Exploring AI tools and multi-omics for precision medicine in lung cancer therapy [0.03%]
探索AI工具和多组学在肺癌治疗精确诊疗中的应用
Arvindra Sahu,Priyanshu Nema,Devraj Rajak et al.
Arvindra Sahu et al.
Lung cancer is a leading cause of cancer-related mortality worldwide, characterized by the uncontrolled growth and spread of abnormal cells. Despite constant progress in diagnosis and treatment of lung cancer remains highly challenging. Pre...
Targeting macrophage-directed pathological processes in pancreatic ductal adenocarcinoma: Mechanisms and targeted therapies [0.03%]
胰腺导管腺癌中针对巨噬细胞相关病理过程的机制及靶向治疗
Zhou Chen,Defeng Guan,Yan Wang et al.
Zhou Chen et al.
Macrophages support the malignant transformation of pancreatic ductal adenocarcinoma cells by secreting cytokines and enzymes, which enhance tumor invasiveness and metastatic potential. In addition to promoting tumor growth, macrophages con...
Metabolic Regulation of cGAS-STING Signaling in the Tumor Microenvironment: Dual Immune Roles and Therapeutic Implications [0.03%]
肿瘤微环境中cGAS-STING信号的代谢调节：双重免疫作用和治疗意义
Yong Wu,Wen-Min Lu,Qian-Ru Cui et al.
Yong Wu et al.
The cGAS-STING pathway, a cytosolic DNA-sensing mechanism, plays a context-dependent pivotal role in tumor immunity and tumor microenvironment (TME) remodeling. Acute activation of this pathway promotes type I interferon (IFN-I) and pro-inf...
The central role of CXCL10-CXCR3 signaling in neuroinflammation and neuropathology [0.03%]
CXCL10-CXCR3信号在神经炎症和神经病理中的核心作用
Alexandro A Bufi,Julia Di Stefano,Andrea Papait et al.
Alexandro A Bufi et al.
The role of neuroinflammation is becoming increasingly prominent as our understanding of the mechanisms underlying central nervous system disorders advances. What makes this phenomenon particularly intriguing from a clinical perspective is ...
Nuclear receptors in pulmonary hypertension: From pathophysiological mechanisms to clinical implications [0.03%]
核受体在肺动脉高压中的作用：从病理生理机制到临床意义
Tianxin Xiong,Yi Li,Hong Chen et al.
Tianxin Xiong et al.
Pulmonary hypertension is one of the most intractable cardiovascular diseases in the world today. The current pharmacological treatments can temporarily relieve symptoms, but the therapeutic effect is unsatisfactory in advanced pulmonary hy...
Exploring inflammatory and fibrotic mechanisms driving diabetic nephropathy progression [0.03%]
探索炎症和纤维化机制在糖尿病肾病进展中的作用
Zeeshan Ansari,Ayush Chaurasia,Neha et al.
Zeeshan Ansari et al.
Diabetic nephropathy (DN) remains a leading cause of end-stage renal disease, with inflammation and fibrosis serving as pivotal drivers of disease progression. Chronic hyperglycemia induces oxidative stress, activates immune pathways, and p...
Susanna G Ford,Patrick Caswell,David Brough et al.
Susanna G Ford et al.
Interleukin (IL)-1β is a pro-inflammatory cytokine largely produced by cells of the innate immune system in response to tissue damage or to the presence of pathogens. IL-1β-driven inflammation is an established contributor to many disease...
Dimitrios G Argyris,Dimitra P Anastasiadou,Panagiota S Filippou et al.
Dimitrios G Argyris et al.
The chemokine CXCL16, often termed "Swiss army knife chemokine," plays diverse roles in tumor biology through its dual existence as a transmembrane (mCXCL16) and a soluble (sCXCL16) form. Signaling exclusively through its receptor CXCR6, th...
Wen Luo,Qingfeng Shi,Mingming Han et al.
Wen Luo et al.
The carcinogenesis and drug resistance can be accelerated by TGF-β, primarily by enhancing epithelial-mesenchymal transition (EMT). This review examines the complex mechanisms by which TGF-β drives EMT across different tumors, highlightin...
Efferocytosis at the frontline of homeostasis: Shaping the bone microenvironment and therapeutic implications in related diseases [0.03%]
吞噬细胞在稳态前线：塑造骨微环境及在相关疾病治疗中的意义
Liyile Chen,Ken Kadoya,Tsutomu Endo et al.
Liyile Chen et al.
Bone is a dynamic tissue that constantly undergoes remodeling processes throughout life to maintain its structure and integrity. During this process, physiological bone turnover, which is shaped by apoptosis, occurs in cells in the bone mic...