psoriatic arthritis [0.03%]
超越jak在银屑病和银屑病关节炎发病机制及治疗中的作用
Smriti K Raychaudhuri,Disha Chakraborty,Christopher L Leonardini et al.
Smriti K Raychaudhuri et al.
Psoriatic disease encompasses psoriasis and psoriatic arthritis. It is a chronic, progressive condition and leads to irreversible joint destruction. Conventional treatments used are disease-modifying antirheumatic drugs and biologics. Janus...
Concept of dual immune inhibitors for the treatment of drug-resistant psoriatic disease [0.03%]
用于治疗耐药性银屑病的双重免疫抑制剂概念研究
Disha Chakraborty,Siba P Raychaudhuri
Disha Chakraborty
Biologic therapies have significantly improved the management of immune-mediated conditions like psoriatic disease, enhancing the quality of life of patients. However, monotherapy is often insufficient, especially in cases of relapse, conco...
The role of epigenetic modifications in systemic autoinflammatory diseases [0.03%]
表观遗传修饰在系统性自身炎症性疾病中的作用
Kader Cetin Gedik,Desiré Casares-Marfil,Erkan Demirkaya et al.
Kader Cetin Gedik et al.
Autoinflammatory diseases are a group of immune dysregulation disorders, with genetic mutations identified in approximately 50% of patients. However, patients with known pathogenic mutations may display a broad range of phenotypic diversity...
Development and consequences of red blood cell autoantibodies: warm autoimmune hemolytic anemia [0.03%]
红细胞自身抗体的产生及后果：温性自身免疫性溶血性贫血
Flavia Dei Zotti,Krystalyn E Hudson
Flavia Dei Zotti
Autoimmune hemolytic anemia (AIHA) is a rare disorder caused by loss of tolerance to red blood cell (RBC) antigens, leading to their destruction by autoantibodies. AIHA can occur as a primary condition or secondary to infections, malignanci...
Inflammation induced by lipid mediators and protein from transfusion products [0.03%]
输血制品中的脂质介质和蛋白质引起的炎症反应
Chloe Heranney,Mailys Portier,Fabrice Cognasse et al.
Chloe Heranney et al.
Purpose of the review: Platelet and red blood cell (RBC) transfusions, whether used as prophylactic measures or therapeutic interventions, are critical for saving lives. However, the composition of platelet and RBC concen...
Pathogenic mechanisms of autoantibodies in neurological autoimmune diseases [0.03%]
自身免疫性疾病中自身抗体的致病机制
Siyuan Fan,Harald Prüss
Siyuan Fan
Over recent decades, the significance of autoantibodies has been increasingly recognized in neurological diseases. Breakthroughs, such as the identification of pathogenic autoantibodies targeting aquaporin-4 in central nervous system demyel...