Oncolytic viral purging of leukemic hematopoietic stem and progenitor cells with Myxoma virus [0.03%]
瘤苗病毒清除白血病造血干细胞和祖细胞的研究——以痘苗病毒为例
Masmudur M Rahman,Gerard J Madlambayan,Christopher R Cogle et al.
Masmudur M Rahman et al.
High-dose chemotherapy and radiation followed by autologous blood and marrow transplantation (ABMT) has been used for the treatment of certain cancers that are refractory to standard therapeutic regimes. However, a major challenge with ABMT...
A call to arms: using RNAi screening to improve oncolytic viral therapy [0.03%]
迫切呼吁：利用RNA干扰筛选技术改善溶瘤病毒疗法
D J Mahoney,D F Stojdl
D J Mahoney
Replicating virus-based therapeutics for cancer, or oncolytic virus therapy (OVT), is rapidly emerging as a promising treatment modality for a wide range of cancers. In pre-clinical studies, oncolytic viruses have produced remarkable result...
Molecular mechanisms of perineural invasion, a forgotten pathway of dissemination and metastasis [0.03%]
外周神经侵犯的分子机制：一条被遗忘的转移通路
Federica Marchesi,Lorenzo Piemonti,Alberto Mantovani et al.
Federica Marchesi et al.
Invasion and metastasis are key components of cancer progression. Inflammatory mediators, including cytokines and chemokines, can facilitate tumor dissemination. A distinct and largely forgotten path is perineural invasion (PNI), defined as...
Frances Balkwill,Alberto Mantovani
Frances Balkwill
Juan Rodriguez-Vita,Toby Lawrence
Juan Rodriguez-Vita
Inflammation has long been thought to contribute to the development of cancer; however there is also clear evidence that the immune system can recognize and eliminate cancer cells. Current research suggests that cancer-associated inflammati...
Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer [0.03%]
危险的关系：STAT3与NF-κB在癌症中的合作与相互影响
Sergei I Grivennikov,Michael Karin
Sergei I Grivennikov
Transcriptional factors of the NF-kappaB family and STAT3 are ubiquitously expressed and control numerous physiological processes including development, differentiation, immunity, metabolism and cancer. Both NF-kappaB and STAT3 are rapidly ...
Brian Bierie,Harold L Moses
Brian Bierie
The transforming growth factor beta (TGF-beta) has been studied with regard to the regulation of cell behavior for over three decades. A large body of research has been devoted to the regulation of epithelial cell and derivative carcinoma c...
Matricellular proteins and inflammatory cells: a task force to promote or defeat cancer? [0.03%]
基质细胞因子蛋白和炎症细胞：促进还是抑制癌症？
Andrea Sabina Llera,Maria Romina Girotti,Lorena Gabriela Benedetti et al.
Andrea Sabina Llera et al.
In the last years it became clear that the tumor microenvironment plays a major role in neoplastic growth. Proteins secreted either by the malignant cells or by the tumor-associated stromal cells act as extracellular signal transductors, or...
Lymphocytes in cancer development: polarization towards pro-tumor immunity [0.03%]
淋巴细胞在癌症发生发展过程中向促肿瘤免疫极化
Brian Ruffell,David G DeNardo,Nesrine I Affara et al.
Brian Ruffell et al.
The classic view that the role of immune cells in cancer is primarily one of tumor rejection has been supplanted by a more complex view of leukocytes having both pro- and anti-tumor properties. This shift is due to the now well recognized c...
CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis [0.03%]
趋化因子C亚家族成员CCL2促进前列腺癌的发生发展及转移
Jian Zhang,Lalit Patel,Kenneth J Pienta
Jian Zhang
CCL2 is a chemokine known to recruit monocytes and macrophages to sites of inflammation. A growing body of research suggests CCL2 is progressively overexpressed in tumor beds and may play a role in the clinical progression of solid tumors. ...