Frances Balkwill,Alberto Mantovani
Frances Balkwill
Juan Rodriguez-Vita,Toby Lawrence
Juan Rodriguez-Vita
Inflammation has long been thought to contribute to the development of cancer; however there is also clear evidence that the immune system can recognize and eliminate cancer cells. Current research suggests that cancer-associated inflammati...
Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer [0.03%]
危险的关系：STAT3与NF-κB在癌症中的合作与相互影响
Sergei I Grivennikov,Michael Karin
Sergei I Grivennikov
Transcriptional factors of the NF-kappaB family and STAT3 are ubiquitously expressed and control numerous physiological processes including development, differentiation, immunity, metabolism and cancer. Both NF-kappaB and STAT3 are rapidly ...
Brian Bierie,Harold L Moses
Brian Bierie
The transforming growth factor beta (TGF-beta) has been studied with regard to the regulation of cell behavior for over three decades. A large body of research has been devoted to the regulation of epithelial cell and derivative carcinoma c...
Matricellular proteins and inflammatory cells: a task force to promote or defeat cancer? [0.03%]
基质细胞因子蛋白和炎症细胞：促进还是抑制癌症？
Andrea Sabina Llera,Maria Romina Girotti,Lorena Gabriela Benedetti et al.
Andrea Sabina Llera et al.
In the last years it became clear that the tumor microenvironment plays a major role in neoplastic growth. Proteins secreted either by the malignant cells or by the tumor-associated stromal cells act as extracellular signal transductors, or...
Lymphocytes in cancer development: polarization towards pro-tumor immunity [0.03%]
淋巴细胞在癌症发生发展过程中向促肿瘤免疫极化
Brian Ruffell,David G DeNardo,Nesrine I Affara et al.
Brian Ruffell et al.
The classic view that the role of immune cells in cancer is primarily one of tumor rejection has been supplanted by a more complex view of leukocytes having both pro- and anti-tumor properties. This shift is due to the now well recognized c...
CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis [0.03%]
趋化因子C亚家族成员CCL2促进前列腺癌的发生发展及转移
Jian Zhang,Lalit Patel,Kenneth J Pienta
Jian Zhang
CCL2 is a chemokine known to recruit monocytes and macrophages to sites of inflammation. A growing body of research suggests CCL2 is progressively overexpressed in tumor beds and may play a role in the clinical progression of solid tumors. ...
Napoleone Ferrara
Napoleone Ferrara
FDA approval of several inhibitors of the VEGF pathway has enabled significant advances in the therapy of cancer and neovascular age-related macular degeneration. However, similar to other therapies, inherent/acquired resistance to anti-ang...
Alberto Mantovani,Benedetta Savino,Massimo Locati et al.
Alberto Mantovani et al.
Chemokines are a key component of cancer-related inflammation. Chemokines and chemokine receptors are downstream of genetic events that cause neoplastic transformation and are components of chronic inflammatory conditions, which predispose ...
Joachim Nickel,Walter Sebald,Jay C Groppe et al.
Joachim Nickel et al.
The TGF-beta superfamily exhibits a feature making it distinct from many other growth factor families in that the inadequate number of ligands and receptors premises a high degree of promiscuity in ligand-receptor interaction. This highligh...