Jiake Xu,Hua Fei Wu,Estabelle S M Ang et al.
Jiake Xu et al.
Osteoclasts are responsible for bone resorption and play a pivotal role in the pathogenesis of osteolytic disorders. NF-kappaB is a set of nuclear factors that bind to consensus DNA sequences called kappaB sites, and is essential for osteoc...
S Georges,C Ruiz Velasco,V Trichet et al.
S Georges et al.
Bone remodelling is regulated by osteogenic cells which act individually through cellular and molecular interaction. These interactions can be established either through a cell-cell contact, involving molecules of the integrin family, or by...
James E McLaren,Dipak P Ramji
James E McLaren
Atherosclerosis is a chronic inflammatory disease that is characterized by the development of fibrotic plaques in the arterial wall. The disease exhibits a complex aetiology and its progression is influenced by a number of environmental and...
The dual role of IL-6-type cytokines on bone remodeling and bone tumors [0.03%]
白细胞介素-6型细胞因子在骨重建和骨肿瘤中的双重作用
Frédéric Blanchard,Laurence Duplomb,Marc Baud&#x;huin et al.
Frédéric Blanchard et al.
Many factors such as vitamins, hormones and cytokines, control bone metabolism and remodeling. Cytokines of the interleukin-6 family, by acting on bone cells (i.e. osteoblasts and osteoclasts), have an important role in the bone tissue but ...
Cytokine and cytokine receptor gene polymorphisms and their functionality [0.03%]
细胞因子和细胞因子受体基因多态性及其功能效应
Andrew J P Smith,Steve E Humphries
Andrew J P Smith
Cytokines, signaling proteins produced by a variety of cell types, are essential for the development and functioning of both innate and adaptive immune response. Cytokine gene expression is tightly regulated, and aberrant expression from en...
p204, a p200 family protein, as a multifunctional regulator of cell proliferation and differentiation [0.03%]
P204：一种调控细胞增殖和分化的P200家族多效性调节蛋白
Yi Luan,Peter Lengyel,Chuan-Ju Liu
Yi Luan
The interferon-inducible p200 family comprises a group of homologous mouse and human proteins. Most of these have an N-terminal DAPIN domain and one or two partially conserved, 200 amino acid long C-terminal domains (designated as 200X doma...
Interferon and cytokine responses to Crimean Congo hemorrhagic fever virus; an emerging and neglected viral zonoosis [0.03%]
克里米亚-刚果出血热病毒的干扰素和细胞因子反应；一种新兴且被忽视的病毒性虫媒病
Friedemann Weber,Ali Mirazimi
Friedemann Weber
Crimean Congo hemorrhagic fever virus (CCHFV) causes an acute disease with the potential of a fatal outcome. The virus is prevalent in about 30 countries. Clinical symptoms of infection commonly include fever, myalgia, and hemorrhages. Leve...
Kathryn X Wang,David T Denhardt
Kathryn X Wang
Recent research has led to a better but as yet incomplete understanding of the complex roles osteopontin plays in mammalian physiology. A soluble protein found in all body fluids, it stimulates signal transduction pathways (via integrins an...
Julie Piessevaux,Delphine Lavens,Frank Peelman et al.
Julie Piessevaux et al.
The suppressors of cytokine signalling (SOCS) box is a structural domain found at the C-terminus of over 70 human proteins. It is usually coupled to a protein interaction module such as an SH2 domain in case of SOCS proteins, a family of mo...
Pivotal role for TGF-beta in infectious heart disease: The case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy [0.03%]
转化生长因子-β在感染性心脏病中的核心作用及克鲁氏锥虫感染与查加斯病心肌炎的关系
Tania C Araújo-Jorge,Mariana C Waghabi,Maria de Nazaré C Soeiro et al.
Tania C Araújo-Jorge et al.
This paper summarizes recent data from the literature suggesting that transforming growth factor-beta (TGF-beta) participates at least in four different processes influencing development of myocardiopathy in Chagas disease, a major parasiti...