T William Axelrad,Thomas A Einhorn
T William Axelrad
Bone healing is a predictable process that has a high rate of success. For some patients, and in certain clinical settings, this process can be delayed or completely inhibited. This leads to significant morbidity and may also result in time...
Vicki Rosen
Vicki Rosen
BMPs are best known for their actions as bone formation signals. Recent studies using transgenic mice in which individual osteogenic BMPs have been removed from the limb skeleton have identified BMP2 as a fundamental component of the inhere...
Control of microRNA biogenesis by TGFbeta signaling pathway-A novel role of Smads in the nucleus [0.03%]
TGF-β信号通路对微小核糖核酸生物生成的调控-Smad蛋白在细胞核内的新作用
Akiko Hata,Brandi N Davis
Akiko Hata
microRNAs (miRNAs) are small, non-coding RNAs that modulate diverse biological functions through the repression of target genes. miRNA profiling studies have indicated that the levels of miRNAs are altered during normal development and path...
Transforming Growth Factor type beta and Smad family signaling in stem cell function [0.03%]
转化生长因子β和Smad族信号在干细胞功能中的作用
Eve Seuntjens,Lieve Umans,An Zwijsen et al.
Eve Seuntjens et al.
Ligands of the Transforming Growth Factor type beta (TGFbeta) family exert multiple and sometimes opposite effects on most cell types in vivo depending on cellular context, which mainly includes the stage of the target cell, the local envir...
Inge Seim,Adrian C Herington,Lisa K Chopin
Inge Seim
Ghrelin is a multi-functional peptide hormone that affects a range of processes, including growth hormone and insulin release, appetite regulation, reproduction, and cancer cell proliferation. The main focus of this review is to advance the...
12th international TNF conference: the good, the bad and the scientists [0.03%]
第十届国际肿瘤坏死因子大会：善恶难辨的科学家们
David Wallach,Andrew Kovalenko
David Wallach
Members of the TNF superfamily control numerous aspects of immune defense as well as various processes of homeostasis and embryonic development. Recent advances in our knowledge of both the beneficial and the deleterious activities of these...
Bioimmunoadjuvants for the treatment of neoplastic and infectious disease: Coley's legacy revisited [0.03%]
科利毒素的现代诠释：肿瘤和感染性疾病的生物免疫佐剂治疗
William K Decker,Amar Safdar
William K Decker
In the nineteenth century, William B. Coley induced durable remission of inoperable metastatic sarcoma by repeatedly injecting live streptococcus bacilli and, subsequently, heat-killed bacterial extracts into the primary tumor. While Coley'...
H G Laverty,L M Wakefield,N L Occleston et al.
H G Laverty et al.
With the development of growth factors and growth factor modulators as therapeutics for a range of disorders, it is prudent to consider whether modulating the growth factor profile in a tissue can influence tumour initiation or progression....
Cytokines and junction restructuring events during spermatogenesis in the testis: an emerging concept of regulation [0.03%]
生精过程中睾丸细胞因子和连接重塑事件：一种新的调节概念
Michelle W M Li,Dolores D Mruk,Will M Lee et al.
Michelle W M Li et al.
During spermatogenesis in mammalian testes, junction restructuring takes place at the Sertoli-Sertoli and Sertoli-germ cell interface, which is coupled with germ cell development, such as cell cycle progression, and translocation of the ger...
The role of differential expression of human interferon--a genes in antiviral immunity [0.03%]
人IFN-α基因差异表达在抗病毒免疫中的作用研究
Pierre Génin,Alexandra Vaccaro,Ahmet Civas
Pierre Génin
Immune recognition of virus-associated molecules by Toll-like receptors (TLRs) and/or RIG-I-like receptors (RLRs) triggers intracellular signaling cascades that converge on the activation of interferon regulatory factors - particularly IRF3...