Shubham Khetan,Martha L Bulyk
Shubham Khetan
Transcription factor (TF) paralogs provide unique insights into how DNA-binding specificity evolves and diversifies. While paralogous TFs share conserved, highly similar DNA-binding domains, they achieve distinct regulatory functions throug...
Allosteric binding cooperativity in kinases signaling, signalopathies, and drug development [0.03%]
蛋白激酶信号传导、信号通路疾病及药物研发中的别构结合协同作用
Cristina Olivieri,Jian Wu,Susan S Taylor et al.
Cristina Olivieri et al.
Protein kinases catalyze the transfer of phosphate groups from ATP to specific substrates, initiating, modulating, or terminating signaling cascades. Generally, the response of these enzymes to stimuli is characterized by ultrasensitive rat...
Old and new tactics of CRISPR-centric competition between bacteria and bacteriophages [0.03%]
细菌和噬菌体之间以CRISPR为中心的竞赛中的老策略与新策略
Iktae Kim,Jeong-Yong Suh
Iktae Kim
The CRISPR-Cas system provides adaptive immunity for prokaryotes against mobile genetic elements (MGEs) such as bacteriophages and plasmids. As a countermeasure, MGEs have evolved various anti-CRISPR (Acr) mechanisms that neutralize the CRI...
Membrane protein reconstitution : New possibilities for structural biology, biophysical methods, and antibody/drug discovery [0.03%]
膜蛋白重组在结构生物学、生物物理方法及抗体/药物发现中的新机遇
Liguo Wang,Robert S Prosser
Liguo Wang
Luca R Genz,Sanjana Nair,Aaron Sweeney et al.
Luca R Genz et al.
Protein-nucleic acid interactions are vital to gene regulation and disease, yet have long been considered "undruggable." Recent advances are reshaping this paradigm, enabling therapeutic targeting of DNA- and RNA-binding proteins. In this r...
Dictionary based approaches for studying intrinsic DNA shape in transcription factor recognition [0.03%]
基于词典的内在DNA形状在转录因子识别中的研究方法
Manisha Kalsan,Sadiya Mirza,Divyangana Bathla et al.
Manisha Kalsan et al.
Sequence-dependent intrinsic conformational dynamics confer specificity to transcriptional factor recognition of genomic DNA. Their genome-scale investigation using all-atom simulations is challenging, and alternative approaches by coarse-g...
Jeremy A Owen,Leonid A Mirny
Jeremy A Owen
Epigenetic memory-the stable inheritance of a cellular state over cell generations-has long been associated with chromatin modifications. But individual modifications are very dynamic. How can they carry information across cell generations?...
Recent advances in DNA-encoded libraries: From covalent targeting to protein profiling [0.03%]
用于目标筛选的DNA编码化合物库的最新研究进展：从共价靶向到蛋白谱分析
Rui Jin,Xiaojie Lu
Rui Jin
DNA-encoded library (DEL) technology has enabled efficient discovery of both non-covalent and covalent inhibitors, with covalent binders typically identified via covalent DELs (CoDELs) containing diverse electrophilic warheads. Recent devel...
Editorial overview: Macromolecular assemblies: Technology innovations driving biological understanding [0.03%]
述评：大分子复合物：技术革新驱动生物学研究发展
Christopher P Hill,Elena V Orlova
Christopher P Hill
Understanding how structure shapes the architecture of homologous recombination [0.03%]
理解结构如何塑造同源重组的架构
Francesco Rinaldi,Stefania Girotto
Francesco Rinaldi
Cells have evolved multiple pathways to preserve genome integrity, with homologous recombination (HR) playing a central role in the accurate repair of DNA-double strand breaks (DSBs) by using homologous templates. Several proteins are invol...