Leukemia inhibitory factor and interleukin-11: critical regulators in the establishment of pregnancy [0.03%]
妊娠建立的关键调节因子转化生长因子和白血病抑制因子
Premila Paiva,Ellen Menkhorst,Lois Salamonsen et al.
Premila Paiva et al.
Blastocyst implantation into a receptive endometrium is critical to the establishment of pregnancy and is tightly regulated by factors within the blastocyst-endometrial micro-environment. Leukemia inhibitory factor (LIF) and interleukin-11 ...
Linda Vona-Davis,David P Rose
Linda Vona-Davis
The prevalence of overweight and obesity is rapidly increasing world wide. Numerous epidemiological studies have shown that obesity is a risk factor for postmenopausal breast cancer and relapse. However, the biological factors that drive th...
Implications of cytokine gene polymorphisms on the orchestration of the immune response: lessons learned from oral diseases [0.03%]
细胞因子基因多态性对免疫反应调控的影响——口腔疾病的研究启示
Walderez O Dutra,Paula R Moreira,Paulo Eduardo A Souza et al.
Walderez O Dutra et al.
Over the past 10 years, a plethora of information concerning the influence of gene polymorphisms on cytokine expression has been made available in the literature. Significant contribution to this field has come from studies of oral diseases...
Laurent David,Jean-Jacques Feige,Sabine Bailly
Laurent David
Bone morphogenetic proteins (BMPs) are multifunctional growth factors belonging to the transforming growth factor beta (TGFbeta) superfamily. Recent observations clearly emphasize the emerging role of BMPs in angiogenesis: (i) two genetic v...
Wendy V Ingman,Sarah A Robertson
Wendy V Ingman
Transforming growth factor beta 1 (TGFB1) is implicated as a key regulator of the development and cyclic remodelling characteristic of reproductive tissues. The physiological significance of TGFB1 in reproductive biology and fertility has b...
Cell responses to bone morphogenetic proteins and peptides derived from them: biomedical applications and limitations [0.03%]
骨形态发生蛋白及其衍生肽的细胞反应：生物医学应用和局限性
H Senta,H Park,E Bergeron et al.
H Senta et al.
The bone morphogenetic proteins (BMPs) are cytokines of the transforming growth factor beta family. Some BMPs such as BMP-2 and BMP-7 play a major role in the development of the skeleton and the maintenance of homeostasis during bone remode...
Cytokine regulation during the formation of the fetal-maternal interface: focus on cell-cell adhesion and remodelling of the extra-cellular matrix [0.03%]
细胞因子在胎盘屏障形成过程中的调节作用：以细胞粘附和细胞外基质重塑为例
Miranda McEwan,Roger J Lins,Sheryl K Munro et al.
Miranda McEwan et al.
The establishment of human pregnancy requires the orchestration of substantial cell differentiation and tissue remodelling processes in the context of a complex dialogue between the receptive endometrium and the implanting blastocyst, and i...
Alberto Ortiz,Ana Belén Sanz,Begoña Muñoz García et al.
Alberto Ortiz et al.
TWEAK is a cytokine of the TNF superfamily that activates the Fn14 receptor. TWEAK may regulate cell proliferation, cell death, cell differentiation, angiogenesis and inflammation. The expression of TWEAK and Fn14 is increased during vascul...
Growth factor based therapies and intestinal disease: is glucagon-like peptide-2 the new way forward? [0.03%]
基于生长因子的治疗和肠病：胰高血糖素样肽-2是新的发展方向吗？
Roger Yazbeck,Gordon S Howarth,Catherine A Abbott
Roger Yazbeck
Inflammatory bowel disease (IBD) is a chronic, debilitating disease associated with severe damage to the intestinal mucosa. Glucagon-like peptide-2 (GLP-2) is a potent and specific gastrointestinal growth factor that is demonstrating therap...