Novel insights into neuroinflammatory mechanisms in traumatic brain injury: Focus on pattern recognition receptors as therapeutic targets [0.03%]
创伤性脑损伤中神经炎症机制的新见解——模式识别受体作为治疗靶点:focus
Harapriya Baral,Ravinder K Kaundal
Harapriya Baral
Traumatic brain injury (TBI) is a major global health concern and a leading cause of morbidity and mortality. Neuroinflammation is a pivotal driver of both the acute and chronic phases of TBI, with pattern recognition receptors (PRRs) playi...
John Hiscott
John Hiscott
Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy [0.03%]
肿瘤微环境中IL-6/JAK/STAT3信号的见解及其对癌症治疗的意义
Win Lwin Thuya,Yang Cao,Paul Chi-Lui Ho et al.
Win Lwin Thuya et al.
The IL-6/JAK/STAT3 signaling pathway is a key regulator of tumor progression, immune evasion, and therapy resistance in various cancers. Frequently dysregulated in malignancies, this pathway drives cancer cell growth, survival, angiogenesis...
The immunopathogenesis of a cytokine storm: The key mechanisms underlying severe COVID-19 [0.03%]
细胞因子风暴的免疫病理ogenesis：严重COVID-19的关键机制
Luka Hiti,Tijana Markovič,Mitja Lainscak et al.
Luka Hiti et al.
A cytokine storm is marked by excessive pro-inflammatory cytokine release, and has emerged as a key factor in severe COVID-19 cases - making it a critical therapeutic target. However, its pathophysiology was poorly understood, which hindere...
Molecular regulation of mitophagy signaling in tumor microenvironment and its targeting for cancer therapy [0.03%]
肿瘤微环境中线粒体自噬信号的分子调控及其在癌症治疗中的靶向作用研究
Bishnu Prasad Behera,Soumya Ranjan Mishra,Srimanta Patra et al.
Bishnu Prasad Behera et al.
Aberrations emerging in mitochondrial homeostasis are restrained by mitophagy to control mitochondrial integrity, bioenergetics signaling, metabolism, oxidative stress, and apoptosis. The mitophagy-accompanied mitochondrial processes that o...
Interleukin-17: A pleiotropic cytokine implicated in inflammatory, infectious, and malignant disorders [0.03%]
白介素-17：一种与炎症、感染和肿瘤相关的多功能细胞因子
Anushka Saran,Daisuke Nishizaki,Scott M Lippman et al.
Anushka Saran et al.
IL-17A, referred to as IL-17, is the founding member of a family of pro-inflammatory cytokines, including IL-17B, IL-17C, IL-17D, IL-17E (or IL-25), and IL-17F, which act via receptors IL-17RA to IL-17RE, and elicit potent cellular response...
Interleukin-6 (IL-6)-associated tumor microenvironment remodelling and cancer immunotherapy [0.03%]
与白细胞介素6（IL-6）相关的肿瘤微环境重塑和癌症免疫治疗
Songsong Wu,Zhumin Cao,Rongying Lu et al.
Songsong Wu et al.
Interleukin-6 (IL-6) is a pro-inflammatory cytokine playing a pivotal role during inflammation and immune responses. In the recent years, the function of IL-6 in the tumor microenvironment (TME) for affecting tumorigenesis and immunotherapy...
Mechanisms coupling the mTOR pathway to chronic obstructive pulmonary disease (COPD) pathogenesis [0.03%]
构成mTOR信号通路与慢性阻塞性肺病(COPD)发病机制之间联系的分子机制研究进展
Ankita Goyal,Vishal Chopra,Kranti Garg et al.
Ankita Goyal et al.
Chronic Obstructive Pulmonary Disease (COPD) is a poorly reversible respiratory disorder distinguished by dyspnea, cough, expectoration and exacerbations due to abnormality of airways or emphysema. In this review, we consider the therapeuti...
Nuclear translocation of RON receptor tyrosine kinase. New mechanistic and functional insights [0.03%]
RON酪氨酸激酶受体的核转位 新的机制和功能见解
Yi-Lin Chen,Chien-An Chu,Jiu-Yao Wang et al.
Yi-Lin Chen et al.
Receptor tyrosine kinases (RTKs) are membrane sensors that monitor alterations in the extracellular milieu and translate this information into appropriate cellular responses. Epidermal growth factor receptor (EGFR) is the most well-known mo...
Granulocyte macrophage colony stimulating factor in virus-host interactions and its implication for immunotherapy [0.03%]
病毒-宿主相互作用中的粒细胞-巨噬细胞集落刺激因子及其在免疫治疗中的应用
Nasry Zane Bouzeineddine,Alecco Philippi,Katrina Gee et al.
Nasry Zane Bouzeineddine et al.
Viruses have evolved to strategically exploit cellular signaling pathways to evade host immune defenses. GM-CSF signaling plays a pivotal role in regulating inflammation, activating myeloid cells, and enhancing the immune response to infect...