Napoleone Ferrara
Napoleone Ferrara
FDA approval of several inhibitors of the VEGF pathway has enabled significant advances in the therapy of cancer and neovascular age-related macular degeneration. However, similar to other therapies, inherent/acquired resistance to anti-ang...
Alberto Mantovani,Benedetta Savino,Massimo Locati et al.
Alberto Mantovani et al.
Chemokines are a key component of cancer-related inflammation. Chemokines and chemokine receptors are downstream of genetic events that cause neoplastic transformation and are components of chronic inflammatory conditions, which predispose ...
Joachim Nickel,Walter Sebald,Jay C Groppe et al.
Joachim Nickel et al.
The TGF-beta superfamily exhibits a feature making it distinct from many other growth factor families in that the inadequate number of ligands and receptors premises a high degree of promiscuity in ligand-receptor interaction. This highligh...
Perivascular multi-lineage progenitor cells in human organs: regenerative units, cytokine sources or both? [0.03%]
器官中的血管周围多谱系祖细胞：再生单元、细胞因子来源或两者兼有？
Chien-Wen Chen,Elisa Montelatici,Mihaela Crisan et al.
Chien-Wen Chen et al.
Multi-lineage progenitors, e.g. mesenchymal stem cells, persist in adult developed organs, making a windfall for the cell therapist but an enigma for stem cell biologists. Recent results from our own and other laboratories show that the anc...
Lindolfo da Silva Meirelles,Aparecida Maria Fontes,Dimas Tadeu Covas et al.
Lindolfo da Silva Meirelles et al.
Mesenchymal stem cells (MSCs) have been described as being able to give rise to several quite different mesenchymal cell phenotypes. However, the ability to differentiate is not the only characteristic that makes these cells attractive for ...
Buer Song,Kristine D Estrada,Karen M Lyons
Buer Song
Smad proteins are intracellular molecules that mediate the canonical signaling cascade of TGFbeta superfamily growth factors. The TGFbeta superfamily comprises two groups of growth factors, BMPs and TGFbetas. Both groups can be further divi...
Charles C Hong,Paul B Yu
Charles C Hong
Bone morphogenetic proteins (BMPs) provide critical signals for determining cell fate, specifying gastrulation, embryonic patterning, organogenesis, and the remodeling of diverse tissues. Recent work has suggested that in addition to coordi...
Design of second generation therapeutic recombinant bone morphogenetic proteins [0.03%]
第二代治疗性重组骨形态蛋白药物的设计
Moulay Hicham Alaoui-Ismaili,Dean Falb
Moulay Hicham Alaoui-Ismaili
Bone morphogenetic proteins (BMPs) are growth factors belonging to the TGF beta super family. To date, more than twenty human BMPs have been identified. Of these, BMP-2 and BMP-7 (also known as osteogenic protein 1 or OP-1) are the only BMP...
Steven Pregizer,Douglas P Mortlock
Steven Pregizer
Much evidence suggests that "developmental regulator" genes, like those encoding transcription factors and signaling molecules, are typically controlled by many modular, tissue-specific cis-regulatory elements that function during embryogen...
Rik J U Lories,Frank P Luyten
Rik J U Lories
Chronic joint diseases have a major impact on society as patients suffer from pain and disability. The spectrum of arthritic disorders is wide including autoimmune and autoinflammatory diseases such as rheumatoid arthritis, ankylosing spond...