Bone morphogenetic proteins, cementogenesis, myoblastic stem cells and the induction of periodontal tissue regeneration [0.03%]
骨形态发生蛋白、造骨作用、肌样干细胞及牙周组织再生的诱导
Ugo Ripamonti,Jean-Claude Petit
Ugo Ripamonti
'Bone: Formation by autoinduction', initiates by invocation of soluble molecular signals which, when combined to insoluble signals or substrata trigger the ripple-like cascade of bone differentiation by induction. The osteogenic proteins of...
Elena Corradini,Jodie L Babitt,Herbert Y Lin
Elena Corradini
The BMP signaling pathway controls a number of cell processes during development and in adult tissues. At the cellular level, ligands of the BMP family act by binding a hetero-tetrameric signaling complex, composed of two type I and two typ...
The FOP metamorphogene encodes a novel type I receptor that dysregulates BMP signaling [0.03%]
FOP变形基因编码一种新型I型受体从而扰乱BMP信号转导路径
Frederick S Kaplan,Robert J Pignolo,Eileen M Shore
Frederick S Kaplan
The ability of mature organisms to stabilize phenotypes has enormous selective advantage across all phyla, but the mechanisms have been largely unexplored. Individuals with fibrodysplasia ossificans progressiva (FOP), a rare genetic disorde...
Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism [0.03%]
骨形态发生蛋白在脂肪细胞生成和能量代谢中的新作用
Tim J Schulz,Yu-Hua Tseng
Tim J Schulz
Bone morphogenetic proteins (BMPs) regulate many processes in embryonic development as well as in the maintenance of normal tissue function later in adult life. However, the role of this family of proteins in formation of adipose tissue has...
Human dental pulp stem cells with highly angiogenic and neurogenic potential for possible use in pulp regeneration [0.03%]
具有高血管生成和神经发生潜能的人牙髓干细胞用于可能的牙髓再生
Misako Nakashima,Koichiro Iohara,Masahiko Sugiyama
Misako Nakashima
Dental caries is a common public health problem, causing early loss of dental pulp and resultant tooth loss. Dental pulp has important functions to sustain teeth providing nutrient and oxygen supply, innervation, reactionary/reparative dent...
Bidirectional extracellular matrix signaling during tissue morphogenesis [0.03%]
组织形态发生过程中的双向细胞外基质信号转导
Nikolce Gjorevski,Celeste M Nelson
Nikolce Gjorevski
Normal tissue development and function are regulated by the interplay between cells and their surrounding extracellular matrix (ECM). The ECM provides biochemical and mechanical contextual information that is conveyed from the cell membrane...
Integration of BMP and Wnt signaling via vertebrate Smad1/5/8 and Drosophila Mad [0.03%]
脊椎动物Smad1/5/8和果蝇Mad整合BMP和Wnt信号通路
Edward Eivers,Hadrien Demagny,E M De Robertis
Edward Eivers
BMPs pattern the dorsal-ventral axis of vertebrate embryos. Smad1/5/8 transduces the BMP signal, and receives phosphorylation inputs from both MAPK and GSK3. Phosphorylation of Smad1 by MAPK and GSK3 result in its polyubiquitination and tra...
T William Axelrad,Thomas A Einhorn
T William Axelrad
Bone healing is a predictable process that has a high rate of success. For some patients, and in certain clinical settings, this process can be delayed or completely inhibited. This leads to significant morbidity and may also result in time...
Vicki Rosen
Vicki Rosen
BMPs are best known for their actions as bone formation signals. Recent studies using transgenic mice in which individual osteogenic BMPs have been removed from the limb skeleton have identified BMP2 as a fundamental component of the inhere...
Control of microRNA biogenesis by TGFbeta signaling pathway-A novel role of Smads in the nucleus [0.03%]
TGF-β信号通路对微小核糖核酸生物生成的调控-Smad蛋白在细胞核内的新作用
Akiko Hata,Brandi N Davis
Akiko Hata
microRNAs (miRNAs) are small, non-coding RNAs that modulate diverse biological functions through the repression of target genes. miRNA profiling studies have indicated that the levels of miRNAs are altered during normal development and path...